Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product Spongistatin 1

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 6, 2000, Pages 541-545

  Uckun, Fatih M ^a   Mao, Chen ^a   Vassilev, Alexei O ^a   Huang, He ^a   Jan, Shyi Tai ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHER DERIVATIVE; PYRAN DERIVATIVE; SPIROKETAL PYRAN; SPONGISTATIN 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BRAIN; BREAST CANCER; CANCER CELL; CATTLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; NONHUMAN; PHARMACOPHORE;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ETHERS, CYCLIC; HUMANS; LACTONES; MACROLIDES; MITOSIS; MODELS, MOLECULAR; NEPHELOMETRY AND TURBIDIMETRY; PORIFERA; PYRANS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

BOS TAURUS;

EID: 0034689178     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00044-5     Document Type: Article

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