Polyglutamation of antifolates is not required for induction of extracellular release of adenosine or expression of their anti-inflammatory effects

Immunopharmacology

Volumn 48, Issue 2, 2000, Pages 137-144

  Urakawa, Kazumi ^a   Mihara, Masahiko ^a   Suzuki, Takashi ^a   Kawamura, Akinori ^a   Akamatsu, Ken Ichi ^a   Takeda, Yasuhisa ^a   Kamatani, Naoyuki ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Adenosine; Anti inflammatory effects; Antifolates; MX 68; Polyglutamation

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE; FOLIC ACID ANTAGONIST; METHOTREXATE; N [[4 [(2,4 DIAMINO 6 PTERIDINYL)METHYL] 3,4 DIHYDRO 2H 1,4 BENZOTHIAZIN 7 YL]CARBONYL]HOMOGLUTAMIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

2-AMINOADIPIC ACID; ADENOSINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATTLE; CELL LINE; EXTRACELLULAR SPACE; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; METHOTREXATE; MICE; MICE, INBRED BALB C; PTEROYLPOLYGLUTAMIC ACIDS;

EID: 0034691591     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(00)00197-1     Document Type: Article

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