Neural science: A century of progress and the mysteries that remain

Cell

Volumn 100, Issue , 2000, Pages S1-S55

  Albright, Thomas D ^a   Jessell, Thomas M ^b   Kandel, Eric R ^b   Posner, Michael I ^c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b College of Physicians and Surgeons Columbia University ^*  (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; BRAIN FUNCTION; CELL ACTIVITY; CONSCIOUSNESS; EMOTION; GENE EXPRESSION; IMAGE ANALYSIS; INFORMATION PROCESSING; MEMBRANE TRANSPORT; MENTAL PERFORMANCE; MOLECULAR BIOLOGY; NERVE CONDUCTION; NERVE FIBER GROWTH; NERVE FIBER MEMBRANE POTENTIAL; NERVE TRACT; NEUROANATOMY; NEUROLOGIC DISEASE; NEUROPSYCHOLOGY; NEUROTRANSMISSION; PRIORITY JOURNAL; REVIEW; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION; VISUAL SYSTEM;

EID: 0034681271     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80912-5     Document Type: Review

References (363)

1. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
2. The analysis of the nervous system. Sherrington Memorial Lecture
3. Form-cue invariant motion processing in primate visual cortex
4. Cortical processing of visual motion
5. Visual motion perception
6. Columnar organization of directionally selective cells in visual area MT of the macaque
7. Encoding of spatial location by posterior parietal neurons
8. Coordinate transformations in the representation of spatial information
9. Rapid remodeling of axonal arbors in the visual cortex
10. Development of individual geniculocortical arbors in cat striate cortex and effects of binocular impulse blockade
11. Voltage gated ion channels and electrical excitability
12. Preferential selection of central pathways by regenerating optic fibers
13. The molecular logic of smell
14. Regulation of vertebrate neural cell fate by transcription factors
15. Summation and inhibition in the frog's retina
16. Single units and sensation: A neuron doctrine for perceptual psychology?
17. Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without a membrane-spanning region
18. Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
19. CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation
20. Pioneer neurones in an insect embryo
21. Model generation and testing to probe neural circuitry in the cingulate cortex of postmortem schizophrenic brains
22. A comparison of electrically and chemically mediated transmission
23. Seeing is relieving: Electrical synapses between visualized neurons
24. Unilateral neglect of representational space
25. Long lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
26. SNARE proteins mediate lipid bilayer fusion
27. Membrane permeability change during inhibitory transmitter action in crustacean muscle
28. Deficient long-term memory in mice with a targeted mutation of the cAMP responsive element binding protein
29. The end-plate potential in mammalian muscle
30. Distinct calcium-independent and calcium-dependent adhesion systems of chicken embryo cells
31. The specification of neuronal identity by graded Sonic hedgehog signaling
32. The recording of potentials from motoneurones with an intracellular electrode
33. Amphibian limb regeneration: Rebuilding a complex structure
34. Ion channel mutations in periodic paralysis and related myotonic diseases
35. Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily
36. A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
37. Cortical plasticity: From synapses to maps
38. The counting Stroop: An interference task specialized for functional neuroimaging - Validation study with functional MRI
39. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting Stroop
40. Presynaptic facilitation revisited: State and time dependence
41. Inhibition of ocular dominance column formation by insusion of NT-4/5 or BDNF
42. Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns
43. Local circuits in primary visual cortex of the macaque monkey
44. Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica
45. The contribution of the anterior cingulate to executive processes in cognition
46. A transient neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis
47. Neuronal mechanisms of habituation and dishabituation of the gill-withdrawal reflex in Aplysia
48. Structure and function of voltage-sensitive ion channels
49. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels
50. Conservation of neurogenic genes and mechanisms
51. The functional architecture of the acetylcholine nicotinic receptor explored by affinity labeling and site directed mutagenesis
52. Functional characterization of a potassium-selective prokaryotic glutamate receptor
53. Rapid reorganization of cortical maps in adult cats following restricted deafferentation in retina
54. Construction of hybrid proteins that migrate retrogradely and transynaptically into the central nervous system
55. Space and attention in parietal cortex
56. Electrical impedance measurements in the squid giant axon during activity
57. Memories of NMDA receptors and LTP
58. From muscle endplate to brain synapses: A short history of synapses and agonist activated ion channels
59. Tracking fiber pathways in the living human brain
60. Chronometric studies of the rotation of visual images
61. Selective anti divided attention during visual discriminations of shape, color, and speed: Functional anatomy by positron emission tomography
62. Frontoparietal cortical networks for directing attention and the eye to visual locations: Identical, independent, or overlapping neural systems?
63. The emergence of modern neuroanatomy and developmental neurobiology
64. A brief history of synapses and synaptic transmission
65. Regressive events in neurogenesis
66. The emergence of modern neuroscience: Some implications for neurology and psychiatry
67. The role of visual experience in the development of columns in cat visual cortex
68. Consciousness and neuroscience
69. Perceptual learning of spatial localization: Specificity for orientation, position, and context
70. Development of ocular dominance columns in the absence of retinal input
71. DCC and netrins
72. Quantal components of the end-plate potential
73. Semantic encoding and retrieval in the left inferior prefrontal cortex: A functional MRI study of task difficulty and process specificity
74. Neural mechanisms of selective visual attention
75. Subventricular zone astrecytes are neural stem cells in the adult mammalian brain
76. + conduction and selectivity
77. The Eph family in retinal axon guidance
78. Reciprocal suppression of regional blood flow during emotional versus higher cognitive processes: Implications for interactions between emotion and cognition
79. Gene discovery in Drosophila: New insights for learning and memory
80. Presynaptic inhibition at the crayfish neuromuscular junction
81. Disorganization of behavior after frontal lobe damage
82. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
83. The changing view of neural specificity
84. Cell adhesion molecules
85. Temporal binding, binocular rivalry, and consciousness
86. An analysis of the end-plate potential recorded with an intra-cellular electrode
87. Spontaneous subthreshold activity at motor nerve endings
88. Distributed hierarchical processing in the primate cerebral cortex
89. Genetics of synaptic vesicle function: Toward the complete functional anatomy of an organelle
90. Accumulation of acetylcholine receptors and acetylcholinesterase at newly formed nerve-muscle synapses
91. The interpretation of spinal reflexes in terms of present knowledge of nerve conduction
92. Environmental specification of neuronal connectivity
93. Synaptic tagging and long-term potentiation
94. Images of psychopathology
95. Columns for visual features of objects in monkey inferotemporal cortex
96. Steps in the production of motoneuron spikes
97. Mechanism of nerve impulse transmission at a crayfish synapse
98. Mental rotation of the neuronal population vector
99. Receptive field dynamics in adult primary visual cortex
100. Supplementary motor area structure and function: Review and hypothesis
101. Nogo in nerve regeneration
102. Activity of superior colliculus in behaving monkey. II. Effect of attention on neuronal responses
103. Stimulating issues in cortical map development
104. Developmental mechanisms that generate precise patterns of neuronal connectivity
105. Transcriptional control of neurotransmitter phenotype
106. Synchronization of oscillatory responses in visual cortex: A plausible mechanism for scene segmentation
107. Coding of visual space by premotor neurons
108. Molecular neurobiology and genetics: Investigation of neural function and dysfunction
109. Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss
110. Visual functions of inferotemporal cortex
111. Visual receptive fields of neurons in inferotemporal cortex of the monkey
112. + channel β subunit
113. Cells perception of position in a concentration gradient
114. Axon guidance: Starting and stopping with slit
115. Cell death in the development of the lateral motor column of the chick embryo
116. The history of the discovery of the nerve growth factor
117. Proliferation differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions
118. Of mice and memory
119. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy
120. Formation and function of Spemann's organizer
121. The response of single optic nerve fibers of the vertebrate eye to illumination of the retina
122. Nerve impulses from single receptors in the eye
123. Control of thalamocortical afferent rearrangement by postsynaptic activity in developing visual cortex
124. Programmed cell death in Caenorhabditis elegans
125. Fate of tritiated noradrenaline at sympathetic nerve endings
126. Synaptic vesicle exocytosis revealed in quick-frozen frog neuromuscular junctions treated with 4-amino-pyridine and given a single electric shock
127. Ion channels: From ideas to reality
128. Evidence for electrical transmission in nerve. Parts I and II
129. Action potentials recorded from inside a nerve fiber
130. The effect of sodium ions on the electrical activity of the giant axon of the squid
131. Measurement of current voltage relations in the membrane of the giant axon of Loligo
132. Regulation of N-methyl-D-aspartate (NMDA) receptor function during the rearrangement of developing neuronal connections
133. Dystrophin abnormalities in Duchenne/Becker muscular dystrophy
134. Dystrophin: The protein product of the Duchenne muscular dystrophy locus
135. Neuropeptides in perspective: The last ten years
136. Disorders of sensation produced by cortical lesions
137. Receptive fields of single neurones in the cat's striate cortex
138. Receptive fields, binocular interaction and functional architecture in the cat's visual cortex
139. Receptive fields of cells in striate cortex of very young, visually inexperienced kittens
140. Binocular interaction in striate cortex of kittens reared with artificial squint
141. Receptive fields and functional architecture of monkey striate cortex
142. Ferrier lecture: Functional architecture of macaque monkey visual cortex
143. Early exploration of the visual cortex
144. Plasticity of ocular dominance columns in the monkey striate cortex
145. The chemoaffinity hypothesis: An appreciation of Roger W. Sperry's contributions to developmental biology
146. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
147. Integrins: A family of cell surface receptors
148. Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus
149. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning
150. Making new connections: Role of Erk/MAP kinase signaling in neuronal plasticity
151. Auxiliary subunits of voltage-gated ion channels
152. Spatial attention and two modes of visual consciousnes
153. Programmed cell death in animal development
154. Identification of a neural Stem cell in the adult mammalian central nervous system
155. Inducible genetic suppression of neuronal excitability
156. Mesoderm induction assays
157. Cellular neurophysiological approaches in the study of learning
158. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
159. Learning perceptual skills: Behavioral probes into adult cortical plasticity
160. The time course of learning a visual skill
161. Increased activity in human visual cortex during directed attention in the absence of visual stimulation
162. The release of neural transmitter substances
163. Scanning laser photostimulation: A new approach for analyzing brain circuits
164. Synaptic activity and the construction of cortical circuits
165. Testing the agrin hypothesis
166. Children's temperament, mothers' discipline, and security of attachment: Multiple pathways to emerging internalization
167. Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence P(CCG)n
168. Discharge patterns and functional organization of mammalian retina
169. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder
170. Neuronal synchrony does not represent texture segregation
171. Pathway selection by chick lumbosacral motoneurons during normal development
172. On the regeneration of pre-ganglionic and post-ganglionic visceral nerve fibers
173. On nerve endings and on special excitable substances in cells
174. Genetic ablation reveals the essential role of the roof plate in dorsal interneuron specification
175. What the frog's eye tells the frog's brain
176. The development of ocular dominance columns in normal and visualy deprived monkeys
177. The nerve growth factor: Its mode of action on sensory and sympathetic nerve cells
178. Regulation of the genes of the bithorax complex in Drosophila
179. The quantal components of the mammalian end-plate potential
180. Analysis of the activity of the chains of internuncial neurons
181. Patterning the vertebrate neuraxix
182. Relationship between intrinsic connections and functional architecture revealed by optical imaging and in vivo targeted biocytin injections in primate striate cortex
183. Conscious and unconscious perception: Experiments on visual masking and word recognition
184. Neurochemistry of attention
185. Synapse-specific transcription-dependent long-term facilitation of the sensory to motor neuron connection in Aplysia: A function for local protein synthesis in memory storage
186. Genetic approaches to memory storage
187. Control of memory formation through regulated expression of a CaMKII transgene
188. A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes
189. The agrin hypothesis
190. Spatial attention and neglect: Parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events
191. Genetics of programmed cell death in C. elegans: Past, present and future
192. A model for the development of simple cell receptive fields and the ordered arrangement of orientation columns through activity-dependent competition between ON- and OFF-center inputs
193. Memory disturbance after bilateral hippocampal lesions
194. Cognitive neuroscience and the study of memory
195. Neurexins: Three genes and 1001 products
196. Visualizing an olfactory sensory map
197. A critical period for macromolecular synthesis in long-term heterosynapfic facilitation in Aplysia
198. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells
199. Modality and topographic properties of single neurons of cat's somatic sensory cortex
200. Cortical neuronal mechanisms in flutter-vibration studied in unanesthetized monkeys. Neuronal periodicity and frequency discrimination
201. Growth cone guidance: First steps towards a deeper understanding
202. Single channel membrane of denervated frog muscle fibers
203. A selective impairment of motion perception following lesions of the middle temporal visual area (MT)
204. Neuronal correlates of a perceptual decision
205. Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs
206. Short historical survey of pattern formation in the endo-mesoderm and the neural anlage in the vertebrates: The role of vertical and planar inductive actions
207. Ecdysone-inducible gene expression in mammalian cells and transgenic mice
208. Attention to action: Willed and automatic control of behavior
209. A molecular view of neurotransmitter regions and ion channels
210. Mutations affecting segment number and polarity in Drosophila
211. Object-centered direction selectivity in macaque supplementary eye field
212. Neuronal cell death and some related regressive phenomena during neurogenesis: A selective historical review and progress report
213. Plasticity and stem cells in the vertebrate nervous system
214. Selective attention in aging and dementia
215. Rapid and efficient fusion of phospholipid vesicles by the α-helical core of a SNARE complex in the absence of an N-terminal regulatory domain
216. The neural basis of implicit movements used in recognizing hand shape
217. Trinucleotide repeats in neurogenetic disorders
218. Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases
219. Neuronal cell death
220. Knock-out mouse models used to study neurobiological systems
221. Attention and primary visual cortex
222. The neuroimaging of human brain function
223. Attention, self-regulation and consciousness
224. Neuroanatomy, circuitry and plasticity of word reading
225. Channelopathies: Ion channel disorders of muscle as a paradigm for paroxysmal disorders of the nervous system
226. The familial periodic paralyses and nondystrophic myotonias
227. Behind the scenes of functional brain imaging: A historical and physiological perspective
228. Practice-related changes in the human brain: Functional anatomy during non-motor learning
229. The Croonian Lecture: La fine structure des centres nerveux
230. The structure and connexions of neurons
231. The complex pathology of trinucleotide repeats
232. Neurotrophic factors and their receptors
233. To see or not to see: The need for attention to perceive changes in scenes
234. Axons from CNS neurons regenerate into PNS grafts
235. Event related functional MRI: Past, present, and future
236. Intranuclear neuronal inclusions: A Common pathogenic mechanism for glutamine-repeat neurogenerative diseases?
237. Temperament and personality: Origins and outcomes
238. The structure of the ligand-binding domain of neurexin I β: Regulation of LNS domain function by alternative splicing
239. RGD and other recognition sequences for integrins
240. Binding properties of a cell adhesion molecule from neural tissue
241. Broca's first two cases: From bumps on the head to cortical convolutions
242. Microstimulation of visual area MT influences perceived direction of motion
243. Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo
244. Development of the vertebrate neuromuscular junction
245. Experiments on special sense localisations in the cortex cerebri of the monkey
246. Computational anatomy and functional architecture of striate cortex: A spatial mapping approcah to perceptual coding
247. Temporally and spatially regulated somatic mutagenesis in mice
248. Structural relationships among genes that control development: Sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila
249. How to study consciousness scientifically
250. Finding a partner in a crowd: Neuronal diversity and synaptogenesis
251. Synchrony unbound: A critical evaluation of the temporal binding hypothesis
252. The diversity of cadherins and implications for a synaptic adhesive code in the CNS
253. Neurotrophins and visual system plasticity
254. Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses
255. The central nervous system
256. Flexor-reflex of the limb, crossed extension reflex, and reflex stepping and standing (cat and dog)
257. CREB and memory
258. Consciousness and the structure of neuronal representations
259. Evidence that the D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder
260. Induction and early amphibian development
261. SNAP receptors implicated in vesicle targeting and fusion
262. Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses
263. Studies of living nerves. II. Activities of ameboid growth cones, sheath cells, and myelin segments, as revealed by prolonged observation of individual nerve fibers in frog tadpoles
264. Induction von embryonolanlagen durch impplantation artfremder organisatoren
265. Effect of 180°rotation of the retinal field on visuomotor coordination
266. Chemoaffinity in the orderly growth of nerve fiber patterns and connections
267. The medial temporal lobe memory system
268. Making a submicroscopic hole in one
269. Neuronal diversity: Too many cell types for comfort?
270. The origin of pattern and polarity in the Drosophila embryo
271. Neural correlates of perceptual motion coherence
272. Transparency and coherence in human motion perception
273. Muscular dystrophies and the dystrophin-glycoprotein complex
274. Apoliprotein E and Alzheimer's disease
275. Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex
276. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
277. A model for the formation of ocular dominance stripes
278. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer
279. Cadherins: A molecular family important in selective cell-cell adhesion
280. Cadherins in brain patterning and neural network formation
281. On the permeability of the end-plate membrane during the action of transmitter
282. Physiological studies on neural mechanisms of visual localization and discrimination
283. Diversity and pattern in the developing spinal cord
284. Specification of motor neuron identity by the MNR2 homeodomain protein
285. Genetic enhancement of learning and memory in mice
286. Regeneration of injured axons in the adult mammalian central nervous system
287. First glances: The vision of infants. The Friedenwald Lecture
288. Sequence of probable potassium channels at Shaker locus of Drosophila
289. The molecular biology of axon guidance
290. From grasshopper to Drosophila: A common plan for neuronal development
291. Functional analysis of primary-visual cortex in humans
292. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic palsticity in spatial memory
293. Two cortical visual systems
294. Synchronous activity in the visual system
295. Functional organization of primate visual cortex
296. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variations in fragile X syndrome
297. The correlation theory of brain function
298. Odorant receptors govern the formation of a precise topographic map
299. Triplet repeat expansion mutations: The example of fragile X syndrome
300. Stroop-like effects for monkeys and humans: Processing speed or strength of association?
301. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination
302. Excitatory amino acid transmitters
303. Visual imagery for words: The Hebb test
304. SNAREpins: Minimal machinery for membrane fusion
305. Self-differentiation of the basic patterns of coordination
306. Correlational structure of spontaneous neuronal activity in the developing lateral geniculate nucleus in vivo
307. Single-cell responses in striate cortex of kittens deprived of vision in one eye
308. Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens
309. Positional information and the spatial pattern of cellular differentiation
310. A striking organization of a large family of human neural cadherin-like cell adhesion genes
311. CREB and the formation of long-term memory
312. CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila
313. A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene
314. Importance of AMPA receptors for hipocampal LTP but not for spatial learning
315. Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system