Independent selection by I-A(k) molecules of two epitopes found in tandem in an extended polypeptide antigen

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3206-3213

  Gugasyan, R ^a   Velazquez, C ^a   Vidavsky, I ^a   Deck, B M ^a   Van der Drift, K ^a   Gross, M L ^a   Unanue, E R ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; EPITOPE; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MUTANT PROTEIN; POLYPEPTIDE; PROLINE;

AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY;

EID: 0034665098     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3206     Document Type: Article

References (24)

1. Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-A(k)
2. Appreciating the complexity of MHC class II peptide binding: Lysozyme peptide and I-A(k)
3. Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules
4. Mechanisms and consequences of peptide selection by the I-A(k) class II molecule
5. A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-A(k)
6. Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody
7. Isolation and quantitation of a minor determinant of hen egg white lysozyme bound to I-A(k) by using peptide-specific immunoaffinity
8. Clonal analysis of B- and T-responses to Ia antigens. I. Topology of epitope regions on I-A(k) and I-E(k) molecules analyzed with 35 monoclonal alloantibodies
9. Three-dimensional structure and antigen binding specificity of antibodies
10. Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-A(k) protein
11. Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules
12. 2-terminal including proline as a stop signal for trimming
13. A biological function for the XP motif within the N terminus of major histocompatibility complex class II-associated peptides
14. Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells
15. Reduction of disulphide bonds within lysosomes is a key step in antigen processing
16. Binding to Ia protects an immunogenic peptide from proteolytic degradation
17. MHC molecules protect T cell epitopes against proteolytic destruction
18. Two structural states of peptide-class II MHC complexes revealed by photoaffinity labeled peptides
19. Crystal structure of I-A(k) in complex with a dominant epitope of lysozyme
20. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein
21. Presentation of antigens internalized through the B cell receptor requires newly synthesized MHC class II molecules
22. Immunodominance: Intramolecular competition between T cell epitopes
23. Interference with the binding of a naturally processed peptide to class II alters the immunodominance of T cell epitopes in vivo
24. Immunodominance does not result from peptide competition for MHC class II presentation