Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps

Journal of Molecular Biology

Volumn 302, Issue 2, 2000, Pages 327-338

  Bowers, Jayson ^a   Tran, Phuoc T ^b   Liskay, R Michael ^b   Alani, Eric ^a  

^a Department of Obstetrics Gynecology   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

ATP; Mismatch recognition; MLH1 PMS1; MSH2 MSH6

Indexed keywords

ADENOSINE TRIPHOSPHATASE; FUNGAL DNA; FUNGAL PROTEIN; HYBRID PROTEIN; PROTEIN MIH1; PROTEIN MSH2; PROTEIN MSH6; PROTEIN PMS1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BASE MISPAIRING; BASE PAIRING; BINDING AFFINITY; COMPLEX FORMATION; DNA REPAIR; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN STABILITY; YEAST;

EID: 0034665740     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4081     Document Type: Article

References (53)

1. The Saccharomyces cerevisiae Msh2p and Msh6p form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base-pairs
2. Genetic and biochemical analysis of Msh2p-Msh6p: Role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base-pair recognition
3. MutS mediates heteroduplex loop formation by a translocation mechanism
4. Initiation of methyl-directed mismatch repair
5. Crystal structure and ATPase activity of MutL: Implications for DNA repair and mutagenesis
6. Transformation of MutL by ATP binding and hydrolysis: A switch in DNA mismatch repair
7. Physical interaction between components of DNA mismatch repair and nucleotide excision repair
8. Heteroduplex DNA and ATP induced conformational changes of a MutS mismatch repair protein from Thermus aquaticus
9. DNA-dependent activation of the hMutSalpha ATPase
10. Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism
11. A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition
12. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
13. The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches
14. Multifunctional yeast high-copy-number shuttle vectors
15. Mismatch repair systems in Saccharomyces cerevisiae
16. Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae
17. The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA
18. The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations
19. Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier
20. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
21. hMSH2-hMSH6 forms a hydrolysis-independent sliding damp on mismatched DNA
22. The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
23. Isolation and characterization of the Escherichia coli mutL gene product
24. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
25. Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities
26. Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex
27. ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes
28. The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity
29. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD
30. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
31. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha
32. Mutation in the magnesium binding site of hMSH6 disables the hMutSα sliding clamp from translocating along DNA
33. Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
34. PCNA: Structure, functions and interactions
35. Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins
36. Eukaryotic DNA mismatch repair
37. DNA mismatch correction in a defined system
38. Photocross-linking of the NH2-terminal region of Taq MutS protein to the major groove of a heteroduplex DNA
39. Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA
40. recA protein-catalyzed strand assimilation: Stimulation by Escherichia coli single-stranded DNA-binding protein
41. Mismatch repair in replication fidelity, genetic recombination and cancer biology
42. Seven-base-pair inverted repeats in DNA form stable hairpins in vivo in Saccharomyces cerevisiae
43. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast
44. EXO1 and MSH6 are high copy suppressors of conditional mutations in the MSH2 mismatch repair gene of S. cerevisiae
45. Rapid motions in protein molecules
46. Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair
47. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
48. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
49. Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
50. Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3
51. Dominant negative mutator mutations in the mutS gene of Escherichia coli