Deficient homologous desensitization of formyl peptide receptors stably expressed in undifferentiated HL-60 cells

Biochemical Pharmacology

Volumn 60, Issue 2, 2000, Pages 179-187

  Rane, Madhavi J ^a   Prossnitz, Eric R ^b   Arthur, John M ^a   Ward, Richard A ^a   McLeish, Kenneth R ^a,c,d,e  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Desensitization; Formyl peptide; G proteins; HL 60 cells; receptors

Indexed keywords

DIMETHYL SULFOXIDE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORMYLPEPTIDE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MEMBRANE RECEPTOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; GRANULOCYTE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERNALIZATION; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

CELL DIFFERENTIATION; GRANULOCYTES; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HL-60 CELLS; HUMANS; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PEPTIDE; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0034662378     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00313-0     Document Type: Article

References (40)

1. Murphy P.M. The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol. 12:1994;593-633.
2. McLeish K.R., Jakobs K.H. G-proteins in the signal transduction of the neutrophil. Dickey B.F., Birnbaumer L., GTPases in Biology II. 1993;363-373 Springer, Berlin.
3. McLeish K.R., Gierschik P., Jakobs K.H. Desensitization uncouples the formyl peptide receptor-guanine nucleotide-binding protein interaction in HL60 cells. Mol Pharmacol. 36:1989;384-390.
4. Wilde M.W., Carlson K.E., Manning D.R., Zigmond S.H. Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant. J Biol Chem. 264:1989;190-196.
5. Gerard C., Gerard N.P. The pro-inflammatory seven-transmembrane segment receptors of the leukocyte. Curr Opin Immunol. 6:1994;140-145.
6. Kunz D., Gerard N.P., Gerard C. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J Biol Chem. 267:1992;9101-9106.
7. 4 that mediates chemotaxis. Nature. 387:1997;620-624.
8. Giannini E., Boulay F. Phosphorylation, dephosphorylation, and recycling of the C5a receptor in differentiated HL60 cells. J Immunol. 154:1995;4055-4064.
9. Ali H., Richardson R.M., Tomhave E.D., Didsbury J.R., Snyderman R. Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. J Biol Chem. 268:1993;24247-24254.
10. Prossnitz E.R. Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation. J Biol Chem. 272:1997;15213-15219.
11. Mueller S.G., White J.R., Schraw W.P., Lam V., Richmond A. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. J Biol Chem. 272:1997;8207-8214.
12. Tardif M., Mery L., Brouchon L., Boulay F. Agonist-dependent phosphorylation of N-formylpeptide and activation peptide from the fifth component C (C5a) chemoattractant receptors in differentiated HL60 cells. J Immunol. 150:1993;3534-3545.
13. Prossnitz E.R., Kim C.M., Benovic J.L., Ye R.D. Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J Biol Chem. 270:1995;1130-1137.
14. Lederer E.D., Jacobs A.A., McLeish K.R. Desensitization by protein kinase C activation differentially uncouples formyl peptide receptors from effector enzymes in HL-60 granulocytes. Cell Signal. 5:1993;735-745.
15. Kikuchi A., Kozawa O., Hamamori Y., Kaibuchi K., Takai Y. Inhibition of chemotactic peptide-induced phosphoinositide hydrolysis by phorbol esters through the activation of protein kinase C in differentiated human leukemia (HL-60) cells. Cancer Res. 46:1986;3401-3406.
16. Smith C.D., Uhing R.J., Snyderman R. Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. J Biol Chem. 262:1987;6121-6127.
17. 4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils. J Biol Chem. 260:1985;2125-2131.
18. Ali H., Fisher I., Haribabu B., Richardson R.M., Snyderman R. Role of phospholipase Cβ3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. J Biol Chem. 272:1997;11706-11709.
19. O'Flaherty J.T., Jacobson D.P., Redman J.F. Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils. Biochem J. 288:1992;241-248.
20. Richardson R.M., Haribabu B., Ali H., Snyderman R. Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. J Biol Chem. 271:1996;28717-28724.
21. Richardson R.M., Dubose R.A., Ali H., Tomhave E.D., Haribabu B., Snyderman R. Regulation of human interleukin-8 receptor A Identification of a phosphorylation site involved in modulating receptor functions . Biochemistry. 34:1995;14193-14201.
22. Mueller S.G., Schraw W.P., Richmond A. Activation of protein kinase C enhances the phosphorylation of the type B interleukin-8 receptor and stimulates its degradation in non-hematopoietic cells. J Biol Chem. 270:1995;10439-10448.
23. Kew R.R., Peng T., DiMartino S.J., Madhavan D., Weinman S.J., Cheng D., Prossnitz E.R. Undifferentiated U937 cells transfected with chemoattractant receptors A model system to investigate chemotactic mechanisms and receptor structure/function relationships . J Leukoc Biol. 61:1997;329-337.
24. Prossnitz E.R., Quehenberger O., Cochrane C.G., Ye R.D. Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells. J Immunol. 151:1993;5704-5715.
25. Goldsmith P., Gierschik P., Milligan G., Unson C.G., Vinitsky R., Malech H.L., Spiegel A.M. Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. J Biol Chem. 262:1987;14683-14688.
26. Gierschik P., Falloon J., Milligan G., Pines M., Gallin J.I., Spiegel A. Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils. J Biol Chem. 261:1986;8058-8062.
27. 4 receptors. J Biol Chem. 267:1992;159-165.
28. Rane M.J., Arthur J.M., Prossnitz E.R., McLeish K.R. Activation of mitogen-activated protein kinases by formyl peptide receptors is regulated by the cytoplasmic tail. J Biol Chem. 273:1998;20916-20923.
29. 2+ indicators with greatly improved fluorescence properties. J Biol Chem. 260:1985;3440-3450.
30. Rane M.J., Carrithers S.L., Arthur J.M., Klein J.B., McLeish K.R. Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways. Role in activation of reduced nicotinamide adenine dinucleotide oxidase. J Immunol. 159:1997;5070-5078.
31. Tomhave E.D., Richardson R.M., Didsbury J.R., Menard L., Snyderman R., Ali H. Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. J Immunol. 153:1994;3267-3275.
32. Hausdorff W.P., Caron M.G., Lefkowitz R.J. Turning the signal off Desensitization of β-adrenergic receptor function . FASEB J. 4:1990;2881-2889.
33. - lymphoma cells. J Cyclic Nucleotide Protein Phosphor Res. 10:1985;97-119.
34. Hausdorff W.P., Campbell P.T., Ostrowski J., Yu S.S., Caron M.G., Lefkowitz R. A small region of the β-adrenergic receptor is selectively involved in its rapid regulation. Proc Natl Acad Sci USA. 88:1991;2979-2983.
35. 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem. 264:1989;12657-12665.
36. Cheung A.H., Dixon R.A.F., Hill W.S., Sigal I.S., Strader C.D. Separation of the structural requirements for agonist-promoted activation and sequestration of the β-adrenergic receptor. Mol Pharmacol. 37:1990;775-779.
37. Strader C.D., Sigal I.S., Blake A.D., Cheung A.H., Register R.B., Rands E., Zemcik B.A., Candelore M.R., Dixon R.A.F. The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration. Cell. 49:1987;855-863.
38. s interfere with receptor down-regulation but not sequestration. Mol Pharmacol. 39:1991;192-198.
39. 2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature. 333:1988;370-373.
40. Didsbury J.R., Uhing R.J., Tomhave E.D., Gerard C., Gerard N., Snyderman R. Receptor class desensitization of leukocyte chemoattractant receptors. Proc Natl Acad Sci USA. 88:1997;11564-11568.