Orally administrated cerium chloride induces the conformational changes of rat hemoglobin, the hydrolysis of 2,3-DPG and the oxidation of heme-Fe(II), leading to changes of oxygen affinity

Chemico-Biological Interactions

Volumn 125, Issue 3, 2000, Pages 191-208

  Cheng, Yi ^a   Li, You ^a   Li, Rongchang ^a   Lu, Jingfen ^a   Wang, Kui ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

2,3 DPG; Cerium chloride; Conformational change; Hemoglobin; Oxygen affinity

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; CERIUM; CERIUM CHLORIDE; FERROUS ION; HEME; HEMOGLOBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ERYTHROCYTE; INFRARED SPECTROPHOTOMETRY; MALE; MOSSBAUER SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN AFFINITY; PROTEIN STRUCTURE; RAT;

2,3-DIPHOSPHOGLYCERATE; ADMINISTRATION, ORAL; ANIMALS; CERIUM; ERYTHROCYTES; FERROUS COMPOUNDS; HEME; HEMOGLOBINS; HYDROGEN PEROXIDE; HYDROLYSIS; MALE; OXIDATION-REDUCTION; OXYGEN; PROTEIN CONFORMATION; RATS; RATS, WISTAR;

RATTUS NORVEGICUS; SIGMOIDEA;

EID: 0034653890     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00146-0     Document Type: Article

References (47)

1. Evans C.H. Biochemistry of the Lanthanides. 1990;339-389 Plenum Press, New York.
2. Ni J.Z. Bioinorganic Chemistry of Rare Earth Elements. 1995;13-59 Science Press, Beijing.
3. Hirano S., Suzuki K.T. Exposure, metabolism, and toxicity of rare earths and related compounds. Environ. Health Perspec. 104:1996;85-95.
4. Fischler F., Roeckl K.W. Über experimentelle Boerinflussung er Leberfunktionen und der anatomischen Leberstrukfur durch Einwirking seltaer Erden Arch. Exp. Pathol. Pharmacol. 189:1938;4-21.
5. Haley T.J. Toxicity. Gschneidner K.A., Eyring L. Handbook on the Physics and Chemistry of Rare Earths. 1979;553-585 North-Holland Publishing Company, Holland.
6. Beaser S.B., Segel A., Vandam L. Anticoagulant effects in rabbits and man of the intravenous injection of salts of the rare earths. J. Clin. Invest. 21:1942;447-453.
7. Hunter R.B., Walker W. Anticoagulant action of neodymium 3-sulpho-isonicotinate. Nature. 178:1956;47.
8. Majumdar S., Baker R.F., Kalra V.K. Fusion of human erythrocytes induced by uranyl acetate and rare earth-metals. Biochim. Biophys. Acta. 598:1980;411-416.
9. Cheng Y., Yao H.Y., Lin H.K., Lu J.F., Li R.C., Wang K. The events relating to lanthanide ions enhanced permeability of human erythrocyte membrane: binding, conformational change, phase transition, perforation and ion transport. Chem.-Biol. Interact. 121:1999;267-289.
10. Cheng Y., Liu M.Z., Li R.C., Wang C., Bai C.L., Wang K. Gadolinium induces domain and pore formation of human erythrocyte membrane: an atomic force microscopic study. Biochim. Biophys. Acta. 1421:1999;249-260.
11. Cheng Y., Chen B.W., Lu J.F., Wang K. The reaction of lanthanide ions with n-doxyl stearic acids and its utilization for the ESR study on the permeability of lipid-bilayer of erythrocyte membrane to gadolinium ions. J. Inorg. Biochem. 69:1998;1-7.
12. Cheng Y., Huo Q.H., Lu J.F., Li R.C., Wang K. The transport kinetics of lanthanide species in single erythrocyte probed by confocal laser scanning microscopy. J. Biol. Inorg. Chem. 4:1999;447-456.
13. 3 feeding rats. Prog. Nat. Sci. 9:1999;610-616.
14. 3 per os. Chin. Sci. Bull. 44:1999;1520-1523.
15. Cheng Y, Li Y., Yao H.Y., Li R.C., Wang K. Mechanism of Gadolinium anion complex enter into human erythrocyte and its influence on chlorine ion influx. J. Chin. Rare Earth Soc. 17:1999;54-59.
16. Feng J., Bo Y., Yang X., Wang K., Gao S. Investigation of interaction of lanthanides with hemoglobin and effect on oxygen-carrier function. J. Rare Earths. 16:1998;139-144.
17. Simmons A. Technical Hematology. 1976;9-12 J.B.Lippincott Company Press, Hagerstown.
18. Riggs A. Preparation of blood hemoglobins of vertebrates. Antonini E., Rossi-Bernardi L., Chiancone E. Methods in Enzymology. 1981;5-14 Academic press, New York.
19. Benesch R., Macduff G., Benesch R.E. Determination of oxygen equilibria with a versatile new tonometer. Anal. Biochem. 11:1965;81-87.
20. Dong A., Huang P., Caughey W.S. Protein secondary structures in water from second-derivative amide I infrared spectra. Biochemistry. 29:1990;3303-3308.
21. Gonser U., Grant R.W. Mössbauer effect in hemoglobin and some iron-containing biological compounds. Biophys. J. 5:1965;823-845.
22. Bauminger E.R., Cohen S.G., Ofer S., Rachmilewitz E.A. Quantitative studies of ferritinlike iron in erythrocytes of thalassemia, sickle-cell anemia and hemoglobin hammersmith with Mössbauer spectroscopy, proc. Natl. Acad. Sci. USA. 76:1979;939-943.
23. Ofer S., Fibach E., Kessel M., Bauminger E.R., Cohen S.G., Eikelboom J., Rachmilewitz E.A. Iron incorporation into ferritin and hemoglobin during differentiation of murine erythroleukemia cells. Blood. 58:1981;255-262.
24. Kent T.A., Young L.J., Palmer G., Fee J.A., Münck E. Mössbauer study of beef heart cytochrome oxidase. J. Biol. Chem. 258:1983;8543-8546.
25. Peisach J., Blumberg W.E., Ogawa S., Rachmilewitz E.A., Oltzik R. The effects of protein conformation on the heme symmetry in high spin ferric heme proteins as studies by electron paramagnetic resonance. J. Biol. Chem. 246:1971;3342-3355.
26. Maltempo M.M., Moss T.H., Cusanovich M.A. Magnetic studies on the changes in the iron environment in chromatium ferricytochrome C. Biochim. Biophys. Acta. 342:1974;290-305.
27. 4. Inorg. Chem. 28:1989;1591-1595.
28. Geraci G., Parkhurst L.J. Circular dichroism spectra of hemoglobin. Antonini E., Rossi-Bernardi L., Chiancone E. Methods in Enzymology. 1981;262-275 Academic Press, New York.
29. Byler D.M., Susi H. Examination of the secondary structure of proteins by deconvolved FTIR spectra. Biopolymers. 25:1986;469-487.
30. Schlereth D.D., Mäntele W. Redox-induced conformational changes in myoglobin and hemoglobin: electrochemistry and ultraviolet-visible and Fourier transform infrared difference spectroscopy at surface-modified gold electrodes in an ultra-thin-layer spectroelectrochemical cell. Biochemistry. 31:1992;7494-7502.
31. 31P nuclear magnetic resonance spectroscopy. Biochim. Biophys. Acta. 490:1977;290-300.
32. 31P magnetic resonance. J. Biol. Chem. 248:1973;7276-7278.
33. North J.A., Spector A.A., Buettner G.R. Detection of lipid radicals by electron paramagnetic resonance spin trapping using intact cells enriched with polyunsaturated fatty acid. J. Biol. Chem. 267:1992;5743-5746.
34. Aime S., Fasano M., Paoletti S., Bellelli A., Coletta M., Ascenzi P. Stabilization of the T-state of ferrous human adult and fetal hemoglobin by Ln(III) complexes: a thermodynamic study. J. Inorg. Biochem. 71:1998;37-43.
35. Winslow R.M., Swenberg M.L., Berger R.L., Shrager R.I., Luzzana M., Samaja M., Rossi-Bernardi L. Oxygen equilibrium curve of normal human blood and its evaluation by Adair's equation. J. Biol. Chem. 252:1977;2331-2337.
36. Imai K. Adair Fitting to oxygen equilibrium curves of hemoglobin. Methods in Enzymology. 1994;Academic Press, NY.
37. Lindstrom T.R., Ho C. Functional nonequivalence of α and β Hemes in human adult hemoglobin. Proc. Nat. Acad. Sci. USA. 69:1972;1707-1710.
38. Cheng Y, Yang XD, Chen BW et al. In: Applied Scientific Research of the Netherland et al. Cellular uptake and response to lanthanides. Proceedings of the second Sino -Dutch workshop on the environmental behaviour and ecotoxicology of REEs and heavy metals. Energy Research press, Delft, (1997), pp.1-13.
39. Benesch R., Benesch R.E. The effect of organic phosphates from human erythrocyte on the allosteric properties of hemoglobin. Biochem. Biophys. Res. Commun. 26:1967;162-167.
40. Arnone A. X-ray diffraction study of binding of 2,3-diphosphoglycerate to human deoxyhemoglobin. Nature. 237:1972;146-149.
41. Lennon A.J., Scott N.R., Chapman B.E., Kuchel P.W. Hemoglobin affinity for 2,3-bisphosphoglycerate in solutions and intact erythrocytes: studies using pulsed-field gradient nuclear magnetic resonance and monte carlo simulations. Biophys. J. 67:1994;2096-2109.
42. Benesch R., Benesch R.E., Yu C.I. Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin. Proc. Nat. Acad. Soc. 59:1968;526-532.
43. Tyuma I., Imai K., Shimizu K. Analysis of oxygen equilibrium of hemoglobin and control mechanism of organic phosphates. Biochemistry. 12:1973;1491-1498.
44. Komiyama M. Sequence-specific and hydrolytic scission of DNA and RNA by lanthanide complex-oligoDNA hybrids. J. Biochem. 118:1995;665-670.
45. Matsumura K., Komiyama M. Hydrolysis of phosphatidylinositol by rare earth metal ion as a phospholipase C mimic. J. Inorg. Biochem. 55:1994;153-156.
46. Chin J., Takasaki B.K. Synergistic effect between La(III) and hydrogen peroxide in phosphate diester cleavage. J. Am. Chem. Soc. 115:1993;9337-9338.
47. Hurst P., Takasaki B.K., Chin J. Rapid cleavage of RNA with a La(III) dimer. J. Am. Chem. Soc. 118:1996;9982-9983.