A region containing a proline-rich motif targets sG(i2) to the Golgi apparatus

Experimental Cell Research

Volumn 255, Issue 2, 2000, Pages 258-269

  Picetti, Roberto ^a   Borrelli, Emiliana ^a  

^a INSERM   (France)

Author keywords

Cultured cells; G proteins; Golgi apparatus; Immunocytochemistry; Targeting sequence

Indexed keywords

BREFELDIN A; CHLOROQUINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034654274     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4783     Document Type: Article

References (43)

1. Neer E. J. Heterotrimeric G proteins: Organizers of transmembrane signals. Cell. 80:1995;249-257.
2. Sternweis P. C. The active role of beta gamma in signal transduction. Curr. Opin. Cell Biol. 6:1994;198-203.
3. Bomsel M., Mostov K. Role of heterotrimeric G proteins in membrane traffic. Mol. Biol. Cell. 3:1992;1317-1328.
4. Helms J. B. Role of heterotrimeric GTP binding proteins in vesicular protein transport: Indications for both classical and alternative G protein cycles. FEBS Lett. 369:1995;84-88.
5. Helms J. B., Helms-Brons D., Brugger B., Gkantiragas I., Eberle H., Nickel W., Nurnberg B., Gerdes H. H., Wieland F. T. A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J. Biol. Chem. 273:1998;15203-15208.
6. Leyte A., Barr F. A., Kehlenbach R. H., Huttner W. B. Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation. EMBO J. 11:1992;4795-4804.
7. Pimplikar S. W., Simons K. Regulation of apical transport in epithelial cells by a Gs class of heterotrimeric G protein. Nature. 362:1993;456-458.
8. Denker S. P., McCaffery J. M., Palade G. E., Insel P. A., Farquhar M. G. Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. J. Cell Biol. 133:1996;1027-1040.
9. Ahnert-Hilger G., Schafer T., Spicher K., Grund C., Schultz G., Wiedenmann B. Detection of G-protein heterotrimers on large dense core and small synaptic vesicles of neuroendocrine and neuronal cells. Eur. J. Cell Biol. 65:1994;26-38.
10. Ahnert-Hilger G., Nurnberg B., Exner T., Schafer T., Jahn R. The heterotrimeric G protein Go2 regulates catecholamine uptake by secretory vesicles. EMBO J. 17:1998;406-413.
11. Jamora C., Takizawa P. A., Zaarour R. F., Denesvre C., Faulkner D. J., Malhotra V. Regulation of Golgi structure through heterotrimeric G proteins. Cell. 91:1997;617-626.
12. Yamaguchi T., Yamamoto A., Furuno A., Hatsuzawa K., Tani K., Himeno M., Tagaya M. Possible involvement of heterotrimeric G proteins in the organization of the Golgi apparatus. J. Biol. Chem. 272:1997;25260-25266.
13. Montmayeur J. P., Borrelli E. Targeting of G alpha i2 to the Golgi by alternative spliced carboxyl-terminal region. Science. 263:1994;95-98.
14. Maier O., Ehmsen E., Westermann P. Trimeric G protein alpha subunits of the Gs and Gi families localized at the Golgi membrane. Biochem. Biophys. Res. Commun. 208:1995;135-143.
15. Kehlenbach R. H., Matthey J., Huttner W. B. XL alpha s is a new type of G protein. Nature. 372:1994;804-809.
16. Casey P. J. Lipid modifications of G proteins. Curr. Opin. Cell Biol. 6:1994;219-225.
17. Mumby S. M. Reversible palmitoylation of signaling proteins. Curr. Opin. Cell Biol. 9:1997;148-154.
18. Munro S. Localization of proteins to the Golgi apparatus. Trends Cell Biol. 8:1998;11-15.
19. Machamer C. E. Targeting and retention of Golgi membrane proteins. Curr. Opin. Cell Biol. 5:1993;606-612.
20. Mellman I. Endocytosis and molecular sorting. Annu. Rev. Cell Dev. Biol. 12:1996;575-625.
21. Ali S., Lutz Y., Bellocq J. P., Chenard-Neu M. P., Rouyer N., Metzger D. Production and characterization of monoclonal antibodies recognising defined regions of the human oestrogen receptor. Hybridoma. 12:1993;391-405.
22. Samad T. A., Krezel W., Chambon P., Borrelli E. Regulation of dopaminergic pathways by retinoids: Activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family. Proc. Natl. Acad. Sci. USA. 94:1997;14349-14354.
23. Higuchi R. Recombinant PCR. Innis M A., Gelfand D. H., Sninsky J. J., White T. J. PCR Protocols. 1990;Academic Press, San Diego.
24. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
25. Klausner R. D., Donaldson J. G., Lippincott-Schwartz J. Brefeldin A: Insights into the control of membrane traffic and organelle structure. J. Cell Biol. 116:1992;1071-1080.
26. Velasco A., Hendricks L., Moremen K. W., Tulsiani D. R., Touster O., Farquhar M. G. Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II. J. Cell Biol. 122:1993;39-51.
27. Wilson B. S., Nuoffer C., Meinkoth J. L., McCaffery M., Feramisco J. R., Balch W. E., Farquhar M. G. A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus. J. Cell Biol. 125:1994;557-571.
28. Wong Y. H., Federman A., Pace A. M., Zachary I., Evans T., Pouyssegur J., Bourne H. R. Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature. 351:1991;63-65.
29. Trowbridge I. S., Collawn J. F., Hopkins C. R. Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell Biol. 9:1993;129-161.
30. Chapman R. E., Munro S. Retrieval of TGN proteins from the cell surface requires endosomal acidification. EMBO J. 13:1994;2305-2312.
31. Zerial M., Stenmark H. Rab GTPases in vesicular transport. Curr. Opin. Cell Biol. 5:1993;613-620.
32. Wedegaertner P. B., Bourne H. R. Activation and depalmitoylation of Gs alpha. Cell. 77:1994;1063-1070.
33. Chavrier P., Gorvel J. P., Stelzer E., Simons K., Gruenberg J., Zerial M. Hypervariable C-terminal domain of rab proteins acts as a targeting signal. Nature. 353:1991;769-772.
34. Conklin B. R., Farfel Z., Lustig K. D., Julius D., Bourne H. R. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 363:1993;274-276.
35. Conklin B. R., Bourne H. R. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell. 73:1993;631-641.
36. de Almeida J. B., Holtzman E. J., Peters P., Ercolani L., Ausiello D. A., Stow J. L. Targeting of chimeric G alpha i proteins to specific membrane domains. J. Cell Sci. 107:1994;507-515.
37. Ylikomi T., Bocquel M. T., Berry M., Gronemeyer H., Chambon P. Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors. EMBO J. 11:1992;3681-3694.
38. Jones D. T., Reed R. R. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J. Biol. Chem. 262:1987;14241-14249.
39. Garnier J., Gibrat J. F., Robson B. GOR method for predicting protein secondary structure from amino acid sequence. Methods Enzymol. 266:1996;540-553.
40. Yu H., Chen J. K., Feng S., Dalgarno D. C., Brauer A. W., Schreiber S. L. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell. 76:1994;933-945.
41. Berlot C. H., Bourne H. R. Identification of effector-activating residues of Gs alpha. Cell. 68:1992;911-922.
42. Lambright D. G., Sondek J., Bohm A., Skiba N. P., Hamm H. E., Sigler P. B. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 379:1996;311-319.
43. Bar-Sagi D., Rotin D., Batzer A., Mandiyan V., Schlessinger J. SH3 domains direct cellular localization of signaling molecules. Cell. 74:1993;83-91.