The pontine micturition center in rat receives direct lumbosacral input. An ultrastructural study

Neuroscience Letters

Volumn 282, Issue 1-2, 2000, Pages 29-32

  Blok, Bertil F M ^a   Holstege, G ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Barrington's area; Electron microscopy; External urethral sphincter; Spinal cord; Urinary bladder; Voiding; Wheat germ agglutinin horseradish peroxidase

Indexed keywords

WHEAT GERM AGGLUTININ HORSERADISH PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER SPHINCTER; ELECTRON MICROSCOPY; LUMBOSACRAL SPINE; MALE; MICTURITION; MICTURITION REFLEX; NONHUMAN; PRIORITY JOURNAL; RAT; SACRAL SPINAL CORD; TEGMENTUM; ULTRASTRUCTURE;

ANIMALS; MALE; MICROSCOPY, ELECTRON; NEURAL PATHWAYS; PONS; RATS; SPINAL CORD; SYNAPSES; URINATION; WHEAT GERM AGGLUTININ-HORSERADISH PEROXIDASE CONJUGATE;

EID: 0034677854     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)00833-8     Document Type: Article

References (19)

1. Athwal B.S., Berkley K.J., Brennan A., Craggs M., Fowler C.J., Hussain I., Sakakibara R., Frackowiak R.S.J. Bladder volume-related activity in human brain. J. Physiol. 518:1999;169.
2. Blok B.F.M., Holstege G. Direct projections from the periaqueductal gray to the pontine micturition center (M-region) An anterograde and retrograde tracing study in the cat. Neurosci. Lett. 166:1994;93-96.
3. Blok B.F.M., Holstege G. Ultrastructural evidence for a direct pathway from the pontine micturition center to the parasympathetic preganglionic motoneurons of the bladder of the cat. Neurosci. Lett. 222:1997;195-198.
4. Blok B.F.M., De Weerd H., Holstege G. Ultrastructural evidence for a paucity of projections from the lumbosacral cord to the pontine micturition center or M-region in the cat: a new concept for the organization of the micturition reflex with the periaqueductal gray as central relay. J. Comp. Neurol. 359:1995;300-309.
5. Blok B.F.M., De Weerd H., Holstege G. The pontine micturition center projects to sacral cord GABA immunoreactive neurons in the cat. Neurosci. Lett. 233:1997;109-112.
6. Blok B.F.M., Sturms L.M., Holstege G. Brain activation during micturition in humans. Brain. 121:1998;2033-2042.
7. Blok B.F.M., Van Maarseveen J.T.P.W., Holstege G. Electrical stimulation of the sacral dorsal gray commissure evokes relaxation of the external urethral sphincter in the cat. Neurosci. Lett. 249:1998;68-70.
8. Blok B.F.M., Willemsen A.T.M., Holstege G. A PET study on the brain control of micturition in humans. Brain. 120:1997;111-121.
9. De Groat W.C., Nadelhaft I., Milne R.J., Booth A.M., Morgan C., Thor K. Organization of the sacral parasympathetic reflex pathways to the urinary bladder and lar ge intestine. J. Auto. Nerv. Syst. 3:1981;135-160.
10. Ding Y.Q., Zheng H.X., Gong L.W., Lu Y., Zhao H., Qin B.Z. Direct projections from the lumbosacral spinal cord to Barrington's nucleus in the rat: a special reference to micturition reflex. J. Comp. Neurol. 389:1997;149-160.
11. Hamilton M.O., Papka R.E., O'Donoghue D.L., Vaidya A.M., Williams S.J., Poff C.R., McNeill D.L. Spinal projection neurons to the laterodorsal pontine tegmental nucleus: relationship to preganglionic neurons and nitric oxide synthase. J. Comp. Neurol. 353:1997;1-8.
12. Hancock M.B., Peveto C.A. Preganglionic neurons in the sacral spinal cord of the rat: an HRP study. Neurosci. Lett. 11:1979;1-5.
13. Holstege G., Kuypers H.G.J.M., Boer R.C. Anatomical evidence for direct brain stem projections to the somatic motoneuronal cell groups and autonomic preganglionic cell groups in cat spinal cord. Brain Res. 171:1979;229-233.
14. Holstege G., Griffiths D., De Wall H., Dalm E. Anatomical and physiological observations on supraspinal control of bladder and urethral sphincter muscles in the cat. J. Comp. Neurol. 250:1986;449-461.
15. Loewy A.D., Saper C.B., Baker R.P. Descending projections from the pontine micturition center. Brain Res. 172:1979;533-539.
16. Nadelhaft I., Booth A.M. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J. Comp. Neurol. 226:1984;238-245.
17. Noto H., Roppolo J.R., Steers W.D., de Groat W.C. Excitatory and inhibitory influences on bladder activity elicited by electrical stimulation in the pontine micturition center in the rat. Brain Res. 492:1989;99-115.
18. Peschanski M., Ralston H.J. Light and electron microscopic evidence of transneuronal labeling with WGA-HRP to trace somatosensory pathways to the thalamus. J. Comp. Neurol. 236:1985;29-41.
19. Schrøder H.D. Organization of the motoneurons innervating the pelvic muscles of the male rat. J. Comp. Neurol. 192:1980;567-587.