The SP1 sites of the human apoCIII enhancer are essential for the expression of the apoCIII gene and contribute to the hepatic and intestinal expression of the apoA-I gene in transgenic mice

Nucleic Acids Research

Volumn 28, Issue 24, 2000, Pages 4919-4929

  Georgopoulos, Spiros ^a   Kan, Horng Yuan ^a   Reardon Alulis, Catherine ^b   Zannis, Vassilis ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN C3; CHLORAMPHENICOL ACETYLTRANSFERASE; MESSENGER RNA; TRANSCRIPTION FACTOR SP1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; ENZYME ACTIVITY; FEMALE; GENE CLUSTER; GENE EXPRESSION; GENE MUTATION; HEART; HUMAN; IN VIVO STUDY; INTESTINE; KIDNEY; LIVER; LUNG; MALE; MESSENGER RNA SYNTHESIS; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SPLEEN; STOMACH; TRANSGENE; TRANSGENIC MOUSE;

ANIMALIA; FELIS CATUS; MUS MUSCULUS;

EID: 0034672101     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/28.24.4919     Document Type: Article

References (38)

1. Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. Synergism between hepatic nuclear factor-4 molecules bound to promoter and distal enhancer sites
2. Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene
3. Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors
4. Binding specificity and modulation of the human ApoCIII promoter activity by heterodimers of ligand-dependent nuclear receptors
5. Transcriptional regulation of human apolipoprotein genes apoB, apoCIII and apoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2 and EAR-3
6. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells
7. Complex interactions between SP1 bound to multiple distal regulatory sites and HNF-4 bound to the proximal promoter lead to transcriptional activation of liver-specific human APOCIII gene
8. Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene
9. Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4
10. Characterization of an enhancer element in the human apolipoprotein C-III gene that regulates human apolipoprotein A-I gene expression in the intestinal epithelium
11. Tissue-specific expression of the human apolipoprotein A-IV gene in transgenic mice
12. Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3′ to the gene in the promoter of the adjacent convergently transcribed apoC-III gene
13. A hormone response element in the human apolipoprotein CIII (ApoCIII) enhancer is essential for intestinal expression of the apoA-I and apoCIII gene and contributes to the hepatic expression of the two linked genes in transgenic mice
14. Alterations of the glutamine residues of human apolipoprotein AI propeptide by in vitro mutagenesis. Characterization of the normal and mutant protein forms
15. Isolation and characterization of the human apolipoprotein A-I gene
16. The - 700/-310 fragment of the apolipoprotein A-IV gene combined with the -890/-500 apolipoprotein C-III enhancer is sufficient to direct a pattern of gene expression similar to that for the endogenous apolipoprotein A-IV gene
17. Ultraviolet mapping of the adenovirus 2 early promoters
18. Comparison of three actin-coding sequences in the mouse; evolutionary relationships between the actin genes of warm-blooded vertebrates
19. An improved CAT assay for promoter analysis in either transgenic mice or tissue culture cells
20. Distribution of apolipoprotein A-I, C-III and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages
21. Apolipoprotein gene expression in the rabbit: Abundance, size and distribution of apolipoprotein mRNA species in different tissues
22. Linkage, evolution and expression of the rat apolipoprotein A-I, C-III and A-IV genes
23. Apolipoprotein multigene family: Tandem organization of human apolipoprotein AI, CIII and AIV genes
24. A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways
25. Binding specificity and modulation of the apoA-I promoter activity by homo-and heterodimers of nuclear receptors
26. Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites
27. Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.E
28. High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3
29. Direct physical interactions between SP1 and HNF-4 mediates synergistic transactivation of the apolipoprotein CIII promoter
30. HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study
31. Longevity syndromes: Familial hypoβ and familial hyperα lipoproteinemia
32. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI
33. Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein
34. Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat
35. The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat
36. Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice