Synthesis of carbon-14 labelled (3-{[(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indol-1-yle]carbonylamino}propyl)trimethylammonium chloride, a potential cartilage-targeted antirheumatic drug

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 43, Issue 3, 2000, Pages 297-308

  Giraud, Isabelle ^a   Rapp, Maryse ^a   Dupuy, Jean Michel ^a   Maurizis, Jean Claude ^a   Madelmont, Jean Claude ^a  

^a INSERM   (France)

Author keywords

Antirheumatic drug; Carbon 14; Cartilage targeting; Quaternary ammonium; Tenidap

Indexed keywords

BARIUM COMPOUNDS; CARBON; CHLORINE COMPOUNDS;

ANTIRHEUMATIC DRUG; CARBON 14; CARBOXAMIDES; CARTILAGE TARGETING; PHARMACOKINETIC STUDIES; QUATERNARY AMMONIUM; STEP SEQUENCES; SYNTHESISED; TENIDAP; [CARBONYL;

CARTILAGE;

ANTIRHEUMATIC AGENT; BARIUM DERIVATIVE; CARBON 14; QUATERNARY AMMONIUM DERIVATIVE; TRIMETHYLAMMONIUM SALT DERIVATIVE;

ARTICLE; DRUG SPECIFICITY; DRUG SYNTHESIS; ISOTOPE LABELING;

EID: 0034653191     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-1344(20000315)43:3<297::aid-jlcr317>3.0.co;2-%23     Document Type: Article

References (14)

1. Katz P., Borger A.P. and Loose L.D. Arthritis Rheum. 31: 52 (1988).
2. Davis J.S., Loose L.D. and Borger A.P. Arthritis Rheum. 31: 72 (1988).
3. Kraska A.R., Wilhem F.E., Kirby D.S., Loose L.D., Ting N., Shanahan W.R. and Weiner E.S. Arthritis Rheum. 36: S57 (1993).
4. Leeming M.R.G. Arthritis Rheum. 36: S111 (1993).
5. Sipe J.D., Barthle L.M. and Loose L.D. J. Immunol. 148: 480 (1992).
6. McNiff P.A., Laliberte R., Svensson L., Pazoles J. and Gabel C.A. Cytokine. 7: 196-208 (1995).
7. Choy E.H.S. and Scott D.L. Drugs. 53: 337-348 (1997).
8. Garrigue H., Maurizis J.-C., Nicolas C., Madelmont J.-C., Godeneche D., Hulot T., Morge X., Demerseman P., Sentenac-Roumanou H. and Veyre A. Xenobiotica. 20: 699-709 (1990).
9. Garrigue H., Maurizis J.-C., Madelmont J.-C., Nicolas C., Meyniel J.-M., Louvel A., Demerseman P., Sentenac-Roumanou H. and Veyre A. Xenobiotica. 21: 583-595 (1991).
10. Maurizis J.-C, Ollier M., Nicolas C., Madelmont J.-C., Garrigue H. and Veyre A. Biochem. Pharmacol. 44: 1927-1933 (1992).
11. Madelmont J.-C., Giraud I., Nicolas C., Maurizis J.-C., Rapp M. , Ollier M., Renard P. and Caignard D.-H. French patent 99,08020 (1999).
12. Rusek F. W., Falkner F.C., Johnson D.L., Robinson R.P. and Melvin L.S., J. Labelled Compd. Rad. 35:207-214 (1996).
13. Fouda H.G., Avery M.J., Dalvie D., Falkner F.C., Melvin L.S. and Ronfeld R.A. Drug Metab. Dispos. 25: 140-148 (1997).
14. Pichat L. and Carbonnier P. CEA Report no 1148 (1959).