Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody

Cancer Research

Volumn 60, Issue 16, 2000, Pages 4453-4460

  Foulon, C F ^a   Reist, C J ^a   Bigner, D D ^a   Zalutsky, M R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DEXTRO ARGININE; DEXTRO LYSINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III MONOCLONAL ANTIBODY; IODOGEN; MALEIMIDE DERIVATIVE; MONOCLONAL ANTIBODY; PENTAPEPTIDE; POLYCATION; RADIOISOTOPE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CANCER; CONTROLLED STUDY; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RADIOACTIVITY; RADIOIMMUNOTHERAPY; RADIOIODINATION; TISSUE DISTRIBUTION; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; CATIONS; GLIOMA; HUMANS; IMMUNOCONJUGATES; IODINE RADIOISOTOPES; ISOTOPE LABELING; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; OLIGOPEPTIDES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STEREOISOMERISM; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0034662647     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Growth factor receptors as molecular targets for cancer diagnosis and therapy
2. The class III variant of the epidermal growth factor receptor (EGFRvIII): Characterization and utilization as an immunotherapeutic target
3. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C- terminal tails
4. Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma
5. Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors
6. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
7. Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor. EGFRvIII
8. Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: Use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts
9. Improving the tumor retention of radioiodinated antibody: Aryl carbohydrate adducts
10. Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridine-carboxylate: In vitro studies
11. Improved targeting of an anti-EGFRvIII monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate
12. In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: Comparison with its murine parent
13. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
14. Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess
15. Intracellular catabolism of radiolabeled anti-CD3 antibodies by leukemic T cells
16. Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies
17. Total chemical synthesis of a D-enzyme: The enantiomers of HIV-1 protease show demonstration of reciprocal chiral substrate specificity
18. The fate of peptides pinocytosed by macrophages in vitro
19. Intestinal absorption and excretion of octapeptides composed of D amino acids
20. Absorption and excretion of undegradable peptides: Role of lipid solubility and net charge
21. In vivo use of a radioiodinated somatostatin analogue: Dynamics, metabolism, and binding to somatostatin receptor-positive tumors in man
22. Enhanced binding and inertness to dehalogenation of α-melanotropic peptides labeled using. N-succinimidyl 3-iodobenzoate
23. 2 fragment
24. Specificity of thyroidal and hepatic microsomal iodotyrosine deiodinase
25. Monoiodo-D-tyrosine, an artificial amino acid radiopharmaceutical for selective measurement of membrane amino acid transport in the pancreas
26. Filtration, transport, and metabolism of proteins
27. Studies of renal tubular protein absorption: Partial and near complete inhibition by certain amino acids
28. D-Lysine reduction of indium-111 octrotide and yttrium-90 octrotide renal uptake
29. Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives
30. Labeling of monoclonal antibodies with diethylenetriaminepentaacetic acid-appended radioiodinated peptides containing D-amino acids
31. Effects of radiolabeling monoclonal antibodies with a residualizing iodine radiolabel on the accretion of radioisotope in tumors