Arabino-fluorooligonucleotide N3'→P5' phosphoramidates: Synthesis and properties

Tetrahedron Letters

Volumn 41, Issue 12, 2000, Pages 1895-1899

  Schultz, Ronald G ^a   Gryaznov, Sergei M ^a  

^a GERON CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG DNA BINDING; DRUG STABILITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 0034681839     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00056-3     Document Type: Article

References (12)

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3. Ikeda, H.; Fernandez, R.; Wilk, A.; Barchi Jr., J. J.; Huang, X.; Marquez, V. E. Nucleic Acids Res. 1998, 26, 2237-2244; Kois, P.; Tocik, Z.; Spassova, M.; Ren, W.-Y.; Rosenberg, I.; Soler, J. F.; Watanabe, K. A. Nucleosides Nucleotides 1993, 12, 1093-1109.
4. Ikeda, H.; Fernandez, R.; Wilk, A.; Barchi Jr., J. J.; Huang, X.; Marquez, V. E. Nucleic Acids Res. 1998, 26, 2237-2244; Kois, P.; Tocik, Z.; Spassova, M.; Ren, W.-Y.; Rosenberg, I.; Soler, J. F.; Watanabe, K. A. Nucleosides Nucleotides 1993, 12, 1093-1109.
5. Schultz, R. G.; Gryaznov, S. M. Nucleic Acids Res. 1996, 24, 2966-2973.
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8. Czernecki, S.; Valery, J.-M. Synthesis 1991, 239-240.
9. Glinski, R. P.; Khan, M. S.; Kalamas, R. L.; Stevens, C. L.; Sporn, M. B. J. Chem. Soc., Chem. Commun. 1970, 915-916.
10. 3) two hextets at -190.26 and -190.88.
11. R), for co-injected oligonucleotides 12, 13, 9 and 10 (Table 1) was 33.6, 41.5, 42.5 and 46.5 minutes, respectively. At pH 7.2 (10 mM Ma-phosphate buffer), retention times for oligonucleotides 12 and 13 was 23.7 and 23.8 minutes, respectively.
12. Krug, A.; Oretskaya, T. S.; Volkov, E. M.; Cech, D.; Shabarova, Z. A.; Rosenthal, A. Nucleosides Nucleotides 1989, 8, 1473-1483.