Distinct RNA structural domains cooperate to maintain a specific cleavage site in the 3'-UTR of IGF-II mRNAs

Journal of Molecular Biology

Volumn 300, Issue 3, 2000, Pages 449-467

  Van Dijk, E L ^a   Sussenbach, J S ^a   Holthuizen, P E ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

3' UTR; Endonucleolytic cleavage; Insulin like growth factor II; RNA folding; RNA secondary structure

Indexed keywords

ENDONUCLEASE; MESSENGER RNA; NUCLEOTIDE; POLYADENYLIC ACID; RIBONUCLEASE; SOMATOMEDIN B;

3' UNTRANSLATED REGION; ARTICLE; CODING; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; GENE DELETION; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA CLEAVAGE; RNA STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

EID: 0034647422     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3856     Document Type: Article

References (37)

1. Alpha helix-RNA major groove recognition in an HIV1 rev peptide-RRE RNA complex
2. Degradation of mRNA in eukaryotes
3. Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5'-AAU-3'/5'-UAA-3' elements in single-stranded loop domains of the 3'-non-coding region
4. Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening
5. U3 small nucleolar RNA is essential for cleavage at sites 1, 2, and 3 in pre-rRNA and determines which rRNA processing pathway is taken in Xenopus oocytes
6. A very strong enhancer is located upsteam of an immediate early gene of human cytomegalovirus
7. Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes
8. Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila
9. Cleavage properties of an estrogen-regulated polysomal ribonuclease involved in the destabilization of albumin mRNA
10. A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA
11. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations
12. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
13. Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein
14. Firefly luciferase gene: Structure and expression in mammalian cells
15. Purification and characterization of the estrogen-regulated Xenopus liver polysomal nuclease involved in the selective destabilization of albumin mRNA
16. Transcriptional regulation and biological significance of the insulin like growth factor II gene
17. A new technique for the assay of infectivity of human adenovirus 5 DNA
18. Differential expression of the human, rat and mouse IGF-II genes
19. Regulation of IGF gene expression
20. In vivo generation of 3' and 5' truncated species in the process of c-myc mRNA decay
21. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells
22. Transcriptional control signals of a eukaryotic protein-coding gene
23. Specific endonucleolytic cleavage of IGF-II mRNAs
24. Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene
25. Endonucleolysis in the turnover of insulin-like growth factor II mRNA
26. mRNA stability in mammalian cells
27. Substrate requirements for a novel archaeal endonuclease that cleaves within the 5' external transcribed spacer of Sulfolobus acidocaldarius precursor rRNA
28. Long-range RNA interaction of two sequence elements required for endonucleolytic cleavage of human insulin-like growth factor II mRNAs
29. Removal of a 3' non-coding sequence is an initial step in degradation of groα mRNA and is regulated by interleukin-1
30. C-myc RNA degradation in growing and differentiating cells: Possible alternate pathways
31. The sarcin/ricin loop, a modular RNA
32. Identification of RNA sequences and structures involved in site-specific cleavage of IGF-II mRNAs
33. Life and death in the cytoplasm: Messages from the 3' end
34. The conformation of loop E of eukaryotic 5S ribosomal RNA
35. On finding all suboptimal foldings of an RNA molecule