A possible divergent role for the oestrogen receptor alpha and beta subtypes in clinical breast cancer

International Journal of Cancer

Volumn 86, Issue 3, 2000, Pages 209-212

  Knowlden, Janice M ^a   Gee, Julia M W ^a   Robertson, John F R ^b   Ellis, Ian O ^b   Nicholson, Robert I ^a  

^a Tenovus Inst Cancer Res   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; ESTROGEN RECEPTOR; RNA;

ARTICLE; BREAST CANCER; CANCER GROWTH; CELL DIFFERENTIATION; HUMAN; HUMAN TISSUE; MITOSIS RATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; BREAST TUMOR; CANCER STAGING; CHEMISTRY; FEMALE; GENETICS; IMMUNOHISTOCHEMISTRY; PATHOLOGY; POLYMERASE CHAIN REACTION;

BREAST NEOPLASMS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; RNA, MESSENGER; RNA, NEOPLASM;

EID: 0034688929     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0215(20000320)89:2<209::aid-ijc17>3.0.co;2-6     Document Type: Article

References (28)

1. CHRYSOGELOS, S.A., YARDEN, R.I., LAUBER, A.H. and MURPHEY, J.M., Mechanisms of EGF receptor regulation in breast cancer cell. Breast Cancer Res. Treat., 31, 227-236 (1994).
2. COWLEY, S.M., HOARE, S., MOSSELMAN, S. and PARKER, M.G., Oestrogen receptors α and β form heterodimers on DNA. J. biol Chem., 272, 19858-19862 (1997).
3. DOTZLAW, H., LEYGUE, E., WATSON, P.H. and MURPHEY, L.C., Expression of oestrogen receptor-beta in human breast tumours. J. clin. Endocrinol. Metab., 82, 2371-2374 (1997).
4. DOTZLAW, H., LEYGUE, E., WATSON, P.H. and MURPHEY, L.C., Oestrogen receptor-β messenger RNA expression in human breast tumour biopsies: relationship to steroid receptor status and regulation by progestins. Cancer Res., 59, 529-532 (1999).
5. ENMARK, E., PELTO-HUIKKO, M., GRANDIEN, K., LAGERCRANTZ, S., LAGERCRANTZ, J., FRIED, G., NORDENSKJOLD, M. and GUSTAFSSON, J., Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern. J. clin. Endocrinol. Metab., 82, 4258-4265 (1997).
6. FAVONI, R.E. and DE CUPIS, A., Steroidal and nonsteroidal oestrogen antagonists in breast cancer: basic and clinical appraisal. Trends Pharmacol Sci., 19, 406-415 (1998).
7. GEE, J.M.W., MCCLELLAND, R.A. and NICHOLSON, R.I., Growth factors and endocrine sensitivity in breast cancer. In J.R. Pasqualini and B.S. Katzenellenbogen (eds.), Molecular and clinical endocrinology, pp. 169-171, M. Dekker, New York (1996).
8. HAYBITTLE, J.L., BLAMEY, R.W., ELSTON, C.W., JOHNSON, J., DOYLE, P.J., CAMPBELL, F.C., NICHOLSON, R.I. and GRIFFITH, K., A prognostic index in primary breast cancer. Brit. J. Cancer, 45, 361-366 (1982).
9. KNOWLDEN, J.M., GEE, J.M.W., BRYANT, S., MCCLELLAND, R.A., MANNING, D.L., MANSEL, R., ELLIS, I.O., BLAMEY, R.W., ROBERTSON, J.F.R. and NICHOLSON, R.I., The use of reverse transcription-polymerase chain reaction (RT-PCR) methodology to detect oestrogen regulated gene expression in all breast cancer specimens. Clin. Cancer. Res., 3, 2165-2172 (1997).
10. KUIPER, G.G.J.M., ENMARK, E., PELTO-HUIKKO, M., NILSSON, S. and GUSTAFSSON, J.A., Cloning of a novel oestrogen receptor expressed in rat prostate and ovary. Proc. nat. Acad. Sci. (Wash.), 93, 5925-5930 (1996).
11. LEYGUE, E., DOTZLAW, H., WATSON, P.H. and MURPHEY, L.C., Altered estrogen receptor α and β messenger RNA expression during human breast tumorigenesis. Cancer Res., 58, 3197-3201 (1998).
12. MCCARTY, K.S., MILLER, L.S., COX, E.B., KONRATH, J. and MCCARTY, K.S., Oestrogen receptor analysis: correlation of biochemical and immunocytochemical methods using monoclonal antireceptor antibodies. Arch. Pathol. Lab. Med., 109, 716-721 (1985).
13. MOORE, J.T., MCKEE, D.D., SLENTZ-KESLER, K., MOORE, L.B., JONES, S.A., HORNE, E.L., SU, J., KLIEWER, S.A., LEHMANN, J.M. and WILLSON, T.M., Cloning and characterization of human estrogen receptor β isoforms. Biochem. biophys. Res. Comm., 247, 75-78 (1998).
14. MOSSELMAN, S., POLMAN, J. and DUKEMA, R., ERβ: identification and characterization of a novel oestrogen receptor. FEBS. Lett., 392, 49-53 (1996).
15. NAKSHATRI, H., BHAT-NAKSHATRI, P., MARTIN, D.A., GOULET, R.J. and SLEDGE, G.W., JR., Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol. cell. Biol., 17, 3629-3639 (1997).
16. NICHOLSON, R.I., BOUZUBAR, K.W., WALKER, K.J., MCCLELLAND, R., DIXON, A.R., ROBERTSON, J.F.R., ELLIS, I.O. and BLAMEY, R.W., Hormone sensitivity in breast cancer: influence of heterogeneity of oestrogen receptor expression and cell proliferation. Europ. J. Cancer, 27, 908-913 (1991).
17. NICHOLSON, R.I., GEE, J.M.W., JONES, H., HARPER, M.E., WAKELING, A.E., WILLSHER, P. and ROBERTSON, J.F.R., erbB signalling and endocrine sensitivity of human breast cancer. In R.B. Lichtner and R.H. Harkins (eds.), EGF receptor in tumour growth and progression, pp. 105-128, Springer, Boston (1997).
18. NICHOLSON, R.I., MCCLELLAND, R.A., FINLAY, P., EATON, C.L., GULLICK, W.L., DIXON, A.R., ROBERTSON, J.F.R., ELLIS, I.O. and BLAMEY, R.W., Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity. Europ. J Cancer, 29A, 1018-1023 (1993).
19. NICHOLSON, R.I., MCCLELLAND, R.A. and GEE, J.M.W., Steroid hormone receptors and their clinical significance in cancer. J. clin. Pathol., 48, 890-895 (1995).
20. NICHOLSON, R.I., MCCLELLAND, R.A., GEE, J.M.W., MANNING, D.L., CANNON, P., ROBERTSON, J.F.R., ELLIS, I.O. and BLAMEY, R.W., Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy. Breast. Cancer. Res. Treat., 29, 117-125 (1994).
21. PAECH, K., WEBB, P., KUIPER, G.G.J.M., NILSSON, S., GUSTAFSSON, J.-A., KUSHNER, P.J. and SCANLAN, T.S., Differential ligand activation of oestrogen receptors ERα and ERβ at AP1 sites. Science, 277, 1508-1510 (1997).
22. PARKER, M.G., Transcriptional activation by oestrogen receptors. Biochem. Soc. Symp., 63, 45-50 (1998).
23. PHILIPS, A., CHALBOS, D. and ROCHEFORT, H., Estradiol increases and anti-oestrogens antagonize the growth factor-induced activator protein -1 activity in MCF-7 breast cancer cells without affecting c-fos and c-jun synthesis. J. biol. Chem., 268, 14103-14108 (1993).
24. SHIBATA, H., SPENCER, T.E., ONATE, S.A., JENSTER, G., TSAI, S.Y., TSAI, M.J. and O'MALLEY, B.W., Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action. Rec. Progr. Hormone Res., 52, 142-165 (1997).
25. SPEIRS, V., PARKES, A.T., KERIN, M.J., WALTON, D.S., CARLETON, P.J., FOX, J.N. and ATKIN, S.L., Coexpression of oestrogen receptor α and β: poor prognostic factors in human breast cancer. Cancer Res., 59, 525-528 (1999).
26. VLADSUSIC, E.A., HORNBY, A.E., GUERRA-VLADUSIC, F.K. and LUPU, R., Expression of oestrogen β messenger RNA variant in breast cancer. Cancer Res., 58, 210-214 (1998).
27. WATANABE, T., INOUE, S., OGAWA, S., ISHII, Y., HIROI, H., IKEDA, K., ORIMO, A. and MURAMATSU, M., Agonistic effect of tamoxifen is dependent on cell type, ERE-promotor context and estrogen receptor subtype: functional differences between estrogen receptors α and β. Biochem. biophys. Res. Comm., 236, 140-145 (1997).
28. WILLIAMS, M.R., BLAMEY, R.W., TODD, J.H., ELSTON, C.W. and NICHOLSON, R.I., Histological grade in predicting response to endocrine treatment. Breast Cancer Res. Treat., 8, 165-166 (1986).