DNA vaccination of mice with a plasmid encoding Puumala hantavirus nucleocapsid protein mimics the B-cell response induced by virus infection

Journal of Biotechnology

Volumn 84, Issue 1, 2000, Pages 73-78

  Koletzki, D ^a,c   Schirmbeck, R ^b   Lundkvist, A ^a,d   Meisel, H ^c   Kruger D H ^c   Ulrich, R ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF ULM   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

Author keywords

Antibody; DNA vaccine; Epitope; Hantavirus; Nucleocapsid protein; Puumala virus

Indexed keywords

ANTIBODIES; DNA; ENZYME KINETICS; VACCINES; VIRUSES;

DNA VACCINES; NUCLEOCAPSID PROTEIN;

IMMUNOLOGY;

ANTIBODY; CAPSID PROTEIN; DNA VACCINE; EPITOPE;

ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; HUMORAL IMMUNITY; MOLECULAR CLONING; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PUUMALA VIRUS; VACCINATION; VIRUS INFECTION; VIRUS NUCLEOCAPSID;

ANIMAL; ANTIBODIES, VIRAL; B-LYMPHOCYTES; EPITOPES; GENE EXPRESSION REGULATION, VIRAL; HANTAVIRUS; HANTAVIRUS INFECTIONS; MICE; MICE, INBRED BALB C; NUCLEOCAPSID PROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); SUPPORT, NON-U.S. GOV'T; VACCINES, DNA;

EID: 0034681031     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(00)00329-1     Document Type: Article

References (18)

1. Bharadwaj M., Lyons C.R., Wortman I.A., Hjelle B. Intramuscular inoculation of Sin Nombre hantavirus cDNAs induces cellular and humoral immune response in BALBc mice. Vaccine. 17:1999;2836-2843.
2. Cifire, F., 1997. Expression und immunologische Charakterisierung des Nukleokapsidproteins vom Hantavirusisolat Vranica. Ph.D. thesis, Free University Berlin, Germany.
3. Davis H.L., McCluskie M.J. DNA vaccines for viral diseases. Microb. Infect. 1:1999;7-21.
4. Davis H.L., Whalen R.G., Demeneix B.A. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Hum. Gene Ther. 4:1993;151-159.
5. Elgh F., Lundkvist Å., Alexeyev O.A., Wadell G., Juto P. A major antigenic domain for the human humoral response to Puumala virus nucleocapsid protein is located at the amino-terminus. J. Virol. Methods. 59:1996;161-172.
6. Giraud A., Ataman-Onal Y., Battail N., Piga N., Brand D., Mandrand B., Verrier B. Generation of monoclonal antibodies to native immunodeficiency virus type 1 envelope glycoprotein by immunization of mice with naked RNA. J. Virol. Methods. 79:1999;75-84.
7. Gött P., Zöller L., Darai G., Bautz E.K. A major antigenic domain of hantaviruses is located on the aminoproximal site of the viral nucleocapsid protein. Virus Genes. 14:1997;31-40.
8. Hooper J.W., Kamrud K.I., Elgh F., Custer D., Schmaljohn C.S. DNA vaccination with hantavirus M segments elicits neutralizing antibodies and protects against Seoul virus infection. Virology. 255:1999;269-278.
9. Kanerva M., Mustonen J., Vaheri A. Pathogenesis of Puumala and other hantavirus infections. Rev. Med. Virol. 8:1998;67-86.
10. Koletzki, D., Lundkvist, Å, Brus Sjölander, K., Gelderblom, H.R., Niedrig, M., Meisel, H., Krügrt, D.H., Ulrich, R., 2000. Puumala (PUU) hantavirus strain differences and insertion positions in the hepatitis B virus core antigen influence B-cell immunogenicity and protective potential of core-derived particles. Virology 275, in press.
11. Krasemann S., Jürgens T., Bodemer W. Generation of monoclonal antibodies against prion proteins with an unconventional nucleic acid-based immunization strategy. J. Biotechnol. 73:1999;119-129.
12. Lundkvist Å., Björsten S., Niklasson B., Ahlborg N. Mapping of B-cell determinants in the nucleocapsid protein of Puumala virus: definition of epitopes specific for acute immunoglobulin G recognition in humans. Clin. Diagn. Lab. Immunol. 2:1995;82-86.
13. Lundkvist Å., Kallio-Kokko H., Brus Sjölander K., Lankinen H., Niklasson B., Vaheri A., Vapalahti O. Characterization of Puumala virus nucleocapsid protein: identification of B-cell epitopes and domains involved in protective immunity. Virology. 216:1996;397-406.
14. Reip A., Haring B., Sibold C., Stohwasser R., Bautz E.K.F., Darai G., Meisel H., Krüger D.H. Coding strategy of the S and M genomic segments of a hantavirus representing a new subtype of the Puumala serotype. Arch. Virol. 140:1995;2011-2026.
15. Schmaljohn C.S., Chu Y.K., Schmaljohn A.L., Dalrymple J.M. Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants. J. Virol. 64:1990;3162-3170.
16. Ulmer J.B., Donelly J.J., Parker S.E. Heterologous protection against influenza by injection of DNA encoding viral protein. Science. 259:1993;1745-1749.
17. Ulrich R., Lundkvist Å., Meisel H., Koletzki D., Brus Sjölander K., Gelderblom H.R., Borisova G., Schnitzler P., Darai G., Krüger D.H. Chimeric HBV core particles carrying a defined segment of Puumala hantavirus nucleocapsid protein evoke protective immunity in an animal model. Vaccine. 16:1998;272-280.
18. Vapalahti O., Kallio-Kokko H., Närnänen A., Julkunen I., Lundkvist Å., Plyusnin A., Lehväslaiho H., Brummer-Korvenkontio M., Vaheri A., Lankinen H. Human B-cell epitopes of Puumala virus nucleocapsid protein, the major antigen in early serological response. J. Med. Virol. 46:1995;293-303.