Cloning and characterization of the gene encoding mouse IκBβ

Gene

Volumn 247, Issue 1-2, 2000, Pages 279-286

  Budde, Lucy M ^a   Ghosh, Sankar ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genomic sequence; Intron exon structure; I Bbeta; NF kappa B

Indexed keywords

ANKYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN PRECURSOR;

ARTICLE; EVOLUTION; EXON; GENE STRUCTURE; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA; EXONS; GENES; I-KAPPA B PROTEINS; INTRONS; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID;

RODENTIA;

EID: 0034682038     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00051-2     Document Type: Article

References (31)

1. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., Struhl K. Current Protocols in Molecular Biology. vol. I:1991;Greene Publishing Associates/Wiley-Interscience, New York, NY.
2. Baeuerle P.A., Henkel T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:1994;141-179.
3. Baldwin A.S. Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:1996;649-681.
4. Beg A.A., Baldwin A.S. Jr. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7:1993;2064-2070.
5. Dobrzanski P., Ryseck R.P., Bravo R. Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100. Oncogene. 10:1995;1003-1007.
6. Dushay M.S., Asling B., Hultmark D. Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc. Natl. Acad. Sci. USA. 93:1996;10343-10347.
7. Franzoso G., Bours V., Park S., Tomita-Yamaguchi M., Kelly K., Siebenlist U. The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition. Nature. 359:1992;339-342.
8. Ghosh S., May M.J., Kopp E.B. NF-κB and rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:1998;225-260.
9. Grilli M., Chiu J.J.-S., Lenardo M.J. NF-κB and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1993;1-62.
10. Huxford T., Huang D., Malek S., Ghosh G. The crystal structure of the IκBa/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell. 95:1998;759-770.
11. Inoue J., Kerr L.D., Kakizuka A., Verma I.M. IκBg, a 70 kDa protein identical to the C-terminal half of p110 NF-κB: a new member of the IκB family. Cell. 68:1992;1109-1120.
12. Ito C.Y., Adey N., Bautch V.L., Baldwin A.S. Jr. Structure and evolution of the human IκBa gene. Genomics. 29:1995;490-495.
13. Jacobs M.D., Harrison S.C. Structure of an IκBa/NF-κB complex. Cell. 95:1998;749-758.
14. Kopp E.B., Ghosh S. NF-κB and rel proteins in innate immunity. Adv. Immunol. 58:1995;1-27.
15. LeBeau M.M., Ito C.Y., Cogswell P., Espinosa R., Fernald A.A., Baldwin A.S. Jr. Chromosomal localization of the genes encoding the p50/p105 subunits of NF-κB and IκB/MAD-3 inhibitor of the NF-κB to 4q24 and 14q13, respectively. Genomics. 14:1992;529-531.
16. Mathew S., Murty V.V.V.S., Dalla-Favera R., Chaganti R.S.K. Chromosomal localization of genes encoding the transcription factors c-rel, NF-κB p50, NF-κB p65 and lyt-10 by fluorescence in situ hybridization. Oncogene. 8:1993;191-193.
17. May M.J., Ghosh S. Rel/NF-κB and IκB proteins: an overview. Semin. Cancer Biol. 8:1997;63-73.
18. Mercurio F., Manning A.M. Multiple signals converging on NF-κB. Curr. Opin. Cell Biol. 11:1999;226-232.
19. Naumann M., Nieters A., Hatada E.N., Scheidereit C. NF-κB precursor p100 inhibits nuclear translocation of NF-κB/Rel factors. Oncogene. 8:1993;2275-2281.
20. Naumann M., Wulczyn F.G., Scheidereit C. The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO J. 12:1993;213-222.
21. Nolan G.P., Baltimore D. The inhibitory ankyrin and activator rel proteins. Curr. Biol. 2:1992;211-220.
22. Nolan G.P., Fujita T., Bhatia K., Huppi K., Liou H.C., Scott M.L., Baltimore D. The bcl-3 proto-oncogene encodes a nuclear IκB-like molecule that preferentially interacts with NF-κB p50 in a phosphorylation-dependent manner. Mol. Cell. Biol. 13:1993;3557-3566.
23. Ohno H., Takimoto G., McKeithan T.W. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell. 71:1990;991-997.
24. Perkins N.D. Achieving transcriptional specificity with NF-κB. Int. J. Biochem. Cell Biol. 29:1997;1433-1448.
25. Rice N.R., MacKichan M.L., Israel A. The precursor of NF-κB p50 has IκB-like functions. Cell. 71:1992;243-253.
26. Scheinman R.I., Beg A.A., Baldwin A.S. NF-κB p100 (Lyt-10) is a component of H2TF1 and can function as an IκB-like molecule. Mol. Cell. Biol. 13:1993;6089-6101.
27. Schmid R.M., Perkins N.D., Duckett C.S., Andrews P.C., Nabel G.J. Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65. Nature. 352:1991;733-736.
28. Thompson J.E., Phillips R.J., Erdjument-Bromage H., Tempst P., Ghosh S. IκBβ regulates the persistent response in a biphasic activation of NF-κB. Cell. 80:1995;573-582.
29. Whiteside S.T., Epinat J.-C., Rice N.R., Israel A. I kappa B epsilon, a novel member of the IκB family controls RelA and cRel NF-κB activity. EMBO J. 16:1997;1413-1426.
30. Whiteside S.T., Israel A. IκB proteins: structure, function and regulation. Semin. Cancer Biol. 8:1997;75-82.
31. Wulczyn F.G., Naumann M., Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB. Nature. 358:1992;597-599.