Inhibition of tetanus toxin fragment C binding to ganglioside G(T1b) by monoclonal antibodies recognizing different epitopes

Vaccine

Volumn 19, Issue 1, 2000, Pages 114-121

  Fitzsimmons, Sean P ^a   Clark, Kathleen C ^a   Wilkerson, Rashad ^a   Shapiro, Marjorie A ^a  

^a Ctr Biologics Eval Res Food D   (United States)

Author keywords

Ganglioside G(T1b); Monoclonal antibodies; Tetanus toxin fragment C

Indexed keywords

EPITOPE; GANGLIOSIDE GT 1B; MONOCLONAL ANTIBODY; PEPTIDE FRAGMENT; TETANUS TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; FEMALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; TOXIN STRUCTURE;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; CROSS REACTIONS; EPITOPES, B-LYMPHOCYTE; FEMALE; GANGLIOSIDES; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TETANUS TOXIN;

EID: 0034663508     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00115-8     Document Type: Article

References (21)

1. Schiavo G., Rossetto O., Montecucco C. Clostridial neurotoxins as tools to investigate the molecular events of neurotransmitter release. Semin. Cell Biol. 5:1994;221-229.
2. Fry M., Edwards G., Taylor A. Tetanus - the silent killer: how safe are you? Aust. Crit. Care. 11:1998;82-85.
3. Montecucco C., Schiavo G. Structure and function of tetanus and botulinum neurotoxins. Q. Rev. Biophys. 28:1995;423-472.
4. Eisel U., Jarausch W., Goretzki K., Henschen A., Engels J., Weller U., Hudel M., Habermann E., Niemann H. Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins. EMBO J. 5:1986;2495-2502.
5. Matsuda M., Yoneda M. Dissociation of tetanus neurotoxin into two polypeptide fragments. Biochem. Biophys. Res. Commun. 57:1974;1257-1262.
6. Helting T.B., Zwisler O. Structure of tetanus toxin. I. Breakdown of the toxin molecule and discrimination between polypeptide fragments. J. Biol. Chem. 252:1977;187-193.
7. Halpern J.L., Neale E.A. Neurospecific binding, internalization, and retrograde axonal transport. Curr. Top Microbiol. Immunol. 195:1995;221-241.
8. Halpern J.L., Habig W.H., Neale E.A., Stibitz S. Cloning and expression of functional fragment C of tetanus toxin. Infect. Immun. 58:1990;1004-1009.
9. Williamson L.C., Bateman K.E., Clifford J.C., Neale E.A. Neuronal sensitivity to tetanus toxin requires gangliosides. J. Biol. Chem. 274:1999;25173-25180.
10. Kitamura M., Takamiya K., Aizawa S., Furukawa K. Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice. Biochim. Biophys. Acta. 1441:1999;1-3.
11. Lalli G., Herreros J., Osborne S.L., Montecucco C., Rossetto O., Schiavo G. Functional characterisation of tetanus and botulinum neurotoxins binding domains. J. Cell Sci. 112:1999;2715-2724.
12. Jahn R., Hanson P.I., Otto H., Ahnert-Hilger G. Botulinum and tetanus neurotoxins: emerging tools for the study of membrane fusion. Cold Spring Harb. Symp. Quant. Biol. 60:1995;329-335.
13. Montecucco C. How do tetanus and botulinim toxins bind to neuronal membranes? Trends Biochem. Sci. 11:1986;314-317.
14. Kenimer J.G., Habig W.H., Hardegree M.C. Monoclonal antibodies as probes of tetanus toxin structure and function. Infect. Immun. 42:1983;942-948.
15. Halpern J.L., Loftus A. Characterization of the receptor-binding domain of tetanus toxin. J. Biol. Chem. 268:1993;11188-11192.
16. Current protocols in immunology. New York: Wiley, 1992.
17. Huse W.D., Sastry L., Iverson S.A., Kang A.S., Alting-Mees M., Burton D.R., Benkovic S.J., Lerner R.A. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science. 246:1989;1275-1281.
18. Caton A.J., Swartzentruber J.R., Kuhl A.L., Carding S.R., Stark S.E. Activation and negative selection of functionally distinct subsets of antibody-secreting cells by influenza hemagglutinin as a viral and a neo-self antigen. J. Exp. Med. 183:1996;13-26.
19. Pierce E.J., Davison M.D., Parton R.G., Habig W.H., Critchley D.R. Characterization of tetanus toxin binding to rat brain membranes. Evidence for a high-affinity proteinase-sensitive receptor. Biochem. J. 236:1986;845-852.
20. Umland T.C., Wingert L.M., Swaminathan S., Furey W.F., Schmidt J.J., Sax M. Structure of the receptor binding fragment HC of tetanus neurotoxin [letter]. Nat. Struct. Biol. 4:1997;788-792.
21. Habig W.H., Neale E.A., Kenimer J.G., Groover K.A., Halpern J.L., Hardegree M.C. Properties of a unique monoclonal antibody against tetanus toxin. Nistico G., Bizzini B., Bytchenko B., Triau R. Eighth International Conference on Tetanus. 1989;66-70 Pythagora Press, Rome.