Determination of harmane and harmine in human blood using reversed- phased high-performance liquid chromatography and fluorescence detection

Analytical Biochemistry

Volumn 279, Issue 2, 2000, Pages 125-129

  Zheng, Wei ^a   Wang, Shunzhen ^a   Barnes, Livia F ^b   Guan, Yongbiao ^a   Louis, Elan D ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINITY; ALKALOIDS; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHANOL; NUTRITION; ORGANIC SOLVENTS; POTASSIUM COMPOUNDS;

ALKALINE CONDITIONS; ANALYTICAL METHOD; CARBOLINE DERIVATIVES; DETECTION LIMITS; FLUORESCENCE DETECTION; METHYL-T-BUTYL ETHERS; POTASSIUM PHOSPHATE; REVERSED-PHASE COLUMNS;

BLOOD;

HARMAN; HARMINE;

ANALYTIC METHOD; ARTICLE; BLOOD CHEMISTRY; BLOOD LEVEL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ESSENTIAL TREMOR; FLUORESCENCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

EID: 0034654579     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1999.4456     Document Type: Article

References (10)

1. Adachi J., Mizoi Y., Naito T., Yamamoto K., Fujiwara S., Ninomiya I. Determination of β-carbolines in foodstuffs by high performance liquid chromatography and high performance liquid chromatograph-mass spectrometry. J. Chromatogr. 538:1991;331-339.
2. Allen R. F., Beck O., Borg S., Skroder R. Analysis of 1-methyl-1,2,3,4-tetrahydro-β-carboline in human urine and cerebrospinal fluid by gas chromatography-mass spectrometry. Eur. J. Mass Spectrom. 1:1980;171-177.
3. Bidder T. A., Shoemaker D. W., Boettger H. G., Evans M., Cummins J. T. Harmane in human platelets. Life Sci. 25:1979;157-164.
4. Moncrieff J. Determination of pharmacological levels of harmane, harmine and harmaline in mammalian brain tissue, cerebrospinal fluid and plasma by high-performance liquid chromatography with fluorimetric detection. J. Chromatogr. 496:1989;269-278.
5. O'Hearn E., Molliver M. E. The olivocerebellar projection mediates ibogaine induced degeneration of Purkinje cells: A model of indirect, trans-synaptic excitotoxicity. J. Neurosci. 17:1997;8828-8841.
6. Poindexter E. H., Carpenter R. D. The isolation of harmane and norharmane from tobacco and cigarette smoke. Phytochemistry. 1:1962;215-221.
7. Ren S., Scheuer M. L., Zheng W. Determination of lamotrigine in biological materials by a simple and rapid liquid chromatographic method. Ther. Drug Monitor. 20:1998;209-214.
8. Rommelspacher H., Strauss S., Lindemann J. Excretion of tetrahydroharmane and harmane into the urine of man and rat after load with ethanol. FEBS Lett. 109:1980;209-212.
9. Rommelspacher H., Barbey M., Strauss S., Greiner B., Fahndrich E. Bloom F., Barchas J., Sandler M., Usdin E. Beta-Carbolines and Tetrahydroisoquinolines. 1982;41-55 A. R. Liss, New York.
10. Zetler G., Singbartl G., Schlosser L. Cerebral pharmacokinetics of tremor-producing harmala and iboga alkaloids. Pharmacology. 7:1972;237-248.