Conformational modulation of human cytochrome P450 2E1 by ethanol and other substrates: A CO flash photolysis study

Biochemistry

Volumn 39, Issue 19, 2000, Pages 5731-5737

  Smith, Stanley V ^b   Koley, Aditya P ^b   Dai, Renke ^b   Robinson, Richard C ^b   Leong, Hoyee ^b   Markowitz, Allen ^a   Friedman, Fred K ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CARBON MONOXIDE; DIMETHYLNITROSAMINE DEMETHYLASE;

ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; HUMAN; MOLECULAR MODEL; PHOTOLYSIS; PHOTOSENSITIVITY; PRIORITY JOURNAL;

ARACHIDONIC ACID; BINDING SITES; CARBON MONOXIDE; CYTOCHROME P-450 CYP2E1; ETHANOL; HALOTHANE; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; PHOTOLYSIS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 0034673982     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000129l     Document Type: Article

References (39)

1. Lu, A. Y., and West, S. B. (1979) Pharmacol. Rev. 31, 277-295.
2. Ryan, D. E., and Levin, W. (1990) Pharmacol. Ther. 45, 153-239.
3. Ortiz de Montellano, P. (1995) Cytochrome P450 Structure, Mechanism, and Biochemistry, Plenum Press, New York.
4. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C., and Nebert, D. W. (1996) Pharmacogenetics 6, 1-42.
5. Ioannides, C. (1996) Cytochromes P450: Metabolic and Toxicological Aspects, CRC Press, Boca Raton, FL.
6. Gibson, G. G., Cinti, D. L., Sligar, S. G., and Schenkman, J. B. (1980) J. Biol. Chem. 255, 1867-1873.
7. Omata, Y., and Friedman, F. K. (1991) Biochem. Pharmacol. 42, 97-101.
8. Koley, A. P., Buters, J. T., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1995) J. Biol. Chem. 270, 5014-5018.
9. Koley, A. P., Buters, J. T. M., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1997) J. Biol. Chem. 272, 3149-3152.
10. Koley, A. P., Buters, J. T. M., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1996) Arch. Biochem. Biophys. 336, 261-267.
11. Koley, A. P., Dai, R., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1997) Biochemistry 36, 3237-3241.
12. Koley, A. P., Robinson, R. C., and Friedman, F. K. (1996) Biochimie 78, 706-713.
13. Koley, A. P., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1997) Biochem. Pharmacol. 53, 455-460.
14. Koley, A. P., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1995) Biochemistry 34, 1942-1947.
15. Koley, A. P., Robinson, R. C., Markowitz, A., and Friedman, F. K. (1994) Biochemistry 33, 2484-2489.
16. Fraser, A. G. (1997) Clin. Pharmacokinet. 33, 79-90.
17. Goasduff, T., and Cederbaum, A. I. (1999) Arch. Biochem. Biophys. 370, 258-270.
18. Lieber, C. S. (1997) Clin. Chim. Acta 257, 59-84.
19. Song, B. J. (1996) Alcohol.: Clin. Exp. Res. 20, 138A-146A.
20. Ronis, M. J., Lindros, K. O., and Ingelman-Sundberg, M. (1996) in Cytochromes P450: Metabolic and Toxicological Aspects (Ioannides, C., Ed.) pp 211-239, CRC Press, Boca Raton, FL.
21. Lee, S. S., Buters, J. T., Pineau, T., Fernandez-Salguero, P., and Gonzalez, F. J. (1996) J. Biol. Chem. 271, 12063-12067.
22. Laethem, R. M., Balazy, M., Falck, J. R., Laethem, C. L., and Koop, D. R. (1993) J. Biol. Chem. 268, 12912-12918.
23. Bell, L. C., and Guengerich, F. P. (1997) J. Biol. Chem. 272, 29643-29651.
24. Zhukov, A., and Ingelman-Sundberg, M. (1997) Eur. J. Biochem. 247, 37-43.
25. Grogan, J., Shou, M., Andrusiak, E. A., Tamura, S., Buters, J. T., Gonzalez, F. J., and Korzekwa, K. R. (1995) Biochem. Pharmacol. 50, 1509-1515.
26. Omura, T., and Sato, R. (1964) J. Biol. Chem. 239, 2379-2385.
27. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985) Anal. Biochem. 150, 76-85.
28. Leach, S. J., and Scheraga, H. A. (1960) J. Am. Chem. Soc. 82, 4790-4792.
29. Markowitz, A., Robinson, R. C., Omata, Y., and Friedman, F. K. (1992) Anal. Instrum. (N.Y.) 20, 213-221.
30. Ravichandran, K. G., Boddupalli, S. S., Hasermann, C. A., Peterson, J. A., and Deisenhofer, J. (1993) Science 261, 731-736.
31. Dai, R., Pincus, M. R., and Friedman, F. K. (1998) J. Protein Chem. 17, 121-129.
32. Dai, R., Zhai, S., Wei, K., Pincus, M. R., Vestal, R. E., and Friedman, F. K. (1998) J. Protein Chem. 17, 643-650.
33. Li, H., and Poulos, T. L. (1997) Nat. Struct. Biol. 4, 140-146.
34. Jefcoate, C. R. (1978) Methods Enzymol. 52, 258-279.
35. Chen, W., Peter, R. M., McArdle, S., Thummel, K. E., Sigle, R. O., and Nelson, S. D. (1996) Arch. Biochem. Biophys. 335, 123-130.
36. Roberts, B. J., Song, B. J., Soh, Y., Park, S. S., and Shoaf, S. E. (1995) J. Biol. Chem. 270, 29632-29635.
37. Fontana, A., Fassina, G., Vita, C., Dalzoppo, D., Zamai, M., and Zambonin, M. (1986) Biochemistry 25, 1847-1851.
38. Wang, M. H., Wade, D., Chen, L., White, S., and Yang, C. S. (1995) Arch. Biochem. Biophys. 317, 299-304.
39. Graham-Lorence, S., Truan, G., Peterson, J. A., Falk, J. R., Wei, S., Helvig, C., and Capdevila, J. H. (1997) J. Biol. Chem. 272, 1127-1135.