Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system

Journal of Ethnopharmacology

Volumn 70, Issue 3, 2000, Pages 275-280

  Nogueira, E ^a   Vassilieff, V S ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Anticonvulsant; Benzodiazepine like principle; Hexanic fraction; Hypnosis; Muscle relaxation; Rubus brasiliensis

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE RECEPTOR; DIAZEPAM; FLUMAZENIL; HYPNOTIC AGENT; MUSCLE RELAXANT AGENT; PENTETRAZOLE; PENTOBARBITAL; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; GABAERGIC SYSTEM; HYPNOSIS; LATENT PERIOD; MALE; MOUSE; MUSCLE RELAXATION; NONHUMAN; SLEEP TIME;

ANIMALS; ANTICONVULSANTS; BARBITURATES; BRAZIL; DIAZEPAM; FLUMAZENIL; GABA MODULATORS; HEXANES; HYPNOTICS AND SEDATIVES; MALE; MICE; MUSCLE RELAXANTS, CENTRAL; PENTYLENETETRAZOLE; PLANT EXTRACTS; PLANTS, MEDICINAL; RECEPTORS, GABA-A; SEIZURES;

EID: 0034662386     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(99)00205-6     Document Type: Article

References (19)

1. Albertson, T.E., Bowyer, J.F., M.G., 1982. Modification of the anticonvulsant efficacy of diazepam by Ro 15-1788 in the kindley amygdaloid seizure model. Life Science 31, 1597-1601.
2. Balbach A., Boarim D. As Frutas na Medicina Natural. 1992;50-217 Vida Plena Edições, São Paulo.
3. Batatinha M.J.M., Spinosa-Souza H., Bernardi M.M. Croton zehntneri: possible central nervous system effects of the essential oil in rodents. Jounal of Ethnopharmacology. 45:1995;53-57.
4. Bennett D.A., Petrack B. CGS 9896: a non-benzodiazepine, nonsedating potential anxiolytic. Drug Developed Research. 4:1984;75-82.
5. Bernard P.S., Bennett D.A., Pastor G., Yokoyama N., Liebman J.M. CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents. Journal Experimental Therapeutic. 235:1985;98-105.
6. Billingsley M.L., Kubena R.K. The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines. Life Science. 22:1978;897-906.
7. Carlini E.A., Contar J.A.R., Silva-Filho A.R., Silveira-Filho N.G., Frochtengarten M.N., Bueno O.F.A. Pharmacology of lemongrass (Cymbopogon citratus Staph). I: Effects of teas prepared from the leaves laboratory animals. Journal of Pharmacology. 17:1986;37-64.
8. Cook L., Sepinwall J. Behavioral analysis of the effects of and mechanisms of action of benzodiazepines. Costa E., Greengard P. Mechanism of Action of Benzodiazepines. 1975;1-28 Raven Press, New York.
9. File S.E., Lister R.G., Nutt D.J. The anxiogenic actions of benzodiazepine antagonists. Neuropharmacology. 21:1982;1033-1037.
10. File S.E., Pellow S. Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacology. 88:1986;1-11.
11. Friedman S.L., Ingalls J.W. A note the tilting-plane tecnique for measuring the performace of rats in relation to the degree of their alcohol intoxication. Q. Journal Study Alcohol. 21:1960;217-222.
12. Lee C.M., Wong H.N.C., Chui K.Y., Choang T.F., Hon P.M., Chang H.M. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese madicinal herb Salvia miltiorrhiza. Neuroscience. 127:1991;237-241.
13. Medina J., Peña C., Piva M., Paladini C.A., De Robertis E. Presence of benzodiazepine-like molecules in mammalian brain and milk. Biochemistry Biophysical Research Communication. 152:1988;534-539.
14. Nielsen M., Frokjaer S., Braestrup C. High affinity of naturally occurring biflavonoid, amentoflavone to brain benzodiazepine receptors in vitro. Biochemistry Pharmacology. 37:1988;3285-3287.
15. Nogueira E., Rosa G.J.M., Haraguchi M., Vassilieff V.S. Anxiolytic effect of Rubus brasiliensis in rats and mice. Journal of Ethnopharmacology. 61:1998;111-117.
16. A-benzodiazepine receptor in the anxiolytic effect by hexanic fraction of Rubus brasiliensis. Journal of Ethnopharmacology. 61:1998;119-126.
17. Rosenberg H.C., Tietz E.I., Chiu T.H. Tolerance to anticonvulsant action of benzodiazepines. Relationship to decreased receptor density. Neuropharmacology. 24:1985;639-644.
18. Snedecor G.W., Cohran W.G. Statistical Methods. The Iowa State University Press, p. 593. 6:1980.
19. Wolfman C., Viola H., Paladini A., Dajas F., Medina J.H. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligant isolated from Passiflora coerulea. Pharmacology Biochemistry and Behavior. 47:1994;1-4.