Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 6, 2000, Pages 581-584

  Altomare, C ^a   Summo, L ^a   Cellamare, S ^b   Varlamov, A V ^c   Voskressensky, L G ^c   Borisova, T N ^c   Carotti, A ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c PEOPLES FRIENDSHIP UNIVERSITY OF RUSSIA   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; PYRROLO[3,2 C]PYRIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

ADENOSINE DIPHOSPHATE; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LIPIDS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PYRIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TICLOPIDINE;

EID: 0034689584     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00052-4     Document Type: Article

References (23)

1. Majerus, W.; Broza, G. J.; Miletich, J. P.; Tollesfsen, D. M. In The Goodman Gilman's Pharmacological Basis of Therapeutics; Goodman, L. S.; Gilman, A. G.; Limbird, L. E., Eds.; McGraw-Hill: New York, 1996; pp 1341-1359.
2. Gardell S.J. Perspect. Drug Discov. and Des. 1:1993;521.
3. Newmann F.J., Gawaz M., Dickfelt T., Wehinger A., Walter H., Blasini R., Schomig A. Ann. Intern. Med. 29:1998;394.
4. Heptinstall S., May J.A., Glenn J.R., Sanderson H.M., Dickinson J.P., Wilcox R.G. Thromb. Haemostasis. 74:1995;1310.
5. Shrör K. Platelets. 4:1993;252.
6. Trofimov B.A., Mikhaleva A.I. Heterocycles. 37:1994;1193.
7. Menke J.B. Rec. Trav. Chim. Pays Bas. 44:1925;141.
8. Trofimov, B. A.; Vasiltsov, A. M.; Mikhaleva, A. I.; Kalabin, G. A.; Shcherbakov, V. V.; Nesterenko, R. N.; Polubentsev, E. A.; Praliev, K. D. Khim. Geterotsikl. Soedin. 1991, 1365.
9. Aliev A.E., Sinitsyna A.A., Borisova T.N., Stazharova I.A., Prostakov N.S., Varlamov A.V. Chem. Heterocycl. Compd. (Engl. Transl.). 29:1993;65.
10. Quintana R.P., Lasslo A., Dugdale M., Goodin L.L. Thrombosis Res. 22:1981;665.
11. Lawrence W.H., Howell R.D., Gollamudi R. J. Pharm. Sci. 83:1994;222.
12. Maclog P 3.0 program (BioByte Corp., Claremont, CA, USA).
13. Hansch, C.; Leo, A. Substituent Constants for Correlation Analysis in Chemistry and Biology; John Wiley & Sons: New York, 1979.
14. Leo A., Hansch C., Elkins D. Chem. Rev. 71:1971;525.
15. A LUNA 5μ C18 column (150×4.6 mm i.d.) (Phenomenex, Torrance, CA, USA) was used as the stationary phase. The mobile phases consisted of different volume fractions of methanol in 0.01 M phosphate buffer (pH 4.50). All the measurements were made at a constant temperature of 25±0.5 °C and flow-rate of 1.0 mL/min on a Waters HPLC Model 600 multisolvent delivery system (Waters Assoc., Milford, MA, USA).
16. Altomare C., Cellamare S., Carotti A., Ferappi M. Quant. Struct-Act. Relat. 12:1993;261.
17. Altomare C., Cellamare S., Carotti A., Ferappi M. Farmaco. 49:1994;393.
18. Minick D.J., Brent D.A., Frenz J. J. Chromatogr. (A). 461:1989;177.
19. Chen N., Zhang Y., Lu P. J. Chromatogr. (A). 633:1993;31.
20. Luco J.M., Yamin L.J., Ferretti H.F. J. Pharm. Sci. 84:1995;903.
21. Abraham M.H., Chadha H.S., Mitchell R.C. J. Pharm. Sci. 83:1994;1257.
22. Boyd M., Boyd P.D.W., Atwell G.J., Wilson W.R., Denny W.A. J. Chem. Soc. Perkin Trans. 2:1992;579.
23. Feng Z., Gollamudi R., Dillingham E.O., Bond S.E., Lyman B.A., Purcell W.P., Hill R.J., Korfmacher W.A. J. Med. Chem. 35:1992;2952.