Effects of differential modulation of μ-, δ- and κ-opioid systems on bicuculline-induced convulsions in the mouse

Brain Research

Volumn 862, Issue 1-2, 2000, Pages 120-126

  Yajima, Yoshinori ^a   Narita, Minoru ^a,b   Takahashi Nakano, Yuki ^a   Misawa, Miwa ^a   Nagase, Hiroshi ^b,c   Mizoguchi, Hirokazu ^b   Tseng, Leon F ^b   Suzuki, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c TORAY INDUSTRIES INC   (Japan)

Author keywords

Bicuculline; Convulsions; GABA(A) receptors; Mice; Opiates; Opioid receptors; Synaptic transmission

Indexed keywords

1,2,3,4,4A,5,12,12AALPHA OCTAHYDRO 4AALPHA (3 HYDROXYPHENYL) 2 METHYLQUINOLINO[2,3 G]ISOQUINOLINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; 4 AMINOBUTYRIC ACID A RECEPTOR; BETA FUNALTREXAMINE; BICUCULLINE; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; MORPHINE; MU OPIATE RECEPTOR AGONIST; NALTRINDOLE; OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CONVULSION; DRUG EFFECT; GABAERGIC TRANSMISSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANIMALS; BICUCULLINE; BRAIN CHEMISTRY; CONVULSANTS; ENKEPHALIN, D-PENICILLAMINE (2,5)-; EPILEPSY, TONIC-CLONIC; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; QUINOLINES; RECEPTORS, GABA-A; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SEIZURES; SYNAPTIC TRANSMISSION;

EID: 0034678524     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02096-5     Document Type: Article

References (22)

1. Di Chiara G., North R.A. Neurobiology of opiate abuse. Trends Pharmacol. Sci. 13:1992;185-193.
2. Foot F., Gale K. Morphine potentiates seizures induced by GABA antagonist and attenuates seizures induced by electroshock in the rat. Eur. J. Pharmacol. 95:1983;259-264.
3. Frenk H. Pro- and anticonvulsant actions of morphine and the endogenous opioids: involvement and interactions of multiple opiate and non-opiate systems. Brain Res. 287:1983;197-210.
4. Funada M., Suzuki T., Narita M., Misawa M., Nagase H. Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice. Brain Res. 619:1993;163-172.
5. Haley T.J., McCormick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. 12:1957;12-15.
6. Iwamoto E.T. Locomotor activity and antinociception after putative mu, kappa and sigma opioid receptor agonists in the rat: influence of dopaminergic agonists and antagonists. J. Pharmacol. Exp. Ther. 217:1981;451-460.
7. Jackson H.C., Nutt D.J. Investigation of the involvement of opioid receptors in the action of anticonvulsants. Psychopharmacology. 111:1993;486-490.
8. MacDonaldo R.L., Werz M.A. Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones. J. Physiol. 377:1986;237-249.
9. 2]deltorphin II-induced locomotor hyperactivity. Life Sci. 59:1996;PL69-73.
10. Narita M., Takahashi Y., Suzuki T., Misawa M., Nagase H. An ATP-sensitive potassium channel blocker abolishes the potentiating effect of morphine on the bicuculline-induced convulsion in mice. Psychopharmacology. 110:1993;500-502.
11. Piredda S., Lim C.R., Gale K. Intracerebral site of convulsant action of bicuculline. Life Sci. 36:1985;1295-1298.
12. Reisine T. Opiate receptors. Neuropharmacology. 34:1995;463-472.
13. Snead O.C., Simonato M. Opioid peptides and seizures. Fisher R.S., Coyle J.T. Neurotransmitters and Epilepsy. 1991;181-200 Wiley, New York.
14. Spanagel R., Herz A., Shippenberg T.S. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc. Natl. Acad. Sci. USA. 89:1992;2046-2050.
15. A receptors in seizures of adult rats. Brain Res. 480:1989;378-382.
16. Tallarida R.J., Murray R.B. Manual of Pharmacological Calculations with Computer Programs. 2nd Edition :1987;Springer, New York.
17. Tortella F.C., Robles L., Holaday J.W. U50,488 a highly selective kappa opioid: anticonvulsant profile in rats. J. Pharmacol. Exp. Ther. 237:1986;49-53.
18. Tortella F.C., Echevarria E., Lipkowski A.W., Takemori A.E., Portoghese P.S., Holaday J.W. Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model. Life Sci. 44:1989;661-665.
19. Vaughan C.W., Ingram S.L., Connor M.A., Christie M.J. How opioids inhibit GABA-mediated neurotransmission. Nature. 390:1997;611-614.
20. Vonvoigtlander P.F., Lahti R.A., Ludens J.H. U-50,488: a selective and structurally novel non-mu (kappa) opioid agonist. J. Pharmacol. Exp. Ther. 224:1983;7-12.
21. Werz M.A., Macdonald R.L. Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration. J. Pharmacol. Exp. Ther. 234:1985;49-56.
22. Werz M.A., Macdonald R.L. Dynorphin reduces voltage-dependent calcium conductance of mouse dorsal root ganglion neurons. Neuropeptides. 5:1984;253-256.