Specific binding of sterically stabilized anti-B-cell immunoliposomes and cytotoxicity of entrapped doxorubicin

International Journal of Pharmaceutics

Volumn 205, Issue 1-2, 2000, Pages 101-108

  Lundberg, Bo B ^a   Griffiths, Gary ^b   Hansen, Hans J ^b  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b IMMUNOMEDICS INC   (United States)

Author keywords

Antibody conjugation; B cell lymphoma; Immunoliposome; Liposomal doxorubicin; Monoclonal antibody

Indexed keywords

DOXORUBICIN; DRUG CARRIER; IMMUNOLIPOSOME; IODINE 125; MACROGOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY LL2; PHOSPHATIDYLETHANOLAMINE; UNCLASSIFIED DRUG;

ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CONTROLLED STUDY; DRUG BINDING; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG METABOLISM; DRUG SELECTIVITY; DRUG UPTAKE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INTERNALIZATION; PH; PRIORITY JOURNAL;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BURKITT LYMPHOMA; DOXORUBICIN; DRUG CARRIERS; IMMUNOTOXINS; LIPOSOMES; LYMPHOMA, B-CELL; MICE; TUMOR CELLS, CULTURED;

EID: 0034665270     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00492-0     Document Type: Article

References (22)

1. Blume G., Cevc G., Crommelin M.D., Bakker-Woudenberg L.A., Kluft C., Storm G. Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devises to the ends of the polymeric chains combines effective target binding with long circulation times. Biochim. Biophys. Acta. 1149:1993;180-184.
2. Blume G., Cevc G. Liposomes for sustained drug release in vivo. Biochim. Biophys. Acta. 1029:1990;91-97.
3. Bolotin E.M., Cohen R., Bar L.K., Emanuel S.N., Lasic D.D., Barenholz Y. Ammonium sulfate gradients for efficient and stable remote loading of amphipathic weak bases into liposomes and ligandosomes. J. Liposome Res. 4:1994;455-479.
4. Daleke, D.L., Hong, K., Papahadjopoulos, D., 1990. Endocytosis of liposomes by macrophages: binding, acidification and leakage of liposomes monitored by a new fluoresence assay. Biochim. Biphys. Acta 1024, 352-366.
5. Hansen C.B., Kao G.Y., Moase E.H., Zalipsky S., Allen T.M. Attacment of antibodies to sterically stabilized liposomes: evaluation, camparison and optimization of coupling procedures. Biochim. Biophys. Acta. 1239:1995;133-144.
6. Kirpotin D., Park J.W., Hong K., Zalipsky S., Li W.-L., Carter P., Benz C.C., Papahadjopoulos D. Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cells in vitro. Biochemistry. 36:1997;66-75.
7. Klibanov A.L., Maruyama K., Beckerleg A.M., Torchilin V.P., Huang L. Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation lifetime of liposomes depends on the liposome size and it unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta. 1062:1991;142-148.
8. Lopes de Menezes D.E., Pilarski L.M., Allen T.M. In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma. Cancer Res. 58:1998;3320-3330.
9. Lopes de Menezes D.E., Kierchmeier M.J., Gagne J.-F., Pilarski L.M., Allen T.M. Cellular trafficing and cytoxicity of anti-CD19-targeted liposomal doxorubicin in B lymphoma cells. J. Liposome Res. 9:1999;199-228.
10. Losman M.J., Leung S., Shih L.B., Shevitz J., Shukla R., Haraga L., Goldenberg D.M., Hansen H.J. Development and evaluation of the specificity of a rat monoclonal anti-idiotype antibody, WN, to an anti-B-cell lymphoma monoclonal antibody, LL2. Cancer Res. 55:1995;5978-5982.
11. Lundberg B., Mortimer B.-C., Redgrave T.G. Submicron lipid emulsions containing amphipathic polyethylene glycol for use as drug-carriers with prolonged circulation time. Int. J. Pharm. 134:1996;119-127.
12. Lundberg B.B., Griffiths G., Hansen H.J. Conjugation of an anti-B-cell lymphoma monoclonal antibody, LL2, to long-circulating drug-carrier emulsions. J Pharm. Pharmacol. 51:1999;1055-1099.
13. Maruyama K., Yuda T., Okamoto A., Kojima S., Suginaka A., Iwatsuru M. Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoyl phosphatidylcoline and cholesterol containing amphipathic poly(ethylene glycol). Biochim. Biophys. Acta. 1128:1992;44-49.
14. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
15. Olson F., Hunt C.A., Szoka F.C., Vail W.J., Papahadjopoulos D. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim. Biophys. Acta. 557:1979;9-23.
16. Park J.W., Hong K., Carter P., Asgari H., Guo L.Y., Keller G.A., Wirth C., Shalaby R., Kotts C., Wood W.I., Papahadjopoulos D. Development of anti-p185HER2 immunoliposomes for cancer therapy. Proc. Natl. Acad. Sci. USA. 92:1995;1327-1331.
17. Pawlak-Byczkowska E.J., Hansen H.J., Dion A.S., Goldenberg D.M. Two new monoclonal antibodies EPB-1 and EPB-2, ractive with human lymphoma. Cancer Res. 49:1989;4568-4577.
18. Shih L.B., Lu H.H.-Z., Xuan H., Goldenberg D.M. Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2. Int. J. Cancer. 56:1994;538-545.
19. Stein R., Belisle E., Hansen H., Goldenberg D.M. Epitope specificity of the anti-(B cell lymphoma) monclonal antibody, LL2. Cancer Immunol. Immunother. 37:1993;293-298.
20. Straubinger R.M., Papahadjopoulos D., Hong K. Endocytosis and intracellular fate of liposomes using pyranine as a probe. Biochemistry. 29:1990;4929-4939.
21. Torchilin V.P., Klibanov A.L., Huang L., O'Donnell S., Nossif N.D., Khaw B.A. Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J. 6:1992;2716-2719.
22. Woodle M.C., Lasic D.D. Sterically stabilized liposomes. Bichim. Biophys. Acta. 1113:1992;171-199.