Rho, tyrosine kinase, Ca2+, and junctions in endothelial hyperpermeability

Circulation Research

Volumn 87, Issue 4, 2000, Pages 268-271

  Alexander, J Steven ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Barrier; Myosin; Permeability; Thrombin

Indexed keywords

PROTEIN TYROSINE KINASE; RHO FACTOR;

ATHEROSCLEROSIS; BLOOD VESSEL PERMEABILITY; EDITORIAL; ENZYME ACTIVITY; GAP JUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VASCULAR ENDOTHELIUM;

EID: 0034682936     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.4.268     Document Type: Editorial

References (48)

1. Pathophysiology of ischaemia-reperfusion injury
2. Ischemia-reperfusion: Mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease
3. Microvascular dysfunction in sepsis
4. Endothelial gaps as sites for plasma leakage in inflammation
5. The effect of histamine and serotonin on vascular permeability: An electron microscope Study
6. Open junctions in the endothelium of the postcapillary venules of the diaphragm
7. Regulation of endothelial gap formation and barrier dysfunction: Role of myosin light chain phosphorylation
8. Myosin light chain kinase-regulated endothelial cell contraction: The relationship between isometric tension, actin polymerization, and myosin phosphorylation
9. Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: Role of protein kinases, calcium, and RhoA
10. Biochemical regulation of the nonmuscle myosin light chain kinase isoform in bovine endothelium
11. Rho A inactivation enhances endothelial barrier function
12. Rac and Rho
13. Activation of RhoA by thrombin in endothelial hyperpermeability: Role of Rho kinase and protein tyrosine kinases
14. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: Role of Rho proteins in endothelial barrier function
15. Effects of cytotoxic necrotizing factor 1 and lethal toxin on actin cytoskeleton and VE-cadherin localization in human endothelial cell monolayers
16. Mechanisms of ionomycin-induced endothelial cell barrier dysfunction
17. Phosphorylation and activation of myosin by Rhoassociated kinase (Rho-kinase)
18. Thrombin inhibits myosin light chain dephosphorylation in endothelial cells
19. Myosin light chain kinase in endothelium: Molecular cloning and regulation
20. Immunocytochemical detection and spatial distribution of myosin light-chain kinase in pmimplantation mouse embryos
21. Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60src
22. Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2
23. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells
24. 2+ Ca /calmodulin-dependent phosphatase 2B in thrombin induced endothelial cell contractile responses
25. Regulation of endothelial gap formation and barrier function by myosin-associated phosphatase activities
26. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
27. 2+]i elevation in human dermal fibroblasts
28. Role of tyrosine phosphorylation in thrombin-induced endothelial cell contraction and barrier function
29. Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphlngosine 1-phosphate, a bioactive lysophospholipid released from activated platelets
30. Ionomycin and PDBU increase MDCK monolayer permeability independently of myosin light chain phosphorylation
31. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
32. Regulation of cadherin function by Rho and Rac: Modulation by junction maturation and cellular context
33. Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion
34. Histamine alters cadherin-mediated sites of endothelial adhesion
35. Adherent neutrophils activate endothelial myosin light chain kinase: Role in transendothelial migration
36. Endothelial myosin light chain kinase regulates neutrophil migration across human umbilical vein endothelial cell monolayer
37. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a Rho-dependent pathway
38. ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells
39. The vesiculo-vacuolar organelle (VVO): A distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation
40. Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea-pig, mouse and rat: Many are transcellular pores
41. Pathways of macromolecular tracer transport across venules and small veins: Basis for the hyperpermeability of tumor blood vessels
42. Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP
43. Stimulation of platelets and endothelial cells by mildly oxidized LDL proceeds through activation of lysophosphatidic acid receptors and the Rho/Rho kinase pathway: Inhibition by lovastatin
44. Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration
45. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: Functional significance of the NOS caveolin binding domain in vivo
46. Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains
47. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells: Role of geranylgeranylation and Rho proteins
48. Rho-kinase inhibitor retards migration and in vivo dissemination of human postrate cancer cells