IL-9 protects mice from gram-negative bacterial shock: Suppression of TNF-α, IL-12, and IFN-γ, and induction of IL-10

Journal of Immunology

Volumn 164, Issue 8, 2000, Pages 4197-4203

  Grohmann, Ursula ^a   Van Snick, Jacques ^b   Campanile, Franca ^a   Silla, Silvia ^a   Giampietri, Antonio ^a   Vacca, Carmine ^a   Renauld, Jean Cristophe ^b   Fioretti, Maria C ^a   Puccetti, Paolo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 9; RECOMBINANT INTERLEUKIN 9; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFICACY; IMMUNE RESPONSE; IMMUNITY; IMMUNOMODULATION; IMMUNOREGULATION; INFECTION RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0034655243     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.8.4197     Document Type: Article

References (44)

1. Tracey, K. J., B. Beutler, S. F. Lowry, J. Merryweather, S. Wolpe, I. W. Milsark, R. J. Hariri, T. J. Fahey, A. Zentella, J. D. Albert, et al. 1986. Shock and tissue injury induced by recombinant human cachectin. Science 234:470.
2. Alexander, H. R., G, M. Doherty, C. M. Buresh, D. J. Venzon, and J. A. Norton. 1991. A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice. J. Exp. Med. 173:1029.
3. Doherty, G. M., J. R. Lange, H. N. Langstein, H. R. Alexander, C. M. Buresh, and J. A. Norton. 1992. Evidence for IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor α. J. Immunol. 149:1666.
4. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
5. Van Deuren, M., A. S. M. Dofferhoff, and J. W. M. van der Meer. 1992. Cytokines and the response to infection. J. Pathol. 168:349.
6. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
7. Murphy, E. E., G. Terres, S. E. Macatonia, C.-S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murhpy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and Interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
8. Kubiti, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211.
9. Beishuizen, A., I. Vermes, and C. Haanen. 1998. Endogenous mediators in sepsis and septic shock. Adv. Clin. Chem. 33:55.
10. Heurmann, D., M. P. Glauser, and T. Calandra. 1998. Monocyte deactivation in septic shock. Curr. Opin. Infect. Dis. 11:279.
11. Beutler, B., I. W. Milsarek, and A. C. Cerami. 1985. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229:689.
12. Heinzel, F. P. 1990. The role of IFN-γ in the pathology of experimental endotoxemia. J. Immunol. 145:2920.
13. Ohlsson, K., P. Bjork, M. Bergenfeld, R. Hageman, and R. C. Thompson. 1990. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348:550.
14. Bozza, M., A. R. Satoskar, G. Lin, B. Lu, A. A. Humbles, C. Gerard, and J. R. David. 1999. Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J. Exp. Med. 189:341.
15. Pfeffer, K., T. Matsuyama, T. M. Kundig, A. Wakeham, K. Kishihara, A. Shahinian, K. Wiegmann, P. M. Ohashi, M. Kronke, and T. W. Mak. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73:457.
16. Car, B. D., V. M. Eng, B. Schnyder, L. Ozmen, S. Huang, P, Gallay, D. Heumann, M. Aguet, and B. Riffel. 1994. Interferon γ receptor deficient mice are resistant to endotoxic shock. J. Exp. Med. 179:1437.
17. Marchant, A., C. Bruyns, P. Vandenabeele, M. Ducarme. C. Gerard, A. Delvaux, D. De Groote, D. Abramowicz, T. Velu, and M. Goldman. 1994. Interleukin-10 controls interferon-γ and tumor necrosis factor production during experimental endotoxemia. Eur. J. Immunol. 24:1167.
18. Howard, M., T. Muchamuel, S. Andrade, and S. Menon. 1993. Interleukin 10 protects mice from lethal endotoxemia. J. Exp. Med. 177:1205.
19. Gerard, C., C. Bruyns, A. Marchant, D. Abramowicz, P. Vandenabeele, A. Delvaux, W. Fiers, M. Goldman, and T. Velu. 1993. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med. 177:547.
20. Baumhofer, J. M., B. G. Beinhauer, J. E. Wang, H. Brandmeier, K. Geissler, E. Losert, R. Philip, G. Aversa, and M. G. Rogy. 1998. Gene transfer with IL-4 and IL-13 improves survival in lethal endotoxemia in the mouse and ameliorates peritoneal macrophages immune competence. Eur. J. Immunol. 28:610.
21. Jain-Vora, S., A. M. LeVine, Z. Chroneos, G. F. Ross, W. M. Hull, and J. A. Whitsett. 1998. Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. Infect. Immun. 66:4229.
22. Giampietri, A., U. Grohmann, C. Vacca, M. C. Fioretti, P. Puccetti, and F. Campanile. 2000. Dual effect of IL-4 on resistance to systemic Gram-negative infection and production of TNF-α. Cytokine. In press.
23. Muchamuel, T., S. Menon, P. Pisacane, M. C. Howerd, and D. A. Cockayne. 1997. IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia. J. Immunol. 158:2898.
24. Renauld, J.-C., F. Houssiau, J. Louahed, A. Vink, J. Van Snick, and C. Uyttenhove. 1993. Interleukin-9. Adv. Immunol. 54:79.
25. Demoulin, J. B., and J.-C. Renauld. 1998. Interleukin 9 and its receptor: an overview of structure and function. Int. Rev. Immunol. 16:345.
26. Kopf, M., G. Le Gros, M. Bachmann, M. C. Lamers, H. Bluethmann, and G. Köhler. 1993. Disruption of IL-4 gene blocks Th2 cytokine responses. Nature 362:245.
27. Gessner, A., H. Blum, and M. Röllinghoff. 1993. Differential regulation of IL-9 expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology 189:419.
28. Monteyne, P., J.-C. Renauld, J. Van Broeck, D. W. Dunne, F. Brombacher, and J.-P. Coutelier. 1997. IL-4-independent regulation of in vivo IL-9 expression. J. Immunol. 159:2616.
29. Grencis, R. K., L. Hultner, and K. J. Else. 1991. Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes. Immunology 74:329.
30. Svetic, A., K. B. Madden, X. Zhou, P. Lu, I. M. Katona, F. D. Finkelman, J. F. Urban, and W. C. Gause. 1993. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3. J. Immunol. 150:3434.
31. Faulkner, H., J.-C. Renauld, J. Van Snick, and R. K. Grencis. 1998. Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris. Infect. Immun. 66:3832.
32. Campanile, F., L. Binaglia, D. Boraschi, A. Tagliabue, M. C. Fioretti, and P. Puccetti. 1990. Antibacterial resistance induced by recombinant interleukin 1 in myelosuppressed mice: effect of treatment schedule and correlation with colony-stimulating activity in the bloodstream. Cell. Immunol. 128:250.
33. Campanile, F., A. Giampietri, U. Grohmann, L. Binaglia, M. C. Fioretti, and P. Puccetti. 1993. Protective effect of the cyclooxygenase inhibitor indomethacin against Pseudomonas aeruginosa infection in neutropenic mice. Cell Immunol. 147:341.
34. Campanile, F., A. Giampietri, U. Grohmann, M. L. Belladonna, M. C. Fioretti, and P. Puccetti. 1996. Evidence for tumor necrosis factor α as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis. Eur. J. Pharmacol. 307:191.
35. Druez, C., P. Coulie, C. Uyttenhove, and J. Van Snick. 1990. Functional and biochemical characterization of mouse P40/IL-9 receptors. J Immunol. 145:2494.
36. Fallarino, F., C. Uyttenhove, T. Boon, and T. F. Gajewski. 1996. Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo. J. Immunol. 156:1095.
37. Grohmann, U., R. Bianchi, E. Ayroldi, M. L. Belladonna, D. Surace, M. C. Fioretti, and P. Puccetti. 1997. A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state. J. Immunol. 158:3593.
38. Grohmann, U., R. Bianchi, M. L. Belladonna, C. Vacca, S. Silla, E. Ayroldi, M. C. Fioretti, and P. Puccetti. 1999. IL-12 acts selectively on CD8α dendritic cells to enhance presentation of a tumor peptide in vivo. J. Immunol. 163:3100.
39. Houssiau, F. A., L. Schandené, M. Stevens, C. Cambiaso, M. Goldman, J. Van Snick, and J. C. Renauld. 1995. A cascade of cytokines is responsible for IL-9 expression in human T cells. J. Immunol. 154:2624.
40. Else, K. J., L. Hultner, and R. K. Grencis. 1992. Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of Th-cell subsets in resistant versus susceptible mice. Immunology 75:232.
41. Petit-Frere, C., B. Dugas, P. Braquet, and J. M. Mencia-Huerta. 1993. Interleukin-9 potentiates the interleukin-4-induced IgE and IgGI release from murine B lymphocytes. Immunology 79:146.
42. Louahed, J., A. Kermouni, J. Van Snick, and J.-C. Renauld. 1995. IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones. J. Immunol. 154:5061.
43. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra, 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147: 3815.
44. Howard, M., A. O'Garra, H. Ishida, R. de Waal Malefyt, and J. De Vries. 1992. Biological properties of interleukin 10. J. Clin. Immunol. 12:239.