Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain

Journal of Cell Biology

Volumn 150, Issue 6, 2000, Pages 1399-1409

  Crawford, Gregory E ^a   Faulkner, John A ^a   Crosbie, Rachelle H ^c,e   Campbell, Kevin P ^c   Froehner, Stanley C ^d   Chamberlain, Jeffrey S ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dystrobrevin; Dystrophin; mdx mice; Muscular dystrophy; Syntrophin

Indexed keywords

ACTIN; DYSTROBREVIN; DYSTROPHIN; ISOPROTEIN; LAMININ; SIGNAL PEPTIDE; SYNTROPHIN; UNCLASSIFIED DRUG; UTROPHIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSKELETON; DUCHENNE MUSCULAR DYSTROPHY; EXTRACELLULAR MATRIX; MOUSE; MUSCLE CONTRACTION; MUSCLE FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE;

ACTINS; ANIMALS; BINDING SITES; CELL NUCLEUS; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; DYSTROPHIN; DYSTROPHIN-ASSOCIATED PROTEINS; EXONS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MICE, TRANSGENIC; MICROSOMES; MUSCLE CONTRACTION; MUSCLE FIBERS; MUSCLE PROTEINS; MUSCULAR DYSTROPHIES; NEUROPEPTIDES; PROTEIN STRUCTURE, TERTIARY; UTROPHIN;

ANIMALIA; MUS MUSCULUS;

EID: 0034683567     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.6.1399     Document Type: Article

References (82)

1. Mouse α1- and β2-syntrophin gene structure, chromosome localization, and homology with a discs large domain
2. Syntrophin binds to an alternatively spliced exon of dystrophin
3. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives
4. Structure and mutation of the dystrophin gene
5. Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice
6. Characterization of the tyrosine phosphorylation and distribution of dystrobrevin isoforms
7. Human and murine dystrophin mRNA transcripts are differentially expressed during skeletal muscle, heart, and brain development
8. Coiled-coil regions in the carboxy-terminal domains of dystrophin and related proteins: Potentials for protein-protein interactions
9. Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein
10. Beta-dystrobrevin, a member of the dystrophin-related protein family
11. Aging normal and dystrophic mouse muscle: Analysis of myogenicity in cultures of living single fibers
12. β-Sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex
13. Knocking signalling out of the dystrophin complex
14. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains
15. Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice
16. Association of the Mr 58,000 postsynaptic protein of electric tissue with Torpedo dystrophin and the Mr 87,000 postsynaptic protein
17. Muscular dystrophy in mdx mice despite lack of neuronal nitric oxide synthase
18. Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity
19. Dp71 can restore the dystrophin-associated glycoprotein complex in muscle but fails to prevent dystrophy
20. mdx Muscle pathology is independent of nNOS perturbation
21. Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice
22. Direct binding of Torpedo syntrophin to dystrophin and the 87 kDa dystrophin homologue
23. Membrane organization of the dystrophin-glycoprotein complex
24. A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin
25. The functional status of dystrophic muscles and functional recovery by skeletal muscles following myoblast transfer
26. Alternative splicing of human dystrophin mRNA generates isoforms at the carboxy terminus
27. A postsynaptic Mr 58,000 (58K) protein concentrated at acetylcholine receptor-rich sites in Torpedo electroplaques and skeletal muscle
28. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins
29. Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies
30. Maturation and maintenance of the neuromuscular synapse: Genetic evidence for roles of the dystrophin-glycoprotein complex
31. Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin
32. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha 1-syntrophin: A mechanism for specific substrate recognition
33. Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix
34. Identification and characterization of the dystrophin anchoring site on β-dystroglycan
35. alpha1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration
36. Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals
37. Syntrophin isoforms at the neuromuscular junction: Developmental time course and differential localization
38. A housekeeping type promoter, located in the 3' region of the Duchenne muscular dystrophy gene, controls the expression of Dp71, a major product of the gene
39. Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases
40. Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting
41. Characterization of dystrophin and utrophin diversity in the mouse
42. Contractile properties of diaphragm muscle segments from old mdx and old transgenic mdx mice
43. Contraction-induced injury to single permeabilized muscle fibers from mdx, transgenic mdx, and control mice
44. Construction of plasmids that express E. coli β-galactosidase in mammalian cells
45. Visualization of dystrophic muscle fibers in Mdx mouse by vital staining with evans blue: Evidence of apoptosis in dystrophin-deficient muscle
46. Restoration of dystrophin-associated proteins in skeletal muscle of mdx mice transgenic for dystrophin gene
47. Complementary DNA probes for the Duchenne muscular dystrophy locus demonstrate a previously undetectable deletion in a patient with dystrophic myopathy, glycerol kinase deficiency, and congenital adrenal hypoplasia
48. Characterisation of alpha-dystrobrevin in muscle
49. Autosomal recessive limb-girdle muscular dystrophy, LGMD2F, is caused by a mutation in the δ sarcoglycan gene
50. Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy
51. Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx mice
52. Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma
53. Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle
54. β2-syntrophin: Localization at the neuromuscular junction in skeletal muscle
55. Differential association of syntrophin pairs with the dystrophin complex
56. β-dystrobrevin, a new member of the dystrophin family: Identification, cloning, and protein associations
57. Differential membrane localization and intermolecular associations of alpha-dystrobrevin isoforms in skeletal muscle
58. Dystrophin protects the sarcolemma from stresses developed during muscle contraction
59. Identification and characterization of a novel member of the dystrobrevin gene family
60. Prevention of dystrophic pathology in mdx mice by a truncated dystrophin isoform
61. Forced expression of dystrophin deletion constructs reveals structure-function correlations
62. Dystrophin and utrophin influence fiber type composition and post-synaptic membrane structure
63. Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane
64. Dystrobrevin and dystrophin: An interaction through coiled-coil motifs
65. Targeted inactivation of Dp71, the major non-muscle product of the DMD gene: Differential activity of the Dp71 promoter during development
66. Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels
67. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy
68. Animal models for muscular dystrophy show different patterns of sarcolemmal disruption
69. Molecular pathogenesis of muscle degeneration in the delta-sarcoglycan-deficient hamster
70. Glycoprotein-binding site of dystrophin is confined to the cysteine-rich domain and the first half of the carboxy-terminal domain
71. Mammalian α1- and β1-syntrophin bind to the alternative splice-prone region of the dystrophin COOH terminus
72. Expression of a dystrophin-related protein associated with the skeletal muscle cell membrane
73. Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle
74. Apo-dystrophin-3: A 2.2kb transcript from the DMD locus encoding the dystrophin glycoprotein binding site
75. The mutant mdx: Inherited myopathy in the mouse. Morphological studies of nerves, muscles and end-plates
76. The 87K postsynaptic membrane protein from torpedo is a protein-tyrosine kinase substrate homologous to dystrophin
77. Identification of α-syntrophin binding to syntrophin triplet, dystrophin, and utrophin
78. Aquaporin-4 is absent at the sarcolemma and at perivascular astrocyte endfeet in alpha 1-syntrophin knock-out mice
79. Biochemical evidence for association of dystrobrevin with the sarcoglycan-sarcospan complex as a basis for understanding sarcoglycanopathy
80. Dystrophin-associated protein A0 is a homologue of the Torpedo 87K protein
81. The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle