The iron-responsive regulator Fur of Campylobacter jejuni is expressed from two separate promoters

FEMS Microbiology Letters

Volumn 188, Issue 2, 2000, Pages 115-118

  Van Vliet, Arnoud H M ^a   Rock, Jonathan D ^a   Madeleine, Laetitia N ^a   Ketley, Julian M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Fur protein; Gene regulator; Iron responsive regulator

Indexed keywords

PROTEIN;

ARTICLE; CAMPYLOBACTER JEJUNI; GENE CONTROL; GENE EXPRESSION; GENETIC ORGANIZATION; GENOME; IRON RESPONSIVE ELEMENT; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

BACTERIAL PROTEINS; CAMPYLOBACTER JEJUNI; IRON; LAC OPERON; METALLOPROTEINS; OPEN READING FRAMES; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS;

CAMPYLOBACTER JEJUNI; NEGIBACTERIA;

EID: 0034662454     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(00)00222-6     Document Type: Article

References (20)

1. Litwin C.M., Calderwood S.B. Role of iron in regulation of virulence genes. Clin. Microbiol. Rev. 6:1993;137-149.
2. Escolar L., Perez-Martin J., de Lorenzo V. Opening the iron box: transcriptional metalloregulation by the Fur protein. J. Bacteriol. 181:1999;6223-6229.
3. Bsat N., Herbig A., Casillas-Martinez L., Setlow P., Helmann J.D. Bacillus subtilis contains multiple Fur homologues: identification of the iron-uptake (Fur) and peroxide regulon (PerR) repressors. Mol. Microbiol. 29:1998;189-198.
4. De Lorenzo V., Herrero M., Giovannini F., Neilands J.B. Fur (ferric uptake regulation) protein and CAP (catabolite-activator protein) modulate transcription of fur gene in Escherichia coli. Eur. J. Biochem. 173:1988;537-546.
5. Litwin C.M., Boyko S.A., Calderwood S.B. Cloning, sequencing, and transcriptional regulation of the Vibrio cholerae fur gene. J. Bacteriol. 174:1992;1897-1903.
6. Staggs T.M., Perry R.D. Fur regulation in Yersinia species. Mol. Microbiol. 6:1992;2507-2516.
7. Watnick P.I., Eto T., Takahashi H., Calderwood S.B. Purification of Vibrio cholerae Fur and estimation of its intracellular abundance by antibody sandwich enzyme-linked immunosorbent assay. J. Bacteriol. 179:1997;243-247.
8. Zheng M., Doan B., Schneider T.D., Storz G. OxyR and SoxRS regulation of fur. J. Bacteriol. 181:1999;4639-4643.
9. van Vliet A.H.M., Wooldridge K.G., Ketley J.M. Iron-responsive gene regulation in a Campylobacter jejuni fur mutant. J. Bacteriol. 180:1998;5291-5298.
10. van Vliet A.H.M., Baillon M.L.A., Penn C.W., Ketley J.M. Campylobacter jejuni contains two Fur homologs: Characterisation of iron-responsive regulation of peroxide stress defence genes by the PerR repressor. J. Bacteriol. 181:1999;6371-6376.
11. Wooldridge K.G., Williams P.H., Ketley J.M. Iron-responsive genetic regulation in Campylobacter jejuni: cloning and characterization of a fur homolog. J. Bacteriol. 176:1994;5852-5856.
12. Chan V.L., Louie H., Bingham H.L. Cloning and transcription regulation of the ferric uptake regulatory gene of Campylobacter jejuni TGH9011. Gene. 164:1995;25-31.
13. Wosten M.M.S.M., Boeve M., Koot M.G., van Nuenen A.C., van der Zeijst B.A.M. Identification of Campylobacter jejuni promoter sequences. J. Bacteriol. 180:1998;594-599.
14. King V., Wassenaar T.M., van der Zeijst B.A.M., Newell D.G. Variations in Campylobacter jejuni flagellin, and flagellin genes, during in vivo and in vitro passage. Microb. Ecol. Health Dis. 4:1991;135-140.
15. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
16. van Vliet A.H.M., Wood A.C., Henderson J., Wooldridge K.G., Ketley J.M. Genetic manipulation of enteric Campylobacter species. Methods Microbiol. 27:1998;407-419.
17. Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. Baillon M.L.A., van Vliet A.H.M., Ketley J.M., Constantinidou C., Penn C.W. An iron-regulated alkyl hydroperoxide reductase (AhpC) confers aerotolerance and oxidative stress resistance to the microaerophilic pathogen Campylobacter jejuni. J. Bacteriol. 181:1999;4798-4804.
19. Parkhill J., Wren B.W., Mungall K., Ketley J.M., Churcher C., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quall M.A., Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S., Barrell B.G. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature. 403:2000;665-668.
20. Tomb J.F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A., Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B., Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K., Fitzegerald L.M., Lee N., Adams M.D., Venter J.C. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 388:1997;539-547.