Combinatorial chemistry defines general properties of linkers for the optimal display of peptide ligands for binding soluble protein targets to TentaGel microscopic beads

Biochemical and Biophysical Research Communications

Volumn 269, Issue 2, 2000, Pages 591-595

  Thorpe, David S ^a   Walle, Stefan ^a  

^a Selectide Corporation   (United States)

Author keywords

Affinity chromatography; Combinatorial chemistry; Ligand; Linkers; Peptide; Protein; Protein interaction; Receptor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; CALPAIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; STREPTAVIDIN; THROMBIN;

AFFINITY CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; ION EXCHANGE; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

EID: 0034673579     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2323     Document Type: Article

References (3)

1. Lam K. S., Salmon S. E., Hersh E. M., Hruby V. J., Kazmierski W. M., Knapp R. J. A new type of synthetic peptide library for identifying ligand-binding activity. Nature. 358:1991;82-84.
2. Ostrem J. A., al-Obeidi F., Safar P., Safarova A., Stringer S. K., Patek M., LoCascio J. C., Kasireddy P., Thorpe D. S., Sepetov N., Lebl M., Wildgoose P., Strop P. Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry. Biochemistry. 37:1998;1053-1059.
3. Thorpe D. S., Yeoman H., Chan A. W. E., Krchnak V., Lebl M., Felder S. Combinatorial chemistry reveals a new motif that binds the platelet fibrinogen receptor, gpIIbIIIa. Biochem. Biophys. Res. Commun. 256:1999;537-541.