Using Haber's Law to define the margin of exposure

Toxicology

Volumn 149, Issue 1, 2000, Pages 1-2

  Doull, John ^a   Rozman, K K ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Haber's Law; Margin of exposure; MOE; New paradigm; Risk assessment

Indexed keywords

DOSE TIME EFFECT RELATION; ECOTOXICOLOGY; MATHEMATICAL COMPUTING; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK ASSESSMENT; SHORT SURVEY; TOXICOKINETICS;

EID: 0034648303     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00226-2     Document Type: Article

References (5)

1. Rozman, K.K., 1999. Delayed acute toxicity of 1,2,3,4,6,7,8 heptachloro dibenzo-p-dioxin after oral administration obeys Haber's rule of inhalation toxicology. Toxicol. Sci. 49, 102-109.
2. Rozman, K.K., Doull, J., 1998. General principles of toxicology. In: Rose, J. (Ed.), Environmental Toxicology: Current Developments. In: Environmental Topics, vol. 7. Environmental Toxicology, Current Developments, Gordon and Breach, Preston, UK Chap. 1.
3. Rozman, K.K., Doull, J., 1999. Hormesis, regulation, toxicity and risk assessment. BELLE Newslett. 8 (1), 2-6.
4. Rozman, K.K., Kerecsen, L., Viluksela, M.K., Osterle, D., Erhard, D., Viluksela, M., Bernhard, U.S., Greim, H., Doull, J.A., 1996. Toxicologists' view of cancer risk assessment. Drug Metab. Rev. 28 (1,2), 29-52.
5. Rozman, K.K., Doull, J., 2000. Dose and time as variables of toxicity. Toxicology 144, 169-178.