Detection of polymorphisms in the prion protein gene in a population of Irish Suffolk sheep

Veterinary Record

Volumn 146, Issue 12, 2000, Pages 335-338

  O'Doherty, E ^a   Aherne, M ^a   Ennis, S ^a   Weavers, E ^b   Hunter, N ^c   Roche, J F ^a   Sweeney, T ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b Central Veterinary Laboratory   (Ireland)

^c INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OVIS ARIES;

ANIMAL; ARTICLE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; IRELAND; MALE; PEDIGREE; POLYMERASE CHAIN REACTION; PRION; SCRAPIE; SHEEP;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; IRELAND; MALE; PEDIGREE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PRIONS; SCRAPIE; SHEEP;

EID: 0034681672     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.146.12.335     Document Type: Article

References (24)

1. BASLER, K., OESCH, B., SCOTT, M., WESTAWAY, D., WÄLCHLI, M., GROTH, D. F., McKINLEY, M. P., PRUSINER, S. B. & WEISSMAN, C. (1986) Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell 46, 417-428
2. BELT, B. G. M., MUILEMAN, I. H., SCHREUDER, B. E. C., BOS-DE RUIJTER, J., GIELKENS, A. L. K. & SMITS, M. A. (1995) Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie. Journal of General Virology 76, 509-517
3. BOSSERS, A., SCHREUDER, B. E. C., MUILEMAN, I. H., BELT, P. B. G. & SMITS, M. A. (1996) PrP genotype contributes to determining survival times of sheep with natural scrapie. Journal of General Virology 77, 2669-2673
4. BÜELER, H., AGUZZI, A., SAILER, A., GREINER, R-A., AUTENRIED, P., AGUET, M. & WEISSMAN, C. (1993) Mice devoid of PrP are resistant to scrapie. Cell 73, 1339-1347
5. CASTIGLIONI, B., COMINCINI, S., DRISALDI, B., MOTTA, T., MARCHITELLI, C., VALENTINI, A., PAGNACCO, G., LEONE, P. & FERRETTI, L. (1998) Physical mapping of the prion genes in cattle, sheep and man by fluorescence in situ hybridization. Proceedings of the 6th World Congress on Genetics Applied to Livestock Production 27, 343-346
6. CLOUSCARD, C., BEAUDRY, P., ELSEN, J. M., MILAN, D., DUSSAUCY, M., BOUNNEAU, C., SCHELCHER, F., CHATELAIN, J., LAUNEY, J. M. & LAPLANCHE, J. L. (1995) Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie. Journal of General Virology 76, 2097-2101
7. DAWSON, M. (1997) PrP genotyping (scrapie gene testing) as an aid to the control of scrapie. State Veterinary Journal 7, 16-17
8. DAWSON, M., HOINVILLE, L., HOSIE, B. D. & HUNTER, N. (1998) Guidance on the use of PrP genotyping as an aid to the control of scrapie. Veterinary Record 142, 623-625
9. GOLDMANN, W., HUNTER, N., BENSON, G., FOSTER, J. D. & HOPE, J. (1991) Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep for different alleles of the Sip gene. Journal of General Virology 72, 2411-2417
10. GOLDMANN, W., HUNTER, N., FOSTER, J. D., SALBAUM, M., BEYREUTHER, K. & HOPE, J. (1990) Two alleles of a neural protein gene linked to scrapie in sheep. Proceedings of the National Academy of Sciences USA 87, 2476-2480
11. HUNTER, N., FOSTER, J. D., GOLDMANN, W., STEAR, M. J., HOPE, J. & BOSTOCK, C. (1996) Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. Archives of Virology 141, 809-824
12. HUNTER, N., GOLDMANN, W., FOSTER, J. D., CAIRNS, D. & SMITH, G. (1997a) Natural scrapie and PrP genotype: case-control studies in British sheep. Veterinary Record 141, 137-140
13. HUNTER, N., GOLDMANN, W., SMITH, G. & HOPE, J. (1994) The association of a codon 136 PrP gene variant with the occurrence of natural scrapie. Archives of Virology 137, 171-177
14. HUNTER, N., MOORE, L., HOSIE, B. D., DINGWALL, W. S. & GREIG, A. (1997b) Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland. Veterinary Record 140, 59-63
15. IKEDA, T., HORIUCHI, M., ISHIGURO, N., MURAMATSU, Y., KAI-UWE, G. D. & SHINAGAWA, M. (1995) Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in Japan. Journal of General Virology 76, 2577-2581
16. JUNGHANS, F., TUEFEL, B., BUSCHMANN, A., STENG, G. & GROSCHUP, M. H. (1998) Genotyping of German sheep with respect to scrapie susceptibility. Veterinary Record 143, 340-341
17. LAPLANCHE, J. L., CHATELAIN, J., BEAUDRY, P., DUSSAUCY, M., BONNEAU, C. & LAUNAY, J. M. (1993a) French autochthonous scrapied sheep without the 136Val PrP polymorphism. Mammalian Genome 4, 463-464
18. LAPLANCHE, J. L., CHATELAIN, J., WESTAWAY, D., THOMAS, S., DUSSAUCY, M., BRUGERE-PICOUX, J. & LAUNAY, J. M. (1993b) PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. Genomics 15, 30-37
19. LOFTUS, B., MONKS, E., HANLON, J., WEAVERS, E. & ROGERS, M. (1999) Prion protein genotypes of Suffolk-type sheep representative of natural scrapie in Ireland. Irish Veterinary Journal 52, 81-85
20. Sc in nictitating membrane lymphoid tissue of sheep. Veterinary Record 142, 489-491
21. O'ROURKE, K. I., MELCO, R. P. & MICKELSON, J. R. (1996) Allelic frequencies of an ovine scrapie susceptibility gene. Animal Biotechnology 7, 155-162
22. RACE, R. & CHESEBRO, B. (1998) Scrapie infectivity found in resistant species. Nature 392, 770
23. VAN KEULEN, L. M. J., SCHREUDER, B. E. C., MELEON, R. H., MOOIJHARKES, G., VROMANS, M. E. W. & LANGEVELD, J. P. M. (1996) Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. Journal of Clinical Microbiology 34, 1228-1231
24. WESTAWAY, D., ZULIAIN, V., COOPER, C. M., DA COSTA, M., NEWMAN, S., JENNY, A. L., DETWILER, L. & PRUSINER, S. B. (1994) Homozygosity for prior protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie. Genes and Development 8, 959-969