Loreclezole as a simple functional marker for homomeric ρ type GABA(C) receptors

European Journal of Pharmacology

Volumn 408, Issue 2, 2000, Pages

  Thomet, Urs ^a   Baur, Roland ^a   Dodd, Robert H ^b   Sigel, Erwin ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b CNRS   (France)

Author keywords

1 subunit; GABA ( aminobutyric acid); GABA(C) receptor; Loreclezole

Indexed keywords

1 (2,3,4,5 TETRAHYDRO 5 OXO 2 FURYL) 2 N (4 TOLUENESULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 4 AMINOBUTYRIC ACID C RECEPTOR; BIOCHEMICAL MARKER; LORECLEZOLE; PENTOBARBITAL; RECEPTOR SUBUNIT; ROD 188; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; IC 50; ION CURRENT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

ANIMALS; ANTICONVULSANTS; GAMMA-AMINOBUTYRIC ACID; MEMBRANE POTENTIALS; RECEPTORS, GABA; RECEPTORS, GABA-B; TRIAZOLES; XENOPUS;

EID: 0034680827     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00778-0     Document Type: Article

References (7)

1. A single amino acid confers barbiturate sensitivity upon the GABA ρ1 receptor
2. Cloning of the gamma-aminobutyric acid (GABA) ρ1 cDNA: A GABA receptor subunit highly expressed in the retina
3. 5-[ 1'-(2'-N-Arylsulfonyl-1',2',3',4'-tetrahydroisoquinolyl)]-4,5-dih ydro-2(3H)-furanones: Positive allosteric modulators of the GABA(A) receptor with a new mode of action
4. Gamma-Aminobutyric acid A or C receptor? Gamma-Aminobutyric acid ρ1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive gamma-aminobutyric acid responses in Xenopus oocytes
5. The effect of subunit composition of rat brain GABA(A) receptors on channel function
6. A novel positive allosteric modulator of the GABA(A) receptor: The action of (+)-ROD188
7. The modulatory action of loreclezole at the γ-aminobutyric acid type A receptor is determined by a single amino acid in the β2 and β3 subunit