Phosphatase inhibition promotes antiapoptotic but not proliferative signaling pathways in erythropoietin-dependent HCD57 cells

Blood

Volumn 96, Issue 6, 2000, Pages 2084-2092

  Lawson, A E ^a   Bao, H ^a   Wickrema, A ^a   Jacobs Helber, S M ^a   Sawyer, S T ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CELL PROTEIN; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; ORTHOVANADIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN BAD; PROTEIN BCL X; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SERINE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TYROSINE; UNCLASSIFIED DRUG; VAV PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0034665670     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.6.2084.h8002084_2084_2092     Document Type: Article

References (50)

1. The molecular mechanism of erythropoietin action
2. Early events in erythropoietin-induced signaling
3. Structure, function, and activation of the erythropoietin receptor
4. The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells - Signals emanating from the erythropoietin receptor
5. Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells
6. Association of JAK2 and STAT5 with erythropoietin receptors: Role of receptor phosphorylation in erythropoietin signal transduction
7. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
8. Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo
9. Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2
10. Erythropoietin induces the tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT1 and STAT5 in erythroid cells
11. Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein
12. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
13. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor
14. Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3
15. Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3
16. Erythropoietin induces the association of phosphatidylinositol 3'-kinase with a tyrosine-phosphorylated protein complex containing the erythropoietin receptor
17. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
18. Friend spleen focus-forming virus induces factor independence in an erythropoietin-dependent erythroleukemia cell line
19. The functional form of the erythropoietin receptor is a 78-kDa protein: Correlation with cell surface expression, endocytosis, and phosphorylation
20. Toxicology of vanadium
21. Protein kinases and phosphatases are involved in erythropoietin-mediated signal transduction
22. Polycythemia vera V. Enhanced proliferation and phosphorylation due to orthovanadate are diminished in polycythemia vera erythroid progenitor cells: A possible defect of phosphatase activity in polycythemia vera
23. Activation of the JAK1-STAT5 pathway by binding of the Friend virus gp55 glycoprotein to the erythropoietin receptor
24. Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes
25. Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2, STAT1, and STAT3
26. Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus
27. AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells
28. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
29. Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei
30. Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver
31. Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization
32. Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2
33. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
34. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
35. jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells
36. Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells)
37. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells
38. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways
39. Jak2 deficiency defines an essendal developmental checkpoint in definitive hematopoiesis
40. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response
41. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation
42. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
43. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
44. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
45. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: A direct role for Stat5 in Bcl-X(L) induction
46. Erythropoietin can induce the expression of bcl-xL through Stat5 in erythropoietin-dependent progenitor cell lines
47. Homodimerization and constitutive activation of the erythropoietin receptor
48. Phosphorylation of erythropoietin receptors in the endoplasmic reticulum by perorthovanadate-mediated inhibition of tyrosine phosphatases
49. JNK and p38 are activated by EPO but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells
50. Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin