Fast track - Critical and optimal ig domains for promotion of neurite outgrowth by L1/Ng-CAM

Journal of Neurobiology

Volumn 42, Issue 3, 2000, Pages 287-302

  Haspel, Jeffrey ^a   Friedlander, David R ^a   Ivgy May, Neely ^a   Chickramane, Sucheta ^a   Roonprapunt, Chan ^a   Chen, Suzhen ^a   Schachner, Melitta ^a   Grumet, Martin ^a,b,c  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Cell adhesion molecules; Ig superfamily; Nerve regeneration

Indexed keywords

AMINO ACID; IMMUNOGLOBULIN G; NERVE CELL ADHESION MOLECULE;

AMINO ACID SEQUENCE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; GROWTH STIMULATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NERVE CELL; NERVE FIBER GROWTH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMAL; CELL ADHESION; CELL LINE; HUMAN; LEUKOCYTE L1 ANTIGEN COMPLEX; MAMMALS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; NEURAL CELL ADHESION MOLECULES; NEURITES; NEURONS; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; TRANSFECTION;

EID: 0034651667     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4695(20000215)42:3<287::aid-neu1>3.0.co;2-x     Document Type: Article

References (51)

1. Appel F, Holm J, Conscience JF, Schachner M. 1993. Several extracellular domains of the neural cell adhesion molecule LI are involved in neurite outgrowth and cell body adhesion. J Neurosci 13:4764-4775.
2. Aubert I, Ridet JL, Schachner M, Rougon G, Gage FH. 1998. Expression of LI and PSA during sprouting and regeneration in the adult hippocampal formation. J Comp Neural 399:1-19.
3. Bateman A, Jouet M, MacFarlane J, Du JS, Kenwrick S, Chothia C. 1996. Outline structure of the human LI cell adhesion molecule and the sites where mutations cause neurological disorders. EMBO J 15:6050-6059.
4. Brewer GJ. 1995. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res 42:674-683.
5. Brummendorf T, Rathjen FG. 1995. Cell adhesion molecules 1: Immunoglobulin superfamily, Vol. 2. London: Academic Press.
6. Brummendorf T, Rathjen FG. 1996. Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily. Curr Opin Neurobiol 6:584-93.
7. Burgoon MP, Grumet M, Mauro V, Edelman GM, Cunningham BA. 1991. Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of polypeptides and relation to Ig superfamily. J Cell Biol 112:1017-1029.
8. Burgoon MP, Kazan R, Phillips GR, Crossin KL, Edelman GM, Cunningham BA. 1995. Functional analysis of posttranslational cleavage products of the neuron-glia cell adhesion molecule, Ng-CAM. J Cell Biol 130:733-744.
9. Buchstaller A, Kunz S, Berger P, Kunz B, Ziegler U, Rader C, Sonderegger P. 1996. Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion. JCell Biol 135:1593-1607.
10. Chamow SM, Ashkenazi A. 1996. Immunoadhesins: principles and applications. Trends Biotechnol 14:52-60.
11. Chang S, Rathjen FG, Raper JA. 1987. Extension of neurites on axons is impaired by antibodies against specific neural cell surface glycoproteins. J Cell Biol 104:355-362.
12. Chen S, Mantei N, Dong L, Nienaber, Haspel J, Grumet M, Schachner M. 1999a. Identification of domains of the neural cell adhesion molecule LI involved in neuronal survival, cerebellar cell neurite outgrowth and fasciculation. Mauscript in preparation.
13. Chen S, Mantei N, Dong L, Schachner M. 1999b. Prevention of neuronal cell death by neural adhesion molecules LI and CHL1. J Neurobiol 38:428-439.
14. Cohen NR, Tayior JSH, Scott LB, Guillery RW, Soriano P, Furley AJW. 1997. Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule LI. Curr Biol 8:26-33.
15. Chickramane S, Friedlander DR, Grumet M. 1996. Recombinant fragments of Ng-CAM with different effects on CNS and PNS neurite outgrowth. Soc Neurosci Abstr 22:1465 (Abstract).
16. De Angelis E, MacFarlane J, Jian-Sheng D, Yeo G, Hicks R, Rathjen FG, Kenwrick S, Brummendorf T. 1999. Pathological missense mutations of neural cell adhesion molecule LI affect homophilic and heterophilic binding activities. EMBO J 18:4744-4753.
17. Doherty P, Williams E, Walsh FS. 1995. A soluble chimeric form of the LI glycoprotein stimulates neurite outgrowth. Neuron 14:57-66.
18. Fischer G, Kunemund V, Schachner M. 1986. Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein LI. J Neurosci 6:605-612.
19. Friedlander DR, Milev P, Karthikeyan L, Margolis RK, Margolis RU, Grumet M. 1994. The neuronal chondroitin sulfate proteoglycan neurocan binds to neural adhesion molecules Ng-CAM/Ll/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J Cell Biol 125:669-680.
20. Friedlander DR, Brittis P, Sakurai T, Shif B, Wirchansky W, Fishell G, Grumet M. 1998. Generation of a radiallike glial cell line. J Neurobiol 37:291-304.
21. Grumet M. 1992. Structure, expression, and function of Ng-CAM, a member of the immunoglobulin superfamily involved in neuron-neuron and neuron-glia adhesion. J Neurosci Res 31:1-13.
22. Grumet M, Sakurai T. 1996. Heterophilic interactions of the cell adhesion molecules Ng-CAM and Nr-CAM with neural receptors and extracellular matrix proteins. Semin Neurosci 8:379-389.
23. Grumet M, Edelman GM. 1988. Neuron-glia cell adhesion molecule interacts with neurons and astroglia via different binding mechanisms. J Cell Biol 106:487-503.
24. Haspel J, Friedlander DR, Blanco C, Badrian C, Younger C, Grumet M. 1999. Functional mapping of LI-CAM using recombinant Fc fusion proteins. Soc Neurosci Abstr 25:8 (Abstract).
25. Hortsch M. 1996. The LI family of neural cell adhesion molecules: old proteins performing new tricks. Cell 17: 587-593.
26. Hortsch M, O'Shea KS, Zhao G, Kirn F, Vallejo Y, Dubreuil RR. 1998. A conserved role for LI as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly. Cell Adhes Commun 5:6173.
27. Huang W, Roonprapunt C, Gril R, Grumet M, Young W. 1999. Cell adhesion molecule LI therapy of spinal cord injury. Soc Neurosci Abstr 25:492 (Abstract).
28. Jung M, Petrausch B, Stuermer CAO. 1997. Axon-regenerating retinal ganglion cells in adult rats synthesize the cell adhesion molecule LI but not TAG-1 or SC-1. Mol Cell Neurosci 9:116-131.
29. Kamiguchi H, Lemmon V. 1997. Neural cell adhesion molecule LI: signaling pathways and growth cone motility. J Neurosci Res 49:1-8.
30. Karagogeos D, Morton SB, Casano F, Dodd J, Jessell TM. 1991. Developmental expression of the axonal glycoprotein TAG-1: differential regulation by central and peripheral neurons in vitro. Development 112:51-67.
31. Kenwrick S, Doherty P. 1998. Neural cell adhesion molecule LI: relating disease to function. Bioessays 20:1-9.
32. Kunz S, Spirig M, Ginsburg C, Buchstaller A, Berger P, Lanz R, Rader C, Vogt L, Kunz B, Sonderegger P. 1998. Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule. J Cell Biol 143:1673-1690.
33. Lagenaur C, Lemmon V. 1987. An Ll-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc Natl Acad Sci USA 84:7753-7757.
34. Lemmon V, Fair KL, Lagenaur C. 1989. Ll-mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron 2:1597-1603.
35. Martini R, Schachner M. 1988. Immunoelectron microscopic localization of neural cell adhesion molecules (LI, N-CAM and myelin associated glycoprotein) in regenerating adult mouse sciatic nerve. J Cell Biol 106:1735-1746.
36. Martini R. 1994. Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves. J Neurocytol 23:1-28.
37. Mohajeri MH, Bartsch U, van der Putten H, Sansig G, Mucke L, Schachner M. 1996. Neurite outgrowth on non-permissive substrates in vitro is enhanced by ectopic expression of the neural adhesion molecule LI by mouse astrocytes. Eur J Neurosci 8:1085-1097.
38. Moos M, Tacke R, Scherer H, Teplow D, Früh K, Schachner M. 1988. Neural adhesion molecule LI as a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Nature 334:701-703.
39. Nieke J, Schachner M. 1985. Expression of the neural cell adhesion molecules LI and N-CAM and their common carbohydrate epitope L2/HNK-1 during development and after transaction of the mouse sciatic nerve. Differentiation 30:141-151.
40. Rathjen FG, Wolff JM, Frank R, BonhoefferF, Rutishauser U. 1987. Membrane glycoproteins involved in neunte fasciculation. J Cell Biol 104:343-353.
41. Roonprapunt C, Hooper A, Huang W, Friedlander DR, Grumet M, Young W. 1996. Elevated levels of the cell adhesion molecule, LI, following spinal cord injury in the adult rat. Soc Neurosci Abstr 22:1018 (Abstract).
42. Sakurai T, Roonprapunt C, Grumet M. 1998. Purification of Ig-fusion proteins from medium containing Ig. Biotechniques 25:382-384.
43. Salton SRJ, Richter-Landsberg C, Greene LA, Shelanski ML. 1983. Nerve growth factor-inducible large external (NILE) glycoprotein: studies of a central and peripheral neuronal marker. J Neurosci 3:441-454.
44. Schachner M, Martini R. Glycans and the modulation of neural-recognition molecules function. 1995. Trends Neurosci 18:183-191.
45. Su XD, Gastinel LN, Vaughn D, Faye I, Poon P, Bjorkman PJ. 1998. Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion. Science 281: 991-995.
46. Williams EJ, Doherty P, Turner G, Reid RA, Hemperly JJ, Walsh FS. 1992. Calcium influx into neurons can solely account for cell contact-dependent neurite outgrowth stimulated by transfected LI. J Cell Biol 119: 883-892.
47. Wong EV, Kenwrick S, Willems P, Lemmon V. 1995. Mutations in the cell adhesion molecule LI cause mental retardation. Trends Neural Sci 18:168-172.
48. Yip PM, Zhao X, Montgomery AMP, Siu C. 1998. The Arg-Gly-Asp Motif in the cell adhesion molecule LI promotes neurite outgrowth via interaction with the 5/33 integrin. Mol Biol Cell 9:277-290.
49. Zhang Y, Campbell G, Anderson PN, Lieberman AR, Martini R, Schachner M. 1995. The molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts. J Comp Neurol 361:193-209.
50. Zhao X, Siu C. 1995. Colocalization of the homophilic binding site and the neuritogenic activity of the cell adhesion molecule LI to its second Ig-like domain. J Biol Chem 270:29413-29421.
51. Zhao X, Yip PM, Siu C. 1998. Identification of a homophilic binding site in immunoglobulin-like domain 2 of the cell adhesion molecule LI. J Neurochem 71:960-971.