Continuous flow displacement immunosensors: A computational study

Analytical Biochemistry

Volumn 287, Issue 2, 2000, Pages 234-242

  Holt, David B ^a   Kusterbeck, Anne W ^a   Ligler, Frances S ^a  

^a NAVAL RESEARCH LABORATORY   (United States)

Author keywords

Biosensor; Computational modeling; Displacement immunoassay

Indexed keywords

ANTIBODIES; BINDING SITES; BIOASSAY; BIOSENSORS; POROUS MATERIALS;

ANTIBODY BINDING SITES; COMPUTATIONAL MODEL; COMPUTATIONAL STUDIES; CONTINUOUS FLOWS; DISPLACEMENT IMMUNOASSAYS; DISPLACEMENT SENSOR; HIGH SURFACE AREA; SENSOR PERFORMANCE;

IMMUNOSENSORS;

ANTIBODY;

ANTIGEN BINDING; ARTICLE; BINDING SITE; BIOSENSOR; CONTINUOUS FLOW DISPLACEMENT IMMUNOSENSOR; IMMUNOASSAY; IMMUNOSENSOR; MATHEMATICAL MODEL; PRIORITY JOURNAL; SIMULATION; VALIDATION PROCESS;

EID: 0034672397     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2000.4856     Document Type: Article

References (31)

1. Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance: Use of nonlinear least squares analysis methods
2. Interpretation of deviations from pseudo-first-order kinetic behavior in the characterization of ligand binding by biosensor technology
3. Studies of protein interactions by biosensor technology: An alternative approach to the analysis of sensorgrams deviating from pseudo-first-order kinetic behavior
4. Theoretical and experimental considerations of the pseudo-first-order approximation in conventional kinetic analysis of IAsys biosensor data
5. Determination of binding constants by equilibrium titration with circulating sample in a surface plasmon resonance biosensor
6. Potential of biosensor technology for the characterization of interactions by affinity chromatography
7. Second-order kinetic analysis of IAsys biosensor data: Its use and applicability
8. Extending the range of rate constants available from BIACORE: Interpreting mass transport-influenced binding data
9. Survey of the 1998 biosensor literature
10. Application of a portable immunosensor to detect the explosives TNT and RDX in groundwater samples
11. A displacement flow immunosensor for explosive detection using microcapillaries
12. Analysis of cortisol with a flow displacement immunoassay
13. Competitive flow injection enzyme immunoassay for steroids using a post-column reaction technique
14. Detection of cocaine using the flow immunosensor
15. Kinetics of antibody binding at solid - Liquid interfaces in flow
16. Low-molecular-weight displacers for high-resolution protein separations
17. A continuous flow immunoassay for rapid and sensitive detection of small molecules
18. A membrane-based displacement flow immunoassay
19. Capillary-based displacement flow immunosensor
20. Physics of the granular state
21. A computational reaction-diffusion model for the analysis of transport-limited kinetics
22. Kinetics of antigen-antibody reactions at solid - Liquid interfaces
23. Effect of antibody density on the displacement kinetics of a flow immunoassay
24. Theory of heterogeneity in displacement reactions
25. An analysis of analyte-receptor binding kinetics for biosensor applications: Influence of the fractal dimension on the binding rate coefficient
26. Continuous-flow immunosensor for detection of explosives
27. Use of thiol-terminal silanes and heterobifunctional crosslinkers for immobilization of antibodies on silica surfaces