15SN isotope effects in glutamine hydrolysis catalyzed by carbamyl phosphate synthetase: Evidence for a tetrahedral intermediate in the mechanism

Biochemistry

Volumn 39, Issue 24, 2000, Pages 7309-7315

  Rishavy, Mark A ^a   Cleland, W Wallace ^a   Lusty, Carol J ^b  

^a UNIVERSITY OF WISCONSIN   (United States)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE MAGNESIUM; AMMONIA; CARBAMATE KINASE; CARBONIC ACID; GLUTAMINE; NITROGEN 15; ADENOSINE TRIPHOSPHATE; BICARBONATE; CARBAMOYL PHOSPHATE SYNTHASE (GLUTAMINE HYDROLYSING); NITROGEN;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION;

ADENOSINE TRIPHOSPHATE; BICARBONATES; BINDING SITES; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); ESCHERICHIA COLI; GLUTAMINE; HYDROLYSIS; KINETICS; MUTATION; NITROGEN ISOTOPES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0034690811     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000435z     Document Type: Article

References (37)

1. Meister, A. (1989) Adv. Enzymol. Relat. Areas Mol. Biol. 62, 315-374.
2. Zalkin, H., and Smith, J. L. (1998) Adv. Enzymol. Relat. Areas Mol. Biol. A 72, 87-144.
3. Buchanan, J. M. (1913) Adv. Enzymol. Relat. Areas Mol. Biol. 39, 91-183.
4. Wellner, V. P., Anderson, P. M., and Meister, A. (1973) Biochemistry 12, 2061-2066.
5. Chaparian, M. G., and Evans, D. R. (1991) J. Biol. Chem. 266, 3387-3395.
6. Lusty, C. J., and Liao, M. (1993) Biochemistry 32, 1278-1284.
7. Roux, B., and Walsh, C. T. (1992) Biochemistry 31, 6904-6910.
8. Lusty, C. J. (1992) FEBS Lett. 314, 135-138.
9. Thoden, J. B., Miran, S. G., Philips, J. C., Howard, A. J., Raushel, F. M., and Holden, H. M. (1998) Biochemistry 37, 8825-8831.
10. Roux, B., and Walsh, C. T. (1993) Biochemistry 32, 3763-3768.
11. Miles, B. W., Banzon, J. A., and Raushel, F. M. (1998) Biochemistry 37, 16773-16779.
12. Amuro, N., Paluh, J. L., and Zalkin, H. (1985) J. Biol. Chem. 260, 14844-14849.
13. Mei, B., and Zalkin, H. (1989) J. Biol. Chem. 264, 16613-16619.
14. Miran, S. G., Chang, S. H., and Raushel, F. M. (1991) Biochemistry 30, 7901-7907.
15. Tesmer, J. J. G., Klem, T. J., Deras, M. L., Davisson, V. J., and Smith, J. L. (1996) Nat. Struct. Biol. 3, 74-86.
16. Thoden, J. B., Huang, X., Raushel, F. M., and Holden, H. M. (1999) Biochemistry 38, 16158-16166.
17. Cleland, W. W. (1995) Methods Enzymol. 249, 341-373.
18. O'Leary, M. H. (1980) Methods Enzymol. 64, 83-104.
19. Guillou, F., Liao, M., Garcia-Espana, A., and Lusty, C. J. (1992) Biochemistry 31, 1656-1664.
20. Andersen, P. M. (1977) Biochemistry 16, 587-592.
21. Rubino, S. D., Nyunoya, H., and Lusty, C. J. (1986) J. Biol. Chem. 261, 11320-11327.
22. Andersen, P. M., and Meister, A. (1966) Biochemistry 5, 3157-3163.
23. Witt, I. (1974) in Methods of Enzymatic Analysis (Bergmeyer, H. U., Ed.) Vol. 4, pp 1713-1715, Academic Press, New York. (2nd English edition, translated from the 3rd German edition.)
24. Northrop, D. B. (1977) in Isotope Effects on Enzyme-Catalyzed Reactions (Cleland, W. W., O'Leary, M. H., and Northrop D. B., Eds,) pp 122-148, University Park Press, Baltimore, MD.
25. Moore, S., and Stein, W. H. (1954) J. Biol. Chem. 211, 893-906.
26. Leach, S. J., and Parkhill, E. M. J. (1955) Proc. Int. Wool Text. Res. Conf. B 3, 92-10).
27. Bremner, J. M. (1965) in Methods of Soil Analysis, Part 2 (Black C. A., Ed.) pp 1256-1286, American Society of Agronomy, Inc., Madison, WI.
28. Weiss, P. M. (1991) in Enzyme Mechanism from Isotope Effects (Cook, P. F., Ed.) pp 304-305, CRC Press, Boca Raton, FL.
29. Allen, C. M., Jr., and Jones, M. E. (1964) Biochemistry 3, 1238-1247.
30. Khedouri, E., Anderson, P. M., and Meister, A. (1966) Biochemistry 5, 3552-3557.
31. O'Leary, M. H., Urberg, M., and Young, A. P. (1974) Biochemistry 13, 2077-2081.
32. Waldrop, G. L., Urbauer, J. L., and Cleland, W. W. (1992) J. Am. Chem. Soc. 114, 5941-5945.
33. Hartman, S. C. (1973) in The Enzymes of Glutamine Metabolism (Prusiner, S., and Stadtman, E. R., Eds.) pp 320-321, Academic Press, New York.
34. Pinkus, L. M., and Meister, A. (1972) J. Biol. Chem. 247, 6119-6127.
35. Anderson, P. M., and Carlson, J. D. (1975) Biochemistry 14, 3688-3694.
36. Mullins, L. S., Lusty, C. J., and Raushel, F. M. (1991) J. Biol. Chem. 266, 8236-8240.
37. Cleland, W. W. (1963) Biochim. Biophys. Acta 67, 104-137.