Improved high-performance liquid chromatographic method for analysis of L-carnitine in pharmaceutical formulations

Journal of Pharmaceutical and Biomedical Analysis

Volumn 23, Issue 2-3, 2000, Pages 315-321

  He, Gong Xin ^a   Dahl, Terry ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

L Carnitine; Pharmaceutical formulations; Quantitative analysis; Reversed phase high performance liquid chromatography

Indexed keywords

CARNITINE; CROTONOYLBETAINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CALIBRATION; DRUG CAPSULE; DRUG DETERMINATION; DRUG IMPURITY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TABLET; TECHNIQUE;

CALIBRATION; CARNITINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0034664093     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(00)00249-1     Document Type: Article

References (12)

1. Siliprandi N., Sartorelli L., Ciman M., Lisa F.D. Clinica Chimica Acta. 183:1989;3-12.
2. Boehm K.A., Helms R.A., Christensen M.I., Storm M.C. Hosp. Pharm. 28:(843):1993;847-850.
3. Broderick T.L., Christos S.C., Wolf B.A., DiDomenico D., Shug A.L., Paulson D.J. Metabolism. 44:1995;499-505.
4. Melegh B., Pap M., Szekely G., Gage D.A., Sherry A.D., Bieber L.L. J. Nutr. Biochem. 8:1997;147-151.
5. Brass E.P. Clin. Ther. 17:1995;176-185.
6. Simone C.D., Famularo G., Tzantzoglou S., Trinchieri V., Moretti S., Sorice F. AIDS. 8:1994;655-660.
7. C. Vogt, H. Seim, HPLC and capillary electrophoresis in carnitine analysis, in: H. Seim, H. Loester (Eds.), Carnitine: Pathobiochem. Basics Clin. Appl., Proc. Leipzig Carnitine Symp. Ponte Press, Bochum, 1996, pp. 85-94.
8. Bongo A., Bruno G., Curti S., Mancinelli A., Miotto G. J. Chromatogr. B Biomed. Appl. 686:1996;129-139.
9. Kuroda N., Ohyama Y., Nakashima K., Nakashima K., Akiyama S. Chem. Pharm. Bull. 44:1996;1525-1529.
10. United States Pharmacopeia, 23rd ed., Rand McNally, Taunton, MA, 1994, pp. 877-878.
11. United States Pharmacopeia, 23rd ed., Rand McNally, Taunton, MA, 1994, pp. 878-879.
12. Both the USP methods and this method are not designed for the analysis of the optical purity of L-carnitine in pharmaceutical formulations. In USP monographs, the optical purity is determined for L-carnitine drug substance using specific rotation. United States Pharmacopeia, 23rd ed., Rand McNally, Taunton, MA, 1994, pp. 877.