Synaptic depression and neuronal loss in transiently acidic hippocampal slice cultures

Brain Research

Volumn 881, Issue 1, 2000, Pages 77-87

  Xiang, Zhong Min ^a   Bergold, Peter J ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Bicarbonate; Disorders of the nervous system; Hypothermia; Intracellular pH; Ischemia; Lactate; Slice culture

Indexed keywords

BICARBONATE; LACTIC ACID;

ACIDOSIS; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL DEATH; CELL LOSS; CELL PH; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HYPOTHERMIA; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ACIDOSIS; ANIMAL; BICARBONATES; BUFFERS; CELL COUNT; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; TISSUE CULTURE;

EID: 0034693421     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02795-5     Document Type: Article

References (46)

1. Spreading depression-like hypoxic depolarization in CA1 and fascia dentata of hippocampal slices: relationship to selective vulnerability
2. Spatial and temporal changes in tissue pH and ATP distribution in a new model of reversible focal forebrain ischemia in the rat
3. +/nigericin for calibrating BCECF. II. Intracellular pH dependence of the correction
4. The regulation and modulation of intracellular pH in the nervous system
5. Electrophysiological properties of rat CA1 pyramidal neurones in vitro modified by changes in extracellular bicarbonate
6. Stability of brain intracellular lactate and 31P-metabolitelevels at reduced intracellular pH during prolonged hypercapnia in rats
7. pH regulation and proton signalling by glial cells
8. Acidosis induces necrosis and apoptosis of cultured hippocampal neurons
9. Organotypic slice cultures: a technique has come of age
10. The effects of extracellular acidosis on neurons and glia in vitro
11. Ionic basis of GABAA receptor channel function in the nervous system
12. Neuroprotective effects of glutamate antagonists and extracellular acidity
13. Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis
14. Acidosis induced by hypercapnia exaggerates ischemic brain damage
15. Hydrogen ions kill brain at concentrations reached in ischemia
16. Intracellular pH in rat brain in vivo and in brain slices
17. 2 on excitatory transmission apparently caused by changes in intracellular pH in the rat hippocampal slice
18. Role of hyperglycaemia-related acidosis in ischaemic brain damage
19. 2 acidosis on neuronal function following glucose-oxygen deprivation in rat hippocampal slices
20. Effect of 5-min ischemia on regional pH and energy state of the gerbil brain: relation to selective vulnerability of the hippocampus
21. Acid-induced death in neurons and glia
22. Markers for neuronal degeneration in organotypic slice cultures
23. Effect of lactacidosis on cell volume and intracellular pH of astrocytes
24. Aging impairs regulation of intracellular pH in rat hippocampal slices
25. The influence of age of pH regulation in hippocampal slices before, during, and after anoxia
26. Intracellular pH
27. Lactate-supported synaptic function in the rat hippocampal slice preparation
28. Brain lactate, not glucose, fuels the recovery of synaptic function from hypoxia upon reoxygenation: an in vitro study
29. Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: further in vitro validation
30. 3-exchange
31. Transient acidosis induces delayed neurotoxicity in cultured hippocampal slices
32. Acidosis-related damage
33. Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury
34. Swelling and death of neuronal cells by lactic acid
35. Lactate mimics only some effects of D-glucose on epileptic depolarization and long-term synaptic failure
36. +
37. Mild acidosis delays hypoxic spreading depression and improves neuronal recovery in hippocampal slices
38. Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia
39. + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones
40. Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia
41. The effects of lactate and beta-hydroxybutyrate on the energy metabolism and neural activity of hippocampal slices from adult and immature rat
42. The effects of glucose, mannose, fructose and lactate on the preservation of neural activity in the hippocampal slices from the guinea pig
43. Lactate release from cultured astrocytes and neurons: a comparison
44. Brain lactic acidosis and synaptic function
45. Long-term maintenance of mature hippocampal slices in vitro
46. 2+ and glycolysis