III. Instantaneous inhibition by compound 48/80 of tissue factor- initiated extrinsic coagulation is mediated by the downregulation of factor VII activation

Archives of Biochemistry and Biophysics

Volumn 377, Issue 2, 2000, Pages 357-365

  Chu, Arthur J ^a   Wang, Zhen Gao ^a   Fox, Melissa J ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

48 80; Extrinsic coagulation; Factor VII; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; COMPOUND 48-80; ENDOTOXIN; PROTHROMBIN; THROMBIN; THROMBOPLASTIN;

ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TEST; DOSE RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; HYDROLYSIS; HYPERCOAGULABILITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0034658664     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2000.1771     Document Type: Article

References (27)

1. Broze G. J. Jr. Tissue factor pathway inhibitor and the revised theory of coagulation. Annu. Rev. Med. 46:1995;103-112.
2. Wildgoose P., Berkner K. L., Kisiel W. Synthesis, purification and characterization of an Arg 152-Glu site-directed mutant of recombinant human blood clotting factor VII. Biochemistry. 29:1990;3413-3420.
3. Camerer E., Kolsto A.-B., Prydz H. Cell biology of tissue factor, the principal indicator of blood coagulation. Thromb. Res. 81:1996;1-41.
4. Girard T. J., Warren L. A., Novotny W. F. Functional significance of the Kunitz-type inhibitor domains of lipoprotein-associated coagulation inhibitor. Nature. 338:1990;518-520.
5. Conkling P. R., Patton K. L., Hannun Y. A., Greenberg C. S., Weinberg J. B. Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. J. Biol. Chem. 31:1989;18440-18444.
6. Pitlick F. A. Concanavalin A inhibits tissue factor coagulant activity. J. Clin. Invest. 55:1975;175-179.
7. Carson S. D. Tissue factor (coagulation factor III) inhibition by apolipoprotein A-II. J. Biol. Chem. 262:1987;718-721.
8. Ettelaie C., James N. J., Wilbourn B., Adam J. M., James N. J., Bruckdorfer K. R. Comparison of the inhibitory effects of ApoB100 and tissue factor pathway inhibitor on tissue factor and the influence of lipoprotein oxidation. Arterioscler. Thromb. Vasc. Biol. 19:1999;1784-1790.
9. Van Ginkel C. J. W., Thorig L., Thompson J., Oh J. I. H., van Aken W. G. Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: Possible pathway for fibrin formation on infected vegetations in bacterial endocoritis. Infect. Immun. 25:1979;388-395.
10. Levi M., Ten Cate H., Bauer K. A., Van der Poll T., Edgington T. S., Buller H. R., Van Devnter S. J. H., Hack C. E., Ten Cate J. W., Rosenberg R. D. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J. Clin. Invest. 93:1994;114-120.
11. Gregory S. A., Morrissey J. H., Edington T. S. Regulation of the tissue factor gene expression in the monocyte procoagulant response to endotoxin. Mol. Cell. Biol. 9:1989;2752-2755.
12. Chu A. J., Walton M. A., Prasad J. K., Seto A. Blockade by polyunsaturated n-3 fatty acids of endotoxin recognition is mediated by the altered receptor function in monocytic THP-1 cells. J. Surg. Res. 87:1999;217-224.
13. Chu A. J., Sime R-M., Moore J., Yu W. H., Li Z. Antagonism by ethanol of endotoxin-induced tissue factor activation in relation to the depressed endotoxin binding to monocyte-like U937 cells. Cell Biochem. Funct. 15:1997;271-281.
14. Chu A. J., Prasad J. K. Antagonism by Il-4 and Il-10 of endotoxin-induced tissue factor activation in monocytic THP-1 cells: Activating role of CD14 ligation. J. Surg. Res. 80:1998;80-87.
15. Ternisien C., Ramani M., Ollivier V., Khechai F., Vu T., Hakim J., de Prost D. Endotoxin-induced tissue factor in human monocytes is dependent upon protein kinase C activation. Thromb. Haemost. 70:1993;800-806.
16. Ternisien C., Ollivier V., Khechai F., Ramani M., Hakim J., de Prost D. Protein tyrosine kinase activation is required for LPS and PMA induction of tissue factor mRNA in human blood monocytes. Thromb. Haemost. 73:1995;413-420.
17. Chu A. J., Walton M. A., Seto A., Fox M. J., Prasad J. K., Wang Z. G. I. Suppression by compound 48/80 of bacterial endotoxin-inducible monocytic tissue factor activity: Direct blockade of factor VII binding to THP-1 monocytes. Biochim. Biophys. Acta. 1472:1999;386-395.
18. Chu A. J., Raphael U. O., Prasad J. K., Beydoun S., Ramos N. II. Compound 48/80 suppresses monocytic tissue factor-initiated extrinsic blood coagulation induced by bacterial endotoxin. J. Surg. Res. 87:1999;252-257.
19. Pedersen A. H., Nordfang O., Norris F., Wiberg F. C. Recombinant human extrinsic pathway inhibitor: Production, isolation and characterization of its inhibitory activity on tissue factor-initiated coagulation reactions. J. Biol. Chem. 265:1990;16786-16793.
20. Schmidt R. J., Myers A. M., Gillham N. W., Boynton J. E. Immunological similarities between specific chloroplast ribosomal proteins from Chlamydomonas reinhardtii and ribosomal proteins from Escherichia coli. Mol. Biol. Evol. 1:1984;317-334.
21. Pedersen A. H., Lund-Hansen T., Bisgaard-Frantzen H., Olsen F., Petersen L. C. Autoactivation of human recombinant coagulation factor VII. Biochemistry. 28:1989;9331-9336.
22. Lawson J. H., Butenas S., Mann K. G. The evaluation of complex-dependent alterations in human factor FVIIa. J. Biol. Chem. 267:1992;4834-4843.
23. Nemerson Y. Tissue factor and hemostasis. Blood. 71:1988;1-8.
24. Rao L. V. M., Rapaport S. Activation of factor VII bound to tissue factor: A key early step in the tissue factor pathway of blood coagulation. Proc. Natl. Acad. Sci. USA. 85:1988;6687-6691.
25. Ruf W., Edgington T. S. Structural biology of tissue factor, the initiator of thrombogenesis in vivo. FASEB J. 8:1994;385-390.
26. Ruf W., Edgington T. S. An anti-tissue factor monoclonal antibody which inhibits TF:VIIa complex is a potent anticoagulant in plasma. Thromb. Haemost. 66:1991;529-533.
27. Peterson L. C., Valentin S., Hedner U. Regulation of the extrinsic pathway system in health and disease: The role of factor VIIa and TF pathway inhibitor. Thromb. Res. 79:1995;1-47.