Cloning and functional expression of rKCNQ2 K+ channel from rat brain

Molecular Brain Research

Volumn 80, Issue 2, 2000, Pages 269-278

  Jow, Flora ^a   Wang, Ke Wei ^a  

^a PFIZER INC   (United States)

Author keywords

Epilepsy; Genistein; KCNQ2; Oocyte; Potassium channel; Tyrosine phosphorylation; Voltage clamp

Indexed keywords

POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BRAIN; DNA LIBRARY; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; OOCYTE; OPEN READING FRAME; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; VOLTAGE CLAMP; XENOPUS;

ANIMALS; BENZOQUINONES; BRAIN CHEMISTRY; CELLS, CULTURED; CLONING, MOLECULAR; ENZYME INHIBITORS; EPILEPSY; GENE EXPRESSION; GENISTEIN; HUMANS; KCNQ2 POTASSIUM CHANNEL; KIDNEY; LACTAMS, MACROCYCLIC; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; OOCYTES; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN-TYROSINE KINASES; QUINONES; RATS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TETRAETHYLAMMONIUM; TYROSINE; XENOPUS;

ANIMALIA; RODENTIA;

EID: 0034665829     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00146-7     Document Type: Article

References (26)

1. Biervert C., Schroeder B.C., Kubisch C., et al. A potassium channel mutation in neonatal human epilepsy. Science. 279:1998;403-406.
2. Singh N.A., Charlier C., Stauffer D., et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat. Genet. 18:1998;25-29.
3. Charlier C., Singh N.A., Ryan S.G., et al. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat. Genet. 18:1998;53-55.
4. Wei A., Jegla T., Salkoff L. Eight potassium channel families revealed by the C. elegans genome project. Neuropharmacology. 35:1996;805-829.
5. Wang Q., Curran M.E., Splawski I., et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet. 12:1996;17-23.
6. Neyroud N., Tesson F., Denjoy I., et al. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat. Genet. 15:1997;186-189.
7. Kubisch C., Schroeder B.C., Friedrich T., et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell. 96:1999;437-446.
8. Wang H.S., Pan Z., Shi W., et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 282:1998;1890-1893.
9. Selyanko A.A., Hadley J.K., Wood I.C., et al. Two types of K+ channel subunit, erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J. Neurosci. 19:1999;7742-7756.
10. Stoffel M., Jan L.Y. Epilepsy genes: excitement traced to potassium channels. Nat. Genet. 18:1998;6-8.
11. Wang K.W., Goldstein S.A. Subunit composition of minK potassium channels. Neuron. 14:1995;1303-1309.
12. Nakamura M., Watanabe H., Kubo Y., et al. KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels. Receptors Channels. 5:1998;255-271.
13. Schroeder B.C., Kubisch C., Stein V., Jentsch T.J. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature. 396:1998;687-690.
14. Jan L.Y., Jan Y.N. Potassium channels and their evolving gates. Nature. 371:1994;119-122.
15. MacKinnon R. Pore loops: an emerging theme in ion channel structure. Neuron. 14:1995;889-892.
16. Yang W.P., Levesque P.C., Little W.A., et al. Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy. J. Biol. Chem. 273:1998;19419-19423.
17. Jonas E.A., Kaczmarek L.K. Regulation of potassium channels by protein kinases. Curr. Opin. Neurobiol. 6:1996;318-323.
18. Fadool D.A., Levitan I.B. Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation. J. Neurosci. 18:1998;6126-6137.
19. Sobko A., Peretz A., Attali B. Constitutive activation of delayed-rectifier potassium channels by a src family tyrosine kinase in Schwann cells. EMBO J. 17:1998;4723-4734.
20. Wang Q. Regulation of a human neuronal voltage-gated potassium channel (hKv1.1) by protein tyrosine phosphorylation and dephosphorylation. Ann. NY Acad. Sci. 868:1999;447-479.
21. F. Jow, K.W. Wang, Modulation of KCNQ2 K+ channels by protein kinases. 29th Annual Neuroscience Meeting, Miami Beach, (1999) abstract: 686.15.
22. E.C. Conley, W.J. Brammar, The Ion Channel Factsbook IV: Voltage-Gated Channels, Academic Press, London, 1999, pp. 457-460.
23. Washizuka T., Horie M., Obayashi K., Sasayama S. Genistein inhibits slow component delayed-rectifier K+ currents via a tyrosine kinase-independent pathway. J. Mol. Cell Cardiol. 30:1998;2577-2590.
24. Molokanova E., Savchenko A., Kramer R.H. Noncatalytic inhibition of cyclic nucleotide-gated channels by tyrosine kinase induced by genistein. J, Gen. Physiol. 113:1999;45-56.
25. Abitbol I., Oeretz A., Lerche C., Busch A.E., Attali B. Stilbenes and fenamates rescure the loss of Iks channel function induced by an LQT5 mutation and other Isk mutants. EMBO J. 18:1999;4137-4148.
26. Rundfeldt C., Netzer R. The novel anticonvulsant retigabine activates M-current in Chinese hampster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci. Lett. 000:2000;1-4.