Metabolism and pharmacokinetics of N1, N11-diethylnorspermine in a Cebus apella primate model

Cancer Research

Volumn 60, Issue 16, 2000, Pages 4433-4439

  Bergeron, Raymond J ^a   Merriman, Ronald L ^c   Olson, Stephen G ^c   Wiegand, Jan ^a   Bender, John ^c   Streiff, Richard R ^a,b   Weimar, William R ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; N(1),N(11) DIETHYLNORSPERMINE; N(1),N(11)-DIETHYLNORSPERMINE; SPERMINE; 1,3 PROPANEDIAMINE; ETHYLDIAMINOPROPANE; ETHYLNORSPERMIDINE; ETHYLNORSPERMINE; N1,N11 DIETHYLNORSPERMINE; NORSPERMIDINE; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CEBIDAE; COMPARATIVE STUDY; DOG; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; URINE; ANIMAL EXPERIMENT; CANCER; CONTROLLED STUDY; DRUG DISPOSITION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG URINE LEVEL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CEBUS; DOGS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; SPECIES SPECIFICITY; SPERMINE; TISSUE DISTRIBUTION;

EID: 0034662497     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy
2. Polyamines as targets for therapeutic intervention
3. Inhibition of basic amino acid decarboxylases involved in polyamine biosynthesis
4. Methyl glyoxal bis-(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases
5. Aspects of the biochemical pharmacology of methyl glyoxal bis(guanylhydrazone)
6. Inhibitors of polyamine biosynthesis: Cellular and in vivo effects on tumor proliferation
7. S-Adenosylmethionine decarboxylase as an enzyme target for therapy
8. Clinical aspects of inhibition of ornithine decarboxylase with emphasis on the therapeutic trials of Eflornithine (DFMO) in cancer and protozoan diseases
9. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity
10. Pharmacodynamic confirmation of CGP-48664 as an inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC) in an advanced melanoma patient
11. Polyamine transport in mammalian cells
12. Synthetic polyamine analogues as antineoplastics
13. Antiproliferative properties of polyamine analogues: A structure-activity study
14. Antitumor activity of N, N′-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts
15. Aliphatic chain length specificity of the polyamine transport system in ascites L1210 leukemia cells
16. 8-spermidine derivatives in cultured L1210 leukemia cells
17. Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells
18. 12-bis(ethyl)spermine
19. Control of ornithine decarboxylase activity in α-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues
20. Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth
21. 1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines
22. 1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells
23. 1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues
24. 12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells
25. Structure-function correlations of polyamine analog-induced increases in spermidine/spermine acetyltransferase activity
26. 8-bis(ethyl)spermidine
27. 11-diethylnorspermine
28. 14-diethylhomospermine
29. A comparative evaluation of iron chelators in a primate model
30. A comparison of the iron-clearing properties of 1, 2-dimethyl-3-hydroxypyrid-4-one, 1, 2-diethyl-3-hydroxypyrid-4-one, and deferoxamine
31. Determination of free and total polyamines in human serum and urine by ion pairing high-performance liquid chromatography using a radial compression module
32. Solid-phase extraction and determination of dansyl derivatives of unconjugated and acctylated polyamines by reverse-phase liquid chromatography: Improved separation systems for polyamines in cerebrospinal fluid, urine, and tissue