Activation of antibacterial prodrugs by peptide deformylase

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 10, 2000, Pages 1073-1076

  Wei, Yaoming ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ENZYME; FLOXURIDINE DERIVATIVE; LEUCINE; PRODRUG; PROLINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ESCHERICHIA COLI; MOLECULAR INTERACTION; NONHUMAN; STRUCTURE ANALYSIS;

AMIDOHYDROLASES; AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; BACTERIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; DRUG STABILITY; ESCHERICHIA COLI; FLOXURIDINE; MICROBIAL SENSITIVITY TESTS; PRODRUGS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; MAMMALIA; NEGIBACTERIA;

EID: 0034658030     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00167-0     Document Type: Article

References (22)

1. (a) Neu, H. C. Science 1992, 257, 1064.
2. (b) Davis, J. D. Science 1994, 264, 375.
3. (c) Spratt, B. G. Science 1994, 264, 388.
4. (a) Mazel, D.; Pochet, S.; Marliere, P. EMBO J. 1994, 13, 914.
5. (b) Meinnel, T.; Blanquet, S. J. Bacteriol. 1994, 176, 7387.
6. Rajagopalan P.T.R., Yu X.C., Pei D. J. Am. Chem. Soc. 119:1997;12418.
7. Huntington, K. M.; Yi, T.; Wei, Y.; Pei, D. Biochemistry, in press.
8. Santi D.V., McHenry C.S., Raines R.T., Ivanetich K.M. Biochemistry. 26:1987;8606.
9. (a) Gisin, B. F.; Merrifield, R. B. J. Am. Chem. Soc. 1972, 94, 3100.
10. (b) Khosla, M. C.; Smeby, R.; Bumpus, F. M. J. Am. Chem. Soc. 1972, 94, 4721.
11. (c) Rothe, M.; Mazanek, J. Liebigs Ann. Chem. 1974, 439.
12. (d) Pedroso, E.; Grandas, A.; de las Heras, X.; Eritja, R.; Giralt, E. Tetrahedron Lett. 1986, 27, 743.
13. (e) Wipf, P.; Li, W.; Sekhar, V. Bioorg. Med. Chem. Lett. 1991, 1, 745.
14. Mitsunobu, O. Synthesis 1981, 1.
15. (a) Adams, J. M. J. Mol. Biol. 1968, 33, 571.
16. (b) Livingston, D. M.; Leder, P. Biochemistry 1969, 8, 435.
17. Rajagopalan P.T.R., Datta A., Pei D. Biochemistry. 36:1997;13910.
18. Hu Y.-J., Wei Y., Zhou Y., Rajagopalan P.T.R., Pei D. Biochemistry. 38:1999;643.
19. Meinnel T., Patiny L., Ragusa S., Blanquet S. Biochemistry. 38:1999;4287.
20. Pine M.J. Biochim. Biophys. Acta. 174:1969;359.
21. (a) Mazel, D.; Coic, E.; Blanchard, S.; Saurin, W.; Marliere, P. J. Mol. Biol. 1997, 266, 939.
22. (b) Meinnel, T.; Lazennec, C.; Villoing, S.; Blanquet, S. J. Mol. Biol. 1997, 267, 749.