-
1
-
-
0003787448
-
-
(a) Oxford University Press: Oxford
-
(a) Nakanishi, K.; Goto, T.; Ito, S.; Natoro, S.; Nozoe, S., Natural Products Chemistry; Oxford University Press: Oxford, 1983; Vol. 3.
-
(1983)
Natural Products Chemistry
, vol.3
-
-
Nakanishi, K.1
Goto, T.2
Ito, S.3
Natoro, S.4
Nozoe, S.5
-
2
-
-
0020618827
-
-
(b)
-
(b) Fuganti, G.; Grasselli, P.; Pedrocchi-Fantoni, G. J. Org. Chem. 1983, 48, 909.
-
(1983)
J. Org. Chem.
, vol.48
, pp. 909
-
-
Fuganti, G.1
Grasselli, P.2
Pedrocchi-Fantoni, G.3
-
6
-
-
0026090737
-
-
(a) and references cited therein
-
(a) Groth, U.; Schöllkopf, U.; Tiller, T. Tetrahedron 1991, 47, 2835 and references cited therein.
-
(1991)
Tetrahedron
, vol.47
, pp. 2835
-
-
Groth, U.1
Schöllkopf, U.2
Tiller, T.3
-
7
-
-
0003435820
-
-
(b) Merck and Co.: Rahway, NJ
-
(b) Merck Index; 10th ed.; Merck and Co.: Rahway, NJ, 1983; p. 289.
-
(1983)
Merck Index; 10th Ed.
, pp. 289
-
-
-
8
-
-
0024553116
-
-
(c)
-
(c) Bennet, R. B.; Choi, J. R.; Montgomery, W. D.; Cha, J. K. J. Am. Chem. Soc. 1989, 111, 2580.
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 2580
-
-
Bennet, R.B.1
Choi, J.R.2
Montgomery, W.D.3
Cha, J.K.4
-
9
-
-
0028205348
-
-
(a)
-
(a) Beardsley, D. A.; Fisher, G. B.; Goralski, C. T.; Nicholson, L. W.; Singaram, B. Tetrahedron Lett. 1994, 35, 1511.
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 1511
-
-
Beardsley, D.A.1
Fisher, G.B.2
Goralski, C.T.3
Nicholson, L.W.4
Singaram, B.5
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10
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-
0028211409
-
-
(b)
-
(b) Moody, M. H.; Kaptein, B.; Broxterman, Q. B.; Boesten, W. H. J.; Kamphuis, J. Tetrahedron Lett. 1994, 35, 1777.
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 1777
-
-
Moody, M.H.1
Kaptein, B.2
Broxterman, Q.B.3
Boesten, W.H.J.4
Kamphuis, J.5
-
11
-
-
0027993912
-
-
(c)
-
(c) Sasai, H.; Kim, W.; Suzuki, T.; Shibasaki, M. Tetrahedron Lett. 1994, 35, 6123.
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 6123
-
-
Sasai, H.1
Kim, W.2
Suzuki, T.3
Shibasaki, M.4
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13
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1542499011
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2H, THF) followed by alkaline hydrolysis (2N KOH, EtOH, reflux). See: (a)
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2H, THF) followed by alkaline hydrolysis (2N KOH, EtOH, reflux). See: (a) Ito, Y.; Sawamura, M.; Hayahsi, T. Tetrahedron Lett. 1988, 29, 239.
-
(1988)
Tetrahedron Lett.
, vol.29
, pp. 239
-
-
Ito, Y.1
Sawamura, M.2
Hayahsi, T.3
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15
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0342541983
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(a) Chloramphenicol has been assigned as a generic name to the compound D-(-)-threo-N-(1,1′-dihydroxy-1-p-nitrophenylisopropyl)-dichloroacetamide for which Parke, Davis and Co. has adopted 'Chloromycetin' as its trademark
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(a) Chloramphenicol has been assigned as a generic name to the compound D-(-)-threo-N-(1,1′-dihydroxy-1-p-nitrophenylisopropyl)-dichloroacetamide for which Parke, Davis and Co. has adopted 'Chloromycetin' as its trademark.
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17
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0009128236
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(a)
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(a) Controulis, J.; Rebstock, M. C.; Crooks Jr., H. M. J. Am. Chem. Soc. 1949, 71, 2463.
-
(1949)
J. Am. Chem. Soc.
, vol.71
, pp. 2463
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-
Controulis, J.1
Rebstock, M.C.2
Crooks H.M., Jr.3
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19
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0030976217
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(c)
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(c) Hazra, B. G. et al. Syn. Comm. 1997, 27(11), 1857.
-
(1997)
Syn. Comm.
, vol.27
, Issue.11
, pp. 1857
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Hazra, B.G.1
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20
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0343847599
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(a) The absolute configuration was assumed from the results in Ref. 4 and confirmed later by comparison of the optical rotation with that reported for chloramphenicol (2)
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(a) The absolute configuration was assumed from the results in Ref. 4 and confirmed later by comparison of the optical rotation with that reported for chloramphenicol (2).
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21
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0342976309
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(b) The enantiomeric purity (ee) was determined by HPLC analysis using a Daicel Chiralcel OJ column
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(b) The enantiomeric purity (ee) was determined by HPLC analysis using a Daicel Chiralcel OJ column.
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22
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0342976307
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3 solution
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3 solution.
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23
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0343847598
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Keeping the reaction mixture at 40°C was crucial for good yields of the azide 6.
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Keeping the reaction mixture at 40°C was crucial for good yields of the azide 6.
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24
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37049097766
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Lambert, P. H.; Vaultier, M.; Carrie, R. J. Chem. Soc., Chem. Commun. 1982, 1224.
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(1982)
J. Chem. Soc., Chem. Commun.
, pp. 1224
-
-
Lambert, P.H.1
Vaultier, M.2
Carrie, R.3
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25
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0026023414
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Dolbier Jr., W. R.; Lee, S. K.; Phanstiel IV., O. Tetrahedron 1991, 47, 2065.
-
(1991)
Tetrahedron
, vol.47
, pp. 2065
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Dolbier W.R., Jr.1
Lee, S.K.2
Phanstiel, O.I.V.3
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26
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0343411601
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Kanfer, J. N.; Hakomori, S., Eds.; Plenum Press: New York
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Hakomori, S. Handbook of Lipid Research, Vol. 3, Sphingolipid Biochemistry; Kanfer, J. N.; Hakomori, S., Eds.; Plenum Press: New York, 1983; p. 6.
-
(1983)
Handbook of Lipid Research, Vol. 3, Sphingolipid Biochemistry
, pp. 6
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-
Hakomori, S.1
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28
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0027994895
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-
(b)
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(b) Byun, H.; Erukulla, R. K.; Bittman, R. J. Org. Chem. 1994, 59, 6495.
-
(1994)
J. Org. Chem.
, vol.59
, pp. 6495
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-
Byun, H.1
Erukulla, R.K.2
Bittman, R.3
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29
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0032925161
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-
(a)
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(a) Li, S.; Wilson, W. K.; Schroepfer Jr., G. J. J. Lipid Research 1999, 40, 117.
-
(1999)
J. Lipid Research
, vol.40
, pp. 117
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-
Li, S.1
Wilson, W.K.2
Schroepfer G.J., Jr.3
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30
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0033230998
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(b) 3175
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(b) Herdewijin, P.; De Jonghe, S.; Van Overmeire, I.; Gunst, J.; De Brunyn, A.; Hendrix, C.; Van Calenbergh, S.; Busson, R.; De Keukeleire, D.; Phillipe, J. Bioorg. Med. Chem. Lett. 1999, 9, 3159, 3175.
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 3159
-
-
Herdewijin, P.1
De Jonghe, S.2
Van Overmeire, I.3
Gunst, J.4
De Brunyn, A.5
Hendrix, C.6
Van Calenbergh, S.7
Busson, R.8
De Keukeleire, D.9
Phillipe, J.10
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31
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0033594158
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(c)
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(c) Kokotos, G. Pardrón, J. M.; Martin, V. S.; Hadjipavlou-Litina, D.; Noula, C.; Constantinou-Kokotou, V.; Peters, G. J. Bioorg. Med. Chem. Lett. 1999, 9, 821.
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 821
-
-
Kokotos, G.1
Pardrón, J.M.2
Martin, V.S.3
Hadjipavlou-Litina, D.4
Noula, C.5
Constantinou-Kokotou, V.6
Peters, G.J.7
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33
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0033611979
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(e)
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(e) He, L.; Byun, H.-P.; Smit, J.; Wilschut, J.; Bittman, R. J. Am. Chem. Soc. 1999, 121, 3897.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 3897
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He, L.1
Byun, H.-P.2
Smit, J.3
Wilschut, J.4
Bittman, R.5
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34
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0029112719
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(f)
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(f) Ruan, F.; Yamamura, S.; Hakomori, S.; Igarashi, Y. Tetrahedron Lett. 1995, 36, 6615.
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(1995)
Tetrahedron Lett.
, vol.36
, pp. 6615
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Ruan, F.1
Yamamura, S.2
Hakomori, S.3
Igarashi, Y.4
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35
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0342541979
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3 solution. The enantiomeric purity (ee) was determined later from its derivative because 10 is readily converted into the corresponding α,β-epoxy ester under basic conditions. The absolute configuration was assumed from the results in Ref. 4 and confirmed later by comparison of the optical rotation with that reported for the final product, acetyl (D)-threo-sphingosine
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3 solution. The enantiomeric purity (ee) was determined later from its derivative because 10 is readily converted into the corresponding α,β-epoxy ester under basic conditions. The absolute configuration was assumed from the results in Ref. 4 and confirmed later by comparison of the optical rotation with that reported for the final product, acetyl (D)-threo-sphingosine.
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36
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0342541980
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1H NMR analysis at 500 MHz. There was no detectable amount of the other enantiomer
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1H NMR analysis at 500 MHz. There was no detectable amount of the other enantiomer.
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38
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0342976304
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This research was assisted financially by a grant from the National Institutes of Health
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This research was assisted financially by a grant from the National Institutes of Health.
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