Studies on the preparation and stability of samarium-153 propylene diamine tetramethylene phosphonate (PDTMP) complex as a bone seeker

Applied Radiation and Isotopes

Volumn 53, Issue 6, 2000, Pages 987-991

  Majali, M A ^a   Mathakar, A R ^a   Shimpi, H H ^a   Banerjee, Sharmila ^a   Samuel, Grace ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Bone seeker; Samarium 153; Tetraphosphonates

Indexed keywords

BONE; COMPLEXATION; ORGANOMETALLICS; PHOSPHORUS COMPOUNDS; RADIATION CHEMISTRY; SAMARIUM COMPOUNDS; SYNTHESIS (CHEMICAL);

BIODISTRIBUTION; LIGANDS; PROPYLENE DIAMINE TETRAMETHYLENE PHOSPHONATE;

RADIOISOTOPES;

LIGAND; PHOSPHONIC ACID DERIVATIVE; SAMARIUM 153;

ANIMAL EXPERIMENT; ARTICLE; BONE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG STABILITY; ELECTROPHORESIS; MALE; NONHUMAN; PAPER CHROMATOGRAPHY; PRIORITY JOURNAL; RAT;

ANIMALS; BONE AND BONES; DIPHOSPHONATES; DRUG STABILITY; HUMANS; LIVER; MALE; ORGANOMETALLIC COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; SAMARIUM; TISSUE DISTRIBUTION;

EID: 0034672937     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(99)00270-5     Document Type: Article

References (11)

1. Atkins H.L. Overview of Nuclides for bone pain palliation. Appl. Radiat. Isot. 49:1998;277.
2. Banerjee, S., et al., 1999. Synthesis,characterization and radiochemical studies of some phosphonate ligands. communicated.
3. 153Sm chelates: potential therapeutic agents. J. Nucl. Med. 28:1987;495.
4. 153Sm EDTMP for pain relief in malignant bone and joint diseases. Eur. J. Nucl. Med. 25:1998;S13.
5. Knapp F.F. Jr, et al. Reactor produced radioisotopes from ORNL for bone pain palliation. Appl. Radiat. Isot. 49:1998;309.
6. Lewington V.J. Targeted nuclear therapy for bone metastases. Eur. J. Nucl. Med. 20:1993;66.
7. 153Sm -EDTMP. J. Nucl. Med. 28:1987;505.
8. Moedritzer K., Irani R.R. Direct synthesis of α-amino methyl phosphonic acid: Mannich type reactions with o-phosphorous acid. J. Org. Chem. 31:1966;1603.
9. Noronha O.P.D, et al. Unpublished observations.
10. 153Sm -chelates: Potential therapeutic radiopharmaceuticals for the treatment of cancer in bone. IJNM. 8:1993;12.
11. Winston M.A. Radioisotope therapy in bone and joint diseases. Sem. Nucl. Med. 9:1979;114.