Vertical-scanning mutagenesis of a critical tryptophan in the 'minor groove binding track' of HIV-1 reverse transcriptase. Major groove DNA adducts identify specific protein interactions in the minor groove

Journal of Biological Chemistry

Volumn 275, Issue 20, 2000, Pages 15025-15033

  Latham, Gary J ^a,c   Forgacs, Eva ^a   Beard, William A ^b   Prasad, Rajendra ^b   Bebenek, Katarzyna ^b   Kunkel, Thomas A ^b   Wilson, Samuel H ^b   Lloyd, R Stephen ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c APPLIED BIOSYSTEMS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA A; DNA B; GLYCINE; RNA DIRECTED DNA POLYMERASE; TRYPTOPHAN; VIRUS ENZYME;

ARTICLE; BASE PAIRING; DNA ADDUCT; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; VIRUS REPLICATION;

ADENINE; ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BINDING SITES; CONSENSUS SEQUENCE; EPOXY COMPOUNDS; GLYCINE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; STEREOISOMERISM; TEMPLATES, GENETIC; TRYPTOPHAN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034686025     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M000279200     Document Type: Article

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