High-performance cation-exchange chromatography and pulsed amperometric detection for the separation, detection, and quantitation of N-alkylated imino sugars in biological samples

Analytical Biochemistry

Volumn 284, Issue 1, 2000, Pages 136-142

  Mellor, H R ^a   Adam, A ^b   Platt, F M ^a   Dwek, R A ^a   Butters, T D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Dionex UK Ltd   (United Kingdom)

Author keywords

Imino sugar inhibitors; Lysosomal glycolipid storage diseases; Pulsed amperometry

Indexed keywords

BIOCHEMISTRY; HYDROPHOBICITY; POSITIVE IONS; SEPARATION; SUGARS; VIRUSES;

CATION EXCHANGE CHROMATOGRAPHY; GLYCO LIPIDS; HIGH-PERFORMANCE CATION EXCHANGE CHROMATOGRAPHY; HYDROPHOBIC INTERACTIONS; IMINOSUGARS; PULSED AMPEROMETRIC DETECTION; PULSED AMPEROMETRY; QUANTITATIVE MEASUREMENT;

CHROMATOGRAPHY;

IMINO ACID;

AMPEROMETRY; ARTICLE; BIOAVAILABILITY; CARBOHYDRATE ANALYSIS; CHEMICAL STRUCTURE; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR INTERACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RELIABILITY; STORAGE DISEASE;

EID: 0034663565     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2000.4678     Document Type: Article

References (14)

1. Inhibitors of glycosphingolipid biosynthesis
2. New therapeutic prospects for the glycosphingolipid lysosomal storage diseases
3. Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin
4. Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin
5. Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking
6. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
7. Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis
8. Evaluation of HPLC with pulsed-amperometric detection for analysis of an aminosugar drug substance
9. Extensive glycosphingolipid depletion in the liver and lymphoid organs of mice treated with N-butyldeoxynojirimycin
10. The use of HPLC-pulsed amperometry for the characterisation and assay of glycosidases and glycosyltransferases
11. N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis
12. N-butyldeoxygalactonijirimycin inhibits glycolipid biosynthesis but does not affect N-linked oligosaccharide processing
13. N-Butyldeoxygalactonojirimycin: A more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo
14. Separation of positional isomers of oligosaccharides and glycopeptides by highperformance anion-exchange chromatography with pulsed amperometric detection