The design and synthesis of thrombin inhibitors: The introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 14, 2000, Pages 1567-1570

  Hayler, Judy ^a   Kane, Peter D ^a   LeGrand, Darren ^a   Lugrin, Florence ^a   Menear, Keith ^a   Price, Richard ^a   Allen, Mark ^a   Cockcroft, Xiaoling ^a   Ambler, John ^a   Butler, Keith ^a   Dunnet, Karren ^a   Mitchelson, Andrew ^a   Talbot, Mark ^a   Tweed, Morris ^a   Wills, Nicholas ^a  

^a NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; CGH 1484; CGH 752; QUINOLINE DERIVATIVE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA THROMBOSIS; ARTICLE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG INHIBITION; DRUG SYNTHESIS; IN VIVO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ALANINE; ANIMALS; ANTITHROMBINS; BIOLOGICAL AVAILABILITY; CHYMOTRYPSIN; DRUG DESIGN; KINETICS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PARTIAL THROMBOPLASTIN TIME; PLASMIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIAZOLES; THROMBOSIS; TRYPSIN;

EID: 0034679838     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00283-3     Document Type: Article

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