Long PCR detection of the C4A null allele in B8-C4AQ0-C4B1-DR3

Journal of Immunological Methods

Volumn 244, Issue 1-2, 2000, Pages 41-47

  Grant, Struan F A ^a   Kristjánsdóttir, Helga ^b   Steinsson, Kristján ^b   Blöndal, Thorarinn ^a   Yuryev, Anton ^a   Stefansson, Kári ^a   Gulcher, Jeffrey R ^a  

^a DECODE GENETICS   (Iceland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

Complement; Lupus; PCR; Primer; Retrovirus; Rheumatoid arthritis

Indexed keywords

COMPLEMENT COMPONENT C4A; PROTEIN;

ALLELE; ALLOTYPE; ARTICLE; GENE DELETION; GENE SEQUENCE; GENOTYPE; HAPLOTYPE; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RETROVIRUS; RHEUMATOID ARTHRITIS; SOUTHERN BLOTTING; SYSTEMIC LUPUS ERYTHEMATOSUS;

ALLELES; AUTOIMMUNE DISEASES; COMPLEMENT 4A; COMPLEMENT 4B; ENDOGENOUS RETROVIRUSES; GENE DELETION; GENOTYPE; HAPLOTYPES; HLA-A1 ANTIGEN; HLA-B8 ANTIGEN; HLA-DR3 ANTIGEN; HUMAN; POLYMERASE CHAIN REACTION; STEROID 21-HYDROXYLASE;

HUMAN ENDOGENOUS RETROVIRUS; HUMAN ENDOGENOUS RETROVIRUS K; SCLERODERMA; UNIDENTIFIED RETROVIRUS;

EID: 0034693360     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(00)00251-9     Document Type: Article

References (34)

1. Genetic aspects of human lupus
2. HLA class III molecules and autoimmune rheumatic diseases
3. Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to non-expression
4. A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B
5. Deletion of complement C4 and steroid 21-hydroxylase genes in the HLA class III region
6. Effective amplification of long targets from cloned inserts and human genomic DNA
7. The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates
8. Splenic uptake of immune complexes in man is complement-dependent
9. Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease
10. Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern Chinese
11. Genetic and immunological mechanisms in the pathogenesis of systemic lupus erythematosus
12. Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility
13. Regulation of the B cell response to T-dependent antigens by classical pathway complement
14. Characterization of non-expressed C4 genes in a case of complete C4 deficiency: identification of a novel point mutation leading to a premature stop codon
15. Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus
16. Deletion of C4A genes in patients with systemic lupus erythematosus
17. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited
18. DR3 and non-DR3 associated complement component C4A deficiency in systemic lupus erythematosus
19. The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences
20. Statement on the nomenclature of human C4 allotypes
21. MHC evolution and development of a recognition system
22. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 h: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation
23. Reduction of error rates in the microlymphocytotoxicity test
24. Inherited deficiencies of complement in rheumatic diseases
25. Null alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematosus
26. A molecular basis for the two locus model of human complement component C4
27. Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex
28. C4 DNA RFLP reference typing report
29. Polymorphism of the human complement C4 and steroid 21-hydroxylase genes. Restriction fragment length polymorphisms revealing structural deletions, homoduplications, and size variants
30. Phenotyping of human complement component C4, a class-III HLA antigen
31. A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland
32. Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K
33. Major histocompatibility complex (MHC) class III genetics in two Amerindian tribes from southern Brazil: the Kaingang and the Guarani
34. Definitive RFLPs to distinguish between the human complement C4A/C4B isotypes and the major Rodgers/Chido determinants: application to the study of C4 null alleles