Hepatic intralobular mapping of fructose metabolism in the rat liver

Biochemical Journal

Volumn 349, Issue 2, 2000, Pages 539-545

  Burns, Shamus P ^a   Murphy, Helena C ^a   Iles, Richard A ^a   Bailey, Rosemary A ^b   Cohen, Robert D ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Fructose 1 phosphate; Hepatic glucose output; Intracellular pH; Lactate uptake

Indexed keywords

ESTER DERIVATIVE; FRUCTOKINASE; FRUCTOSE; FRUCTOSE 1 PHOSPHATE; GLUCOSE; LACTIC ACID; PHOSPHORUS 31;

ANIMAL TISSUE; ARTICLE; CELL PH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; FRUCTOSE METABOLISM; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; LIVER; MALE; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PORTAL VEIN; PRIORITY JOURNAL; RAT;

ANIMALS; FRUCTOSE; FRUCTOSEPHOSPHATES; GLUCOSE; LACTIC ACID; LIVER; MALE; RATS; RATS, WISTAR;

EID: 0034661837     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3490539     Document Type: Article

References (28)

1. 1 Woods, H. F., Eggleston, L. V. and Krebs, H. A. (1970) The cause of hepatic accumulation of fructose 1-phosphate on fructose loading. Biochem. J. 119, 501-510
2. 2 Woods, H. F. and Alberti, K. G. G. M. (1972) Dangers of intravenous fructose. Lancet II, 1354-1357
3. 31phosphorus nuclear magnetic resonance study. Biochem. J. 192, 191-202
4. 4 Sahebjami, H. and Scalettar, R. (1971) Effects of fructose infusion on lactate and uric acid metabolism. Lancet 1, 366-369
5. 31P magnetic resonance spectroscopy. Lancet II, 931-934
6. 6 Gitzelmann, R., Steinmann, B. and Van Den Berghe, G. (1989) Disorders of fructose metabolism. In The Metabolic Basis of Inherited Disease, vol. 1. (Scriver, C. R., Beaudet, A. L., Sly, W. S. and Valle, D., eds.), pp. 407-425, McGraw-Hill, New York
7. 7 Anundi, I., Kauffman, F. C. and Thurman, R. C. (1987) Gluconeogenesis from fructose predominates in periportal regions of the liver lobule. J. Biol. Chem. 262, 9529-9534
8. 8 Suzuki-Kemmelmeier, F., Ishii-lwamoto, E. L. and Bracht, A. (1992) The metabolism of fructose in the bivascularly perfused rat liver. Biochim. Biophys. Acta 1116, 275-282
9. 9 Cohen, R. D., Henderson, R. M., Iles, R. A. and Smith, J. A. (1982) Metabolic interrelationships of intracellular pH measured by double-barrelled micro-electrodes in perfused rat liver. J. Physiol. 330, 69-80
10. 10 Burns, S. P., Cohen, R. D., Iles, R. A., Germain, J. P., Going, T. C. H., Evans, S. J. W. and Royston, P. (1996) A method for determination in situ of variations within the hepatic lobule of hepatocyte function and metabolite concentrations. Biochem. J. 319, 377-383
11. 11 Cohen, R. D., Iles, R. A., Barnett, D., Howell, M. E. O. and Strunin, J. The effect of changes in lactate uptake on the intracellular pH of the perfused rat liver. (1971) Clin. Sci 41, 159-170
12. 12 Krebs, H. A. and Henseleit, K. (1932) Untersuchungen über die Harnstoffbildung im Tierkörper. Hoppe-Seyler's Z. Physiol. Chem 210, 33-36
13. 13 Quistorff, B. and Romert, P. (1989) High zone-selectivity of cell permeabilization following digitonin-pulse perfusion of rat liver. A re-interpretation of the microcirculatory zones. Histochemistry 92, 487-498
14. 14 Racine, L., Scoazec, J., Moreau, A., Bernuau, D. and Feldmann, G. (1993) Effects of digitonin on the intracellular content of rat hepatocytes: implications for its use in the study of intralobular heterogeneity. J. Histochem. Cytochem. 7, 991-1001
15. 15 Burns, S. P., Desai, M., Cohen, R. D., Hales, C. N., Iles, R. A., Germain, J. P., Going, T. C. H. and Bailey, R. A. (1997) Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J. Clin. Invest 100, 1768-1774
16. 1H NMR-based absolute quantitation of human lipoproteins and their lipid contents directly from plasma. J. Lipid Res. 35, 2292-2304
17. 17 Bergmeyer, H. U. and Bernt, E. (1974) D-Fructose. In Methods of Enzymatic Analysis (Bergmeyer, H. U. ed.), pp.1176-1179, Academic Press, New York
18. 18 Press, W. H., Flannery, B. P., Teukolsky, S. A., Vetterling, W. T. (1988) The Art of Scientific Computing: Numerical Recipes In C, Cambridge University Press. New York
19. 19 Burns, S. P., Cohen, R. D., Iles, R. A., Bailey, R. A., Desai, M., Germain, J. P. and Going, T. C. H. (1999) Zonation of gluconeogenesis, ketogenesis and intracellular pH in livers from normal and diabetic ketoacidotic rats: evidence for intralobular redistribution of metabolic events in ketoacidosis. Biochem. J. 343, 273-280
20. 20 Payne, R. W., Lane, P. W., Digby, P. G. N., Harding, S. A., Leech, P. K., Morgan G. W., Todd, A. D., Thompson, R., Tunnicliffe Wilson, G., Welham, S. J. et al. (1993) Genstat 5 Release 3 Reference Manual, Clarendon Press, Oxford
21. 21 Cohen, R. D. (1990) The metabolic background to acid-base homeostasis and some of its disorders. In The Metabolic and Molecular Basis of Acquired Disease (Cohen, R. D., Lewis, B, Alberti, K. G. M. M. and Denman, A. M. eds.), pp. 962-1001, Baillière Tindall, London
22. 31P nuclear magnetic resonance study in vivo of metabolic abnormalities in rats with acute liver failure. NMR Biomed. 1, 69-73
23. 23 Ui, M. (1966) A role of phosphofructokinase in pH-dependent regulation of glycolysis. Biochim. Biophys. Acta 124, 310-322
24. 24 Shiota, M., Galassetti, P., Monohan, M., Neal, D. W. and Cherrington, A. D. (1998) Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes 47, 867-873
25. 25 Detheux, M., Vandercammen, A. and Van Schaftingen, E. (1991) Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation. Eur. J. Biochem. 200, 553-561
26. 26 Agius, L. and Peak, M. (1993) Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Biochem. J. 296, 785-796
27. 27 Youn, J. H., Youn, M. S. and Bergman, R. N. (1986) Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J. Biol. Chem. 261, 15960-15969
28. 28 Toyoda, Y, Miwa, I., Kamiya, M., Ogiso, S., Nonogaki, N., Aoki, S. and Okuda, J. (1995) Tissue and subcellular distribution of glucokinase in rat liver and their changes during fasting-refeeding. Histochem. Cell Biol 103, 31-38