High-level rearrangement and transcription of yeast artificial chromosome-based mouse Igκ transgenes containing distal regions of the contig

Journal of Immunology

Volumn 164, Issue 2, 2000, Pages 812-824

  Li, Shuyu ^a   Hammer, Robert E ^b   George Raizen, Julia B ^a   Meyers, Katherine C ^a   Garrard, William T ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTIG;

ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; GENE LOCUS; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TRANSGENE; YEAST ARTIFICIAL CHROMOSOME;

EID: 0034650613     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.812     Document Type: Article

References (81)

1. George, J. B., S. Li, and W. T. Garrard. 1997. The murine immunoglobulin κ locus: new insights into genome organization and expression. In The Antibodies, Vol. 4, J. D. Capra and M. Zanelti, eds. Gordon and Breach/Harwood Academic Publisher, San Diego, p. 41.
2. Henderson, A., and K. Calame. 1998. Transcriptional regulation during B cell development. Annu. Rev. Immunol. 16:163.
3. Reya, T., and R. Grosschedi. 1998. Transcriptional regulation of B-cell differentiation. Curr. Opin. Immunol. 10:158.
4. Lewis, S. M., and G. E. Wu. 1997. The origins of V(D)J recombination. Cell 88:159.
5. Papavasiliou, F., M. Jankovic, S. Gong, and M. C. Nussenzweig. 1997. Control of immunoglobulin gene rearrangements in developing B cells. Curr. Opin. Immunol. 9:233.
6. Grawunder, U., R. B. West, and M. R. Lieber. 1998. Antigen receptor gene reaarangement. Curr. Opin. Immunol. 10:172.
7. Green, N. S., M. M. Lin, and M. D. Scharff. 1998. Somatic hypermutation of antibody genes: a hot spot warms up. BioEssays 20:227.
8. Neuberger, M. S., M. R. Ehrenstein, N. Klix, C. S. Jolly, J. Yelamos, C. Reda, and C. Milstein. 1998. Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunol. Rev. 162:107.
9. Storb, U., A. Peters, E. Klotz, N. Kim, H. M. Shen, J. Hackett, B. Rogerson, and T. E. Martin. 1998 Cis-acting sequences that affect somatic hypermutation of Ig genes. Immunol. Rev. 162:153.
10. Lichtenstein, M., G. Keini, H. Cedar, and Y. Bergman. 1994. B cell-specific demethylation: a novel role for the intronic κ chain enhancer sequence. Cell 76:913.
11. Hale, M. A., and W. T. Garrard. 1998. A targeted κ immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits spontaneous hyper-recombination in pre-B cells. Mol. Immunol. 35:609.
12. Mostoslavsky, R., N. Singh, A. Kirillov, R. Pelanda, H. Cedar, A. Chess, and Y. Bergman. 1998. Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12:1801.
13. Roque, M. A., P. A. Smith, and V. C. Blasquez. 1996. A developmentally modulated chromatin structure at the mouse immunoglobulin κ 3′ enhancer. Mol. Cell. Biol. 16:3138.
14. Stanhope-Baker, P., K. M. Hudson, A. L. Shaffer, A. Constanitinescu, and M. S. Schlissel. 1996. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85:887.
15. O'Brien, D. P., E. M. Oltz, and B. G. Van Ness. 1997. Coordinate transcription and V(D)J recombination of the κ immunoglobulin light chain locus: NF-κB-dependent and independent pathways of activation. Mol. Cell. Biol. 17:3477.
16. Shaffer, A. L., A. Peng, and M. S. Schlissel 1997. In vivo occupancy of the κ light chain enhancers in primary pro- and pre-B cells: a model for κ locus activation. Immunity 6:131.
17. Nagawa, F., K. Ishiguro, A. Tsuboi, T. Yoshida, A. Ishikawa, T. Takemori, A. J. Otsuka, and H. Sakano. 1998. Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination. Mol. Cell. Biol. 18:655.
18. George, J. B., S. Li, and W. T. Garrard. 1995. Yeast artificial chromosome contigs reveal that distal variable regions genes reside at least 3 megabases from the joining regions in the murine immunoglobulin κ locus. Proc. Natl. Acad. Sci. USA 92:12421.
19. Schupp, I. W., T. Schlake, T. Kirschbaum, H. G. Zachau, and T. Boehm. 1997. A yeast artificial chromosome contig spanning the mouse immunoglobulin κ light chain locus. Immunogenetics 45:180.
20. Kirschbaum, T. R., R. Jacnichen, and H. G. Zachau. 1996. The mouse immunoglobulin κ locus contains about 140 variable gene segments. Eur. J. Immunol. 26:1613.
21. Strohal, R., A. Helmberg, G. Kroemer, and R. Kofler. 1989. Mouse Vκ gene classification by nucleic acid sequence similarity, Immunogenetics 30:475.
22. D'Hoostelaere, L. A., and D. Klinman. 1990. Characterization of new mouse Vκ groups. J. Immunol. 145:2706.
23. Roschenthaler, F., T. Kirschbaum, V. Heim, V. Kirschbaum, K. F. Schable, J. Schwendinger, I. Zocher and H. G. Zachau. 1999. The 5′ part of the mouse immunoglobulin κ locus. Eur. J. Immunol. 29:2065.
24. Thiebe, R., K. F. Schable, A. Bench, J. Brensing-Kuppers, V. Heim, T. Kirschbaum, H. Mitlohner, M. Ohnrich, S. Pourrajabi, F. Roschenthaler, et al. 1999. The variable genes and gene families of the mouse immunoglohulin κ locus. Eur. J. Immunol. 29:2072.
25. Schable, K. F., R. Thiebe, A. Bench, J. Brensing-Kuppers, V. Heim, T. Kirschbaum, R. Lamm, M. Ohnrich, S. Pourrajabi, F. Roschenthaler, et al. 1999. Characterisitics of the immunoglobulin Vκ genes, pseudogenes. relics and orphons in the mouse genome. Eur. J. Immunol. 29:2082.
26. Kirschbaum, T., S. Pourrajabi, I. Zocher, J. Schwendinger, V. Heim, F. Roschenthaler, V. Kirschbaum, and H. G. Zachau. 1998. The 3′ part of the immunoglobulin κ locus of the mouse. Eur. J. Immunol. 28:1458.
27. Martin, D. J., and B. G. Van Ness. 1990. Initiation and processing of two κ immunoglobulin germ line in transcripts in mouse B cells. Mol. Cell. Biol. 10: 1950.
28. Ferradini, L., H. Gu, A. D. Smet, K. Rajewsky, C. A. Reynaud, and J. C. Weill. 1996. Rearrangement-enhancing element upstream of the mouse immunoglobulin κ chain J cluster. Science 271:1416.
29. Cockerill, P. N., and W. T. Garrard. 1986. Chromosomel loop anchorage of the κ immunglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites. Cell 44:273.
30. Queen, C., and D. Baltimore. 1983. Immunoglobulin gene transcription is activated by downstream sequence elements. Cell 33:741.
31. Meyer, K. B., and M. S. Neuberger. 1989. The immunoglobulin κ locus contains a second, stronger B-cell-specife enhancer which is located downstream of the constant region. EMBO J. 8:1959.
32. Cocea, L., A. De Smet, M. Saghatchian, S. Fillatreau, L. Ferradini, S. Schurmans, J.-C. Weil, and C.-A. Reynaud. 1999. A targeted deletion of a region upstream from the Jκ cluster impairs κ chain rearrangement in cis in mice and in the 103/bel2 cell line. J. Exp. Med. 189:1443.
33. Liu, X., and B. Van Ness. 1999. Gene targeting of the KI-KII sequence elements in a model pre-B cell line: effects on germline transcription and rearrangement of the κ locus. Mol. Immunol. 36: 461.
34. Yi, M., P. Wu, K. W. Trevorrow, L. Claffin, and W. T. Garrard. 1999. Evidence that the κ immunoglobulin gene MAR regulates the probability of premature V-J joining and somatic hypermutation. J. Immunol. 162:6029.
35. Xu, Y., L. Davidson, F. W. Alt, and D. Baltimore. 1996. Deletion of the Igκ light chair intronic enhancer/matix attachment region impairs but does not abolish Vκ-Jκ rearrangement. Immunity 4:377.
36. Gorman, J. R., N. van der Stoep, R. Monroe, M. Cogne, L. Davidson, and F. W. Alt. 1996. The Igκ 3′ enhancer influences the ratio of Igκ versus Igλ B lymphocytes, Immunity 5:241.
37. Green, L. L., M. C. Hardy, C. E. Maynard-Currie, H. Tsuda, D. M. Louie, M. J. Mendez, H. Abderrahim, M. Noguchi, D. H. Smith, Y. Zeng, et al. 1994. Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat. Genet. 7:13.
38. Lonberg, N., L. D. Taylor, F. A, Harding, M. Trounstine, K. M. Higgins, S. R. Schramm, C. C. Kuo, R. Mashayekh, K. Wymore, J. G. McCabe, et al. 1994. Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature 368:856.
39. Zou, X., J. Xian, N. P. Davies, A. V. Popov, and M. Bruggemann. 1996. Dominant expression of a 1.3 Mb human Igκ locus replacing mouse light chain production. FASEB J. 10:1227.
40. Cavelier, P., F. Nato, I. Coquilleau, A. Rolink, F. Rougeon, and M. Goodhardt. 1997. B lineage-restricted rearrangement of a human Ig κ trarsgene. Eur. J. Immmunol. 27:1626.
41. Xian, J., X. Zou, A. V. Popov, C. A. Mundt, N. Miller, G. T. Williams, S. L. Davies, M. S. Neuberger, and M. Bruggemann. 1998. Comparison of performance of a plasmid-based human Igκ minilocus and a YAC-based human Igκ transloci for the production of human antibody repertoires in transgenic mice. Transgenics 2:333.
42. Mendez, M. J., L. L. Green, J. R. F. Corvalan, X. C. Jia, C. E. Maynard-Currie, X. Yang, M. L. Gallo, D. M. Louie, D. V. Lee, K. L. Erickson, et al. 1997. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat. Genet. 15:146.
43. Tomizuka, K., H. Yoshida, H. Uejima, H. Kugoh, K. Sato, A. Ohguma, M. Hayasaka, K. Hanaoka, M. Oshimura, and I. Ishida. 1997. Functional expression and germline transmission of a human chromosome fragment in chimaeric mice. Nat. Genet. 16:133.
44. Huxley, C. 1994. Transfer of YACs to mammalian cells and transgenic mice. In Genetic Engineering. J. K. Setlow, ed. Plenum, New York, p. 65.
45. Peterson, K. R., C. H. Clegg, Q. Li, and G. Stamatoyannopoulos. 1997. Production of transgenic mice with yeast artificial chromosomes. Trends Genet. 13:61.
46. Reeves, R. H., W. J. Pavan, and P. Hieter. 1992. Yeast artificial chromosome modification and manipulation. Methods Enzymol. 216:584,
47. Barnes, D. A., and J. Thorner. 1986. Genetic manipulation of Sacchoromyces cerevisiae by use of the LYS2 gene. Mol. Cell. Biol. 6:2828.
48. Ito, H., Y. Fukuda. K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali conditions. J. Bacteriol. 53:163.
49. Apel, T. W., A. Scherer, T. Adachi, D. Auch, M. Ayane, and M. Reth. 1995. The ribose 5-phosphate isomerase-encoding gene is located immediately downstream from that encoding murine immunoglobulin κ. Gene 156:191.
50. Burgers, P. M. J,. and K. J. Percival 1987. Transformation of yeast spheroplasts without cell fusion. Anal. Biochem. 163:391.
51. Church, G. M., and W. Gilbert, 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991.
52. Langle-Roualt, F., and E. Jacob. 1995. A method for performing precise alterations in the yeast genome using a recyclable selectable marker. Nucleic Acids Res. 23:3079.
53. Schneider-Stock, R., and J. T. Epplen. 1995. Congenic AB mice: a novel means for studying the (molecular) genetics of aggression. Behav. Genet. 25:475.
54. Hamvas, R. M., and H. R. Lehrach. 1995. Repetitive sequence fingerprinting in the long range mapping of mammalian genomes. Electrophoresis 16:1602.
55. Guacci, V., and D. Kaback. 1991. Distributive disjunction of authentic chromosomes in Saccharomyces cerevisiae. Genetics 127:475.
56. Peterson, K. R., C. H. Clegg, C. Huxley, B. M. Josephson, H. S. Haugen, T. Furukawa, and G. Stamatoyannopoulos. 1993. Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human β-globin locus display proper developmental control of human globin genes. Proc. Natl. Acad. Sci. USA 90:7593.
57. Schlissel, M. S., and D. Baltimore. 1989. Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription. Cell 58:1001.
58. Kearney, J. F., A. Radbruch, B. Liesegang, and K. Rajewsky. 1979. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123:1548.
59. Brown, T. 1994. Northern hybridization of RNA fractionated by agarose-form-aldehyde gel electrophoresis. In Current Protocols in Molecular Biology. F.M. Ausubel, ed. John Wiley & Sons, New York, p. 492.
60. McKee-Johnson, J. W., and R. H. Reeves 1996. Fragmentation and integrative modification of YACs. In Methods in Molecular Biology, Vol. 54. D. Markie, ed. The Humana Press, Totowa, NJ, p. 167.
61. Li, S, 1999. The mouse immunglobulin κ light chain gene locus: genomic structure and gene regulation. Doctoral dissertation. University of Texas Southwestern Medical Center, Dallas, Texas.
62. Palmiter, R. D., and R. L. Brinster. 1986. Germ-line transformation of mice. Annu. Rev. Genet.20: 465.
63. Goodhardt, M., C. Babinet, G. Lutfalla, S. Kallenbach, P. Cavelier, and F. Rougeon. 1989. Immunoglobulin κ light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement. Nucleic Acids Res. 17: 7403.
64. Taylor, L. D., C. E. Carmack, S. R. Schramm, R. Mashayekh, K. M. Higgins, C.-C. Kuo, C. Woodhouse, R. M. Kay, and N. Lonberg. 1992. A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins. Nucleic Acids Res. 20:6287.
65. Komori, T., A. Okada, V. Stewart, and F. W. Alt. 1993. Lack of N regions in antigen receptor variable region genes of TdT-deflcient lymphocytes. Science 261:1171.
66. Hiramatsu, R., K. Akagi, M. Matsuoka, K. Sakumi, H. Nakamura, L. Kingsbury, C. dacid, R. R. Hardy, K.-I. Yamamura, and H. Sakano. 1995. The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining. Cell 83:1113.
67. Goodhardt, M., P. Cavelier, M. A. Akimenko, C. Babinet, and F. Rougeon. 1987. Rearrangement and expression of rabbit immunoglobulin κ light chain gene in transgenic mice. Proc. Natl. Acad. Sci. USA 84:4229.
68. Bucchini, D., C.-A. Reynuad, M.-A. Ripoche, H. Grimal, J. Jami, and J.-C. Weill. 1987. Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice. Nature 326:409.
69. Kofler, R., R. Strohal, R. S. Balderas, M. E. Johnson, D. J. Noonan, M. A. Duchosal, F. J. Dixon, and A. N. Theofilopoulos. 1988. Immunoglobulin κ light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice. J. Clin. Invest. 82:852.
70. Larionov, V., N. Kouprina, N. Nikolaishvili, and M. A. Resnick. 1994. Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs). Nucleic Acids Res. 22:4154.
71. Henikoff, S. 1998. Conspiracy of silence among repeated transgenes. BioEssays 20:532.
72. Kallenbach, S., C. Babinet, S. Pournin, P. Cavelier, M. Goodhardt, and F. Rougeon. 1993. The intronic immunoglobulin κ gene enhancer acts independently on rearrangement and on transcription. Eur. J. Immunol. 23:1917.
73. Geyer, P. K. 1997. The role of insulator elements in defining domains of gene expression. Curr. Opin. Genet. Dev. 7:242.
74. Bell, A. C., and G. Felsenfeld. 1999. Stopped at the border: boundaries and insulators. Curr. Opinion Genet. Dev. 9:191.
75. Schlissel, M. S., L. M. Corcoran, and D. Baltimore. 1991. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173:711.
76. Baker, J. E., D. Cado, and D. H. Raulet. 1998. Developmentally programmed rearrangement of T cell receptor Vγ genes is controlled by sequences immediately upstream of the Vγ genes. Immunity 9:159.
77. Fitzsimmons, S. P., B. T. Rotz, and M. A. Shapiro. 1998. Asymmetric contribution to Ig repertoire diversity by Vκ exons: differences in the utilization of Vκ10 exons. J. Immunol. 161:2290.
78. H gene segments is mediated by cis elements. J. Immunol. 161:3444.
79. Grosveld, F., G. Blom van Assendelfl, D. Greaves, and G. Kollias. 1987. Position independent expression of the human β globlin gene in transgenic mice. Cell 51:975.
80. Kamakaka, R. T. 1997. Silencers and locus control regions: opposite sides of the same coin. Trends Biochem. Sci. 22:124.
81. Li, S., J. B. George-Raizen, R. E. Hammer, and W. T. Garrard. 1998. Accurate quantification of expression of transgenes marked with restriction endonuclease site polymorphisms by RT-PCR. BioTechniques 25:558.